Day: November 23, 2020

564483-19-8, Di-tert-butyl(2′,4′,6′-triisopropyl-[1,1′-biphenyl]-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

564483-19-8, Example 571 91 mg of 2,4-dichlorophenol was added to 2.1 mL of toluene suspension containing 22 mg of 60% sodium hydride at room temperature, and the resulting mixture was heated to reflux under nitrogen atmosphere for 15 minutes. After the reaction mixture was cooled to room temperature, 70 mg of tert-butyl 2-(benzamido)-4-bromobenzoate, 4.7 mg of 2-(di-tert-butylphosphino)-2′,4′,6′-triisopropylbiphenyl and 6.8 mg of tris(dibenzylideneacetone)dipalladium(0) were added and the resulting mixture was heated to reflux under nitrogen atmosphere for 6 hours. After the reaction mixture was cooled to room temperature, 61 mg of 2,4-dichlorophenol, 15 mg of 60% sodium hydride, 4.7 mg of 2-(di-tert-butylphosphino)-2′,4′,6′-triisopropylbiphenyl and 6.8 mg of tris(dibenzylideneacetone)dipalladium(0) were added and the resulting mixture was heated to reflux under nitrogen atmosphere for 10 hours. After the reaction mixture was cooled to room temperature, 10% citric acid aqueous solution and ethyl acetate were added and insoluble were removed by filtration. The organic layer was separated and dried over anhydrous magnesium sulfate after washed with a saturated sodium chloride aqueous solution, and the solvent was evaporated under reduced pressure. The obtained residue was purified with silica gel column chromatography [PSQ100B (spherical) manufactured by Fuji Silysia Chemical Ltd., eluent; hexane: ethyl acetate = 20:1] to obtain tert-butyl 2-(benzamido)-4-(2,4-dichlorophenoxy)benzoate.

564483-19-8 Di-tert-butyl(2′,4′,6′-triisopropyl-[1,1′-biphenyl]-2-yl)phosphine 11618717, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; TOYAMA CHEMICAL CO., LTD.; EP1820795; (2007); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.787618-22-8,Dicyclohexyl(2′,6′-diisopropoxy-[1,1′-biphenyl]-2-yl)phosphine,as a common compound, the synthetic route is as follows.

General procedure: Representative procedure for the preparation of rPdtoptionally substituted (Ri?), allyl)(liqand)(X) complexes: A dry Schlenk tube is charged with the ligand (4.74 mmol) and [(optionally substituted (Ri2)m- allyl)PdCI]2 (2.36 mmol). The tube is evacuated and backfilled with nitrogen a total of three times. 10 mL of anhydrous solvent (such as THF or toluene) is added and the mixture is stirred at room temperature for a period of time (e.g . 20 minutes). Pentane (5 mL) or hexanes is added to fully precipitate the product. The product is collected by vacuum filtration, washed (3 x 10 mL of pentane, or hexanes) and dried under vacuum, 787618-22-8

787618-22-8 Dicyclohexyl(2′,6′-diisopropoxy-[1,1′-biphenyl]-2-yl)phosphine 121592071, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; JOHNSON MATTHEY PUBLIC LIMITED COMPANY; COLACOT, Thomas; CHOW, Ruishan; JON DEANGELIS, Andrew; WO2015/189554; (2015); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

12150-46-8, 1,1-Bis(diphenylphosphino)ferrocene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The heteroleptic nickel, palladium and platinum complexes (1?10) were prepared according to the general procedure shown in Scheme 1. To a stirring 15 ml methanolic solution of the ligand K2(p-CH3C6H4SO2N=CS2)¡¤2H2O (0.18 g, 0.5 mmol), K2(p-ClC6H4SO2N=CS2)¡¤2H2O (0.19 g, 0.5 mmol), K2(p-BrC6H4SO2N=CS2)¡¤2H2O (0.21 g, 0.5 mmol) or K2C2H5OCO(CN)CCS2 (0.13 g, 0.5 mmol) a 10ml aqueous solution of NiCl2¡¤6H2O (0.12 g, 0.5 mmol), K2PdCl4 (0.163 g, 0.5 mmol) or K2PtCl4 (0.21 g, 0.5 mmol) was added and in each case the reaction mixture was stirred for half an hour to get a clear solution. To this 25 ml solution was added a 10 ml dichloromethane solution of 1,1?-bis(diphenylphosphino)ferrocene (0.28 g, 0.5 mmol) with vigorous stirring and then further stirred for 12 h in the case of Ni and 24 h for Pd and Pt complexes. The volume of the reaction mixtures were reduced to 15 ml on rotary evaporator and the solid products thus obtained were filtered off and washed with H2O?CH3OH (40:60 v/v) and dried in vacuo over calcium chloride.

12150-46-8, 12150-46-8 1,1-Bis(diphenylphosphino)ferrocene 51341936, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Singh, Santosh K.; Chauhan, Ratna; Diwan, Kiran; Drew, Michael G.B.; Bahadur, Lal; Singh, Nanhai; Journal of Organometallic Chemistry; vol. 745-746; (2013); p. 190 – 200;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

855-38-9, Tris(4-methoxyphenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,855-38-9

1a (70.5 mg, 0.20 mmol), 4-phenylthioxanthone (3 mg, 0.01 mmol), CH3OH (30 mL) were added to a pyrex reaction flash which was equipped with a magnetic stirrer. The mixture was irradiated by a 23 W household lamp at rt under air atmosphere. The photoreaction was completed after 40 minutes as monitored by TLC (eluent: petroleum ether). The solvent was removed and the residue was purified by flash column chromatography on silica gel (eluent: petroleum ether/ethyl acetate = 10/1?EA) to afford 2a as a solid (74 mg, 100%); 1H NMR (400 MHz, CDCl3) delta 7.56 (dd, J = 11.6, 8.8 Hz, 6 H), 6.95 (dd, J = 8.8, 2.0 Hz, 6 H), 3.83 (s, 9 H).

The synthetic route of 855-38-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ding, Aishun; Li, Shijie; Chen, Yang; Jin, Ruiwen; Ye, Cong; Hu, Jianhua; Guo, Hao; Tetrahedron Letters; vol. 59; 43; (2018); p. 3880 – 3883;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.607-01-2,Ethyldiphenylphosphine,as a common compound, the synthetic route is as follows.

General procedure: The phosphine ligand (PPh2R and PPhR2; R=Me or Et) (0.5mmol) was directly added to the solution of the starting complex [PtCl(sac)(COD)] (COD=1,5-cyclooctadiene) (0.25mmol, 0.13g) in the mixture of MeCN and MeOH (1:1, 10mL). The reaction mixture was refluxed for 24h. Then, the solvents were removed by a rotary evaporator and the white solids were washed with diethyl ether and a small amount of cold EtOH. The solids were dissolved in a mixture containing water, MeCN and MeOH (1:1:1). The crystals of 2, 3 and 4 were obtained from the evaporation of the solutions after three or four weeks at r.t., 607-01-2

Big data shows that 607-01-2 is playing an increasingly important role.

Reference£º
Article; Icsel, Ceyda; Yilmaz, Veysel T.; Cevatemre, Buse; Aygun, Muhittin; Ulukaya, Engin; Journal of Inorganic Biochemistry; vol. 195; (2019); p. 39 – 50;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

787618-22-8,787618-22-8, Dicyclohexyl(2′,6′-diisopropoxy-[1,1′-biphenyl]-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 0846 A mixture of 7-bromo-N-(5-isopropylpyridazin-3-yl)-1,5-naphthyridine-2-amine (15 mg), pyrrolidine (11 muL), tris(dibenzylideneacetone)dipalladium(0) (4 mg), 2-dicyclohexylphosphino-2′,6′-diisopropoxybiphenyl (4 mg), sodium tert-butoxide (13 mg), and tert-amyl alcohol (0.5 mL) was stirred at 130 C. for 30 minutes using a microwave reaction apparatus. The reaction mixture was cooled to room temperature, the insolubles were filtered off, and the solvent was distilled off under reduced pressure. The obtained residue was purified by silica gel column chromatography (methanol-ethyl acetate), thereby obtaining N-(5-isopropylpyridazin-3-yl)-7-(pyrrolidin-1-yl)-1,5-naphthyridine-2-amine (12 mg) as a yellow solid. 1H-NMR (CDCl3) delta: 8.79-8.75 (2H, m), 8.68 (1H, s), 8.37 (1H, d, J=2.6 Hz), 8.10 (1H, d, J=8.6 Hz), 7.22 (1H, d, J=8.6 Hz), 6.96 (1H, d, J=2.6 Hz), 3.52-3.45 (4H, m), 3.06-2.97 (1H, m), 2.14-2.09 (4H, m), 1.39 (6H, d, J=7.3 Hz). MS m/z (M+H): 335.

As the paragraph descriping shows that 787618-22-8 is playing an increasingly important role.

Reference£º
Patent; FUJIFILM Corporation; FURUYAMA, Hidetomo; KURIHARA, Hideki; TERAO, Takahiro; NAKAGAWA, Daisuke; TANABE, Shintaro; KATO, Takayuki; YAMAMOTO, Masahiko; SEKINE, Shinichiro; MASHIKO, Tomoyuki; INUKI, Shinsuke; UEDA, Satoshi; US2015/322063; (2015); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.855-38-9,Tris(4-methoxyphenyl)phosphine,as a common compound, the synthetic route is as follows.,855-38-9

To azide 6 [8a,14] (436?mg, 0.832?mmol) in Et2O (2.1?mL) under argon atmosphere was added tris(4-methoxyphenyl)phosphine (293?mg, 0.832?mmol) at rt. Stirring was maintained at rt for 24?h and then pentane (2.0?mL) was added and the resultant thick precipitate was filtered. The precipitate was washed with pentane/Et2O 1:1 (1?mL) and dried in vacuo to obtain the title compound 1d as a colourless solid (630?mg, 90%). MP 168-170?C; [alpha]D24?=?-18.0 (c?=?0.59, CHCl3); 1H NMR (500?MHz, CDCl3) delta ppm 2.99 (br. s, 1H), 3.10 (br. s, 1H), 3.82 (s, 9H), 3.97-4.09 (m, 1H), 5.11 (br. s, 1H), 6.88 (d, J?=?5.5?Hz, 6H), 7.11-7.21 (m, 6H), 7.22-7.31 (m, 7H), 7.31-7.45 (m, 6H), 7.63 (s, 2H); 13C NMR (125?MHz, CDCl3) delta ppm 50.3, 55.0, 55.6, 59.9, 115.0 (d, JPC?=?11.4?Hz), 123.8 (q, JFC?=?272.8?Hz), 126.6, 126.9 (br. s), 128.1, 128.5, 128.8, 128.9 (br. s), 130.6 (q, JFC?=?32.4?Hz), 134.9 (JPC?=?11.5?Hz), 142.9, 163.7; 31P NMR (162?MHz, CDCl3) delta ppm 27.6 (br s); 19F NMR (376?MHz, CDCl3) delta ppm – 62.6; IR numax/cm-1 3027, 2963, 1624, 1594, 1499, 1471, 1388, 1258, 1118, 1028, 804, 700; HRMS (ESI+): calcd. for C45H40F6N3O3PS [M+H]+ 848.2505, found 848.2492.

The synthetic route of 855-38-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Farley, Alistair J.M.; Jakubec, Pavol; Goldys, Anna M.; Dixon, Darren J.; Tetrahedron; vol. 74; 38; (2018); p. 5206 – 5212;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13440-07-8,Di(naphthalen-1-yl)phosphine oxide,as a common compound, the synthetic route is as follows.

151 mg (0.5 mmol) of bis(1-naphthyl)phosphorus,115.5 mg (0.75 mmol) of 4,4-dimethoxy-2,5-cyclohexadien-1-one,0.05 mmol of water and 1.0 mL of toluene were placed in a Schlenk tube under nitrogen, and the reaction was stirred at 100 C for 12 hours. After completion of the reaction, it was purified by column chromatography, and the isolated yield was 64%., 13440-07-8

As the paragraph descriping shows that 13440-07-8 is playing an increasingly important role.

Reference£º
Patent; Hunan Institute of Science and Technology; Xiong Biquan; Wang Gang; Tang Kewen; Xu Weifeng; (8 pag.)CN109096331; (2018); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.829-85-6,Diphenylphosphine,as a common compound, the synthetic route is as follows.

829-85-6, General procedure: MCM-41-3N-Pd(0) (21mg, 0.01mmol), KOAc (1.5mmol) and aryl iodide 1 (1.0mmol) (if solid) were placed in an oven-dried 20mL Schlenk tube, the reaction vessel was evacuated and filled with argon for three times. Then aryl iodide 1 (1.0mmol) (if liquid), diphenylphosphine (1.2mmol) and DMAc (1mL) were added with a syringe under a counter flow of argon. The reaction mixture was stirred at 130C for 3h. After completion of the reaction, the mixture was cooled to room temperature and diluted with CH2Cl2 (20mL) and filtered. The MCM-41-3N-Pd(0) catalyst was washed with distilled water (2¡Á5mL) and ethanol (2¡Á5mL), and reused in the next run. The filtrate was concentrated in vacuo and the residue was purified by flash column chromatography on silica gel to provide the product 2.

As the paragraph descriping shows that 829-85-6 is playing an increasingly important role.

Reference£º
Short Survey; Xu, Zhaotao; Wang, Pingping; Chen, Qiurong; Cai, Mingzhong; Journal of Organometallic Chemistry; vol. 866; (2018); p. 50 – 58;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

63995-70-0, Sodium 3,3′,3”-phosphinetriyltribenzenesulfonate is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,63995-70-0

Under argon protection,(CH3 (EO) 16N + H = C (N (CH3) 2) 2] [CH3SO3-] and 10 mL of acetonitrile were added to a 50 mLSchlenk flask (SO3Na+)3-R6,4 ¡¤ 73 mmol The reaction mixture was stirred at room temperature for 72 hours. The filtrate was filtered under reduced pressure to give acetonitrile as an orange-yellow viscous liquid in 95% yield.

As the paragraph descriping shows that 63995-70-0 is playing an increasingly important role.

Reference£º
Patent; Qingdao University of Science and Technology; JIN, XIN; LI, SHU MEI; ZHAO, KUN; (11 pag.)CN103483381; (2016); B;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate