Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, the author is Doi, Ryohei and a compound is mentioned, 564483-18-7, 2-(Dicyclohexylphosphino)-2′,4′,6′-tri-i-propyl-1,1′-biphenyl, introducing its new discovery. 564483-18-7
Palladium-Catalyzed Decarboxylative Alkynylation of alpha-Acyloxyketones by C(sp3)?O Bond Cleavage
Palladium-catalyzed decarboxylative alkynylation of alpha-acyloxyketones triggered by C(sp3)?O bond cleavage is disclosed. The decarboxylation strategy featuring a neutral reaction condition enabled an unprecedent catalytic alkynylation of a ketone enolate. The reaction was applied to a variety of substrates, giving desired products in good yields. We successfully obtained X-ray crystallography of a new palladium?enolate intermediate that was synthesized by a reaction of [Pd(cod)(CH2TMS)2] with XPhos and alpha-acyloxyketone at room temperature, indicating facile C(sp3)?O bond disconnection.
But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! Read on for other articles about 564483-18-7!, 564483-18-7
Reference£º
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate