With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.855-38-9,Tris(4-methoxyphenyl)phosphine,as a common compound, the synthetic route is as follows.,855-38-9
To azide 6 [8a,14] (436?mg, 0.832?mmol) in Et2O (2.1?mL) under argon atmosphere was added tris(4-methoxyphenyl)phosphine (293?mg, 0.832?mmol) at rt. Stirring was maintained at rt for 24?h and then pentane (2.0?mL) was added and the resultant thick precipitate was filtered. The precipitate was washed with pentane/Et2O 1:1 (1?mL) and dried in vacuo to obtain the title compound 1d as a colourless solid (630?mg, 90%). MP 168-170?C; [alpha]D24?=?-18.0 (c?=?0.59, CHCl3); 1H NMR (500?MHz, CDCl3) delta ppm 2.99 (br. s, 1H), 3.10 (br. s, 1H), 3.82 (s, 9H), 3.97-4.09 (m, 1H), 5.11 (br. s, 1H), 6.88 (d, J?=?5.5?Hz, 6H), 7.11-7.21 (m, 6H), 7.22-7.31 (m, 7H), 7.31-7.45 (m, 6H), 7.63 (s, 2H); 13C NMR (125?MHz, CDCl3) delta ppm 50.3, 55.0, 55.6, 59.9, 115.0 (d, JPC?=?11.4?Hz), 123.8 (q, JFC?=?272.8?Hz), 126.6, 126.9 (br. s), 128.1, 128.5, 128.8, 128.9 (br. s), 130.6 (q, JFC?=?32.4?Hz), 134.9 (JPC?=?11.5?Hz), 142.9, 163.7; 31P NMR (162?MHz, CDCl3) delta ppm 27.6 (br s); 19F NMR (376?MHz, CDCl3) delta ppm – 62.6; IR numax/cm-1 3027, 2963, 1624, 1594, 1499, 1471, 1388, 1258, 1118, 1028, 804, 700; HRMS (ESI+): calcd. for C45H40F6N3O3PS [M+H]+ 848.2505, found 848.2492.
The synthetic route of 855-38-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Farley, Alistair J.M.; Jakubec, Pavol; Goldys, Anna M.; Dixon, Darren J.; Tetrahedron; vol. 74; 38; (2018); p. 5206 – 5212;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate