Day: November 20, 2020

63995-70-0, Sodium 3,3′,3”-phosphinetriyltribenzenesulfonate is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,63995-70-0

Under argon protection,(CH3 (EO) 16N + H = C (N (CH3) 2) 2] [CH3SO3-] and 10 mL of acetonitrile were added to a 50 mLSchlenk flask (SO3Na+)3-R6,4 ¡¤ 73 mmol The reaction mixture was stirred at room temperature for 72 hours. The filtrate was filtered under reduced pressure to give acetonitrile as an orange-yellow viscous liquid in 95% yield.

As the paragraph descriping shows that 63995-70-0 is playing an increasingly important role.

Reference£º
Patent; Qingdao University of Science and Technology; JIN, XIN; LI, SHU MEI; ZHAO, KUN; (11 pag.)CN103483381; (2016); B;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.166330-10-5,(Oxybis(2,1-phenylene))bis(diphenylphosphine),as a common compound, the synthetic route is as follows.

General procedure: NHC-Cu(I) complexes 1-3 were synthesized by the following route:a solution of imidazolium salt (0.4 mmol), copper powder (0.032 g,0.5 mmol) and POP (0.22 g, 0.4 mmol) reacted in CH3CN (5 mL) at60 C for 24 h. The resulting mixture was filtered through a plug ofCelite and concentrated to ca. 1 mL. Addition of Et2O (10 ml) to thefiltrate afforded a pale yellow precipitate, which was collected andwashed with Et2O. And the productwas recrystallized with ethanol., 166330-10-5

As the paragraph descriping shows that 166330-10-5 is playing an increasingly important role.

Reference£º
Article; Wang, Jinglan; Liu, Shaobo; Xu, Shengxian; Zhao, Feng; Xia, Hongying; Wang, Yibo; Journal of Organometallic Chemistry; vol. 846; (2017); p. 351 – 359;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17261-28-8,2-(Diphenylphosphino)benzoic acid,as a common compound, the synthetic route is as follows.

To a solution of 2-diphenylphosphinobenzoic acid (67 mg, 0.22 mmol) in dry CH2Cl2 (5 mL) under an argon atmosphere N-[3-(dimethylamino)propyl]-N-ethylcarbodiimide (50 mg, 0.26 mmol), hydroxybenzotriazole (36 mg, 0.26 mmol), and (1R,5S)-(-)-cytisine (50 mg, 0.26 mmol) were added at room temperature. The mixture was stirred at room temperature for 24 h and then was directly subjected to flash column chromatography (silica gel, CH2Cl2/CH3OH = 50:1) to give 104 mg (99percent yield) of 3 as a white solid; m.p. 126-128 ¡ãC. [alpha]D20 = -198.4 (c 0.64, CHCl3). 1H NMR (600 MHz, CDCl3, 253 K): 1:0.9 mixture of rotamers; signals for B-chair conformer: delta = 7.40-7.38 (m, 2H, Har), 7.37-7.34 (m, 1H, 10-H), 7.35-7.33 (m, 2H, Har), 7.32-7.30 (m, 3H, Har), 7.24-7.21 (m, 1H, Har), 7.20-7.16 (m, 3H, Har), 7.10 (dt, JH,H = 7.5, 0.6 Hz, 1H, Har), 7.06-7.02 (m, 1H, Har), 6.61 (dd, JH,H = 9.1, 1.2 Hz, 1H, 9-H), 6.15 (ddd, JH,H = 7.6, 3.6, 0.7 Hz, 1H, Har), 5.88 (dd, JH,H = 6.8, 1.0 Hz, 1H, 11-H), 4.85 (d, JH,H = 12.4 Hz, 1H, 4-Heq), 4.26 (d, JH,H = 15.6 Hz, 1H, 6-H), 3.90 (dd, JH,H = 15.6, 6.4 Hz, 1H, 6-H), 3.32 (d, JH,H = 12.7 Hz, 1H, 2-Heq), 2.94 (d, JH,H = 12.4 Hz, 1H, 4-Hax), 2.87 (brs, 1H, 1-H), 2.76 (dd, JH,H = 12.7, 1.6 Hz, 1H, 2-Hax), 2.61 (brs, 1H, 5-H), 2.05-1.92 (m, 2H, 13-H) ppm; resolved signals for A-chair conformer: delta = 7.45-7.42 (m, 1H, Har), 7.06-7.02 (m, 1H, Har), 7.37-7.34 (m, 1H, 10-H), 6.94 (ddd, JH,H = 7.5, 3.3, 0.6 Hz, 1H, Har), 6.54 (dd, JH,H = 9.0, 1.1 Hz, 1H, 9-H), 6.19 (dd, JH,H = 6.8, 0.7 Hz, 1H, 11-H), 4.75 (d, JH,H = 12.8 Hz, 1H, 2-Heq), 4.11 (d, JH,H = 15.6 Hz, 1H, 6-H), 3.74 (dd, JH,H = 15.6, 6.0 Hz, 1H, 6-H), 3.50 (d, JH,H = 12.6 Hz, 1H, 4-Heq), 3.20 (brs, 1H, 1-H), 3.04 (dd, JH,H = 12.8, 1.9 Hz, 1H, 2-Hax), 2.98 (d, JH,H = 12.6 Hz, 1H, 4-Hax), 2.32 (brs, 1H, 5-H), 2.05-1.92 (m, 2H, 13-H) ppm. 13C NMR (150.9 MHz, CDCl3, 253 K): signals for B-chair conformer: delta = 170.15 (Cq, C=O, amide), 163.19 (Cq, C=O, lactam), 148.16 (CH, 12-C), 141.27 (d, J31P,13C = 33.7 Hz, Cq, Car), 138.61 (CH, 10-C), 135.82 (d, J31P,13C = 9.9 Hz, Cq, Car), 135.70 (d, J31P,13C = 9.4 Hz, Cq, Car), 134.26 (d, J31P,13C = 20.7 Hz, 2 CH, Car), 134.00 (CH, Car), 133.63 (Cq, CCO), 133.06 (d, J31P,13C = 18.8 Hz, 2 CH, Car), 129.96 (CH, Car), 129.09 (CH, Car),129.03 (CH, Car), 128.56 (d, J31P,13C = 6.8 Hz, 2 CH, Car), 128.53 (d, J31P,13C = 7.8 Hz, 2 CH, Car), 128.29 (CH, Car), 126.06 (d, J31P,13C = 7.5 Hz, 1 CH, Car), 117.66 (CH, 9-C), 105.61 (CH, 11-C), 53.13 (d, J31P,13C = 1.8 Hz, CH2, 2-C), 49.01 (CH2, 6-C), 47.22 (CH2, 4-C), 34.37 (CH, 1-C), 26.93 (CH, 5-C), 25.72 (CH2, 13-C) ppm; signals for A-chair conformer: delta = 170.21 (Cq, C=O, amide), 163.26 (Cq, C=O, lactam), 148.18 (CH, 12-C), 141.65 (d, J31P,13C = 33.9 Hz, Cq, Car), 139.50 (CH, 10-C), 135.52 (d, J31P,13C = 8.5 Hz, Cq, Car), 135.42 (d, J31P,13C = 8.9 Hz, Cq, Car), 134.04 (d, J31P,13C = 20.3 Hz, 2 CH, Car), 134.04 (CH, Car), 133.76 (Cq, CCO), 133.03 (d, J31P,13C = 18.8 Hz, 2 CH, Car), 129.96 (CH, Car), 128.87 (CH, Car), 128.55 (CH, Car), 128.49 (CH, Car), 128.31 (d, J31P,13C = 6.5 Hz, 2 CH, Car), 128.27 (d, J31P,13C = 6.3 Hz, 2 CH, Car), 126.23 (d, J31P,13C = 7.9 Hz, 1 CH, Car), 117.19 (CH, 9-C), 106.42 (CH, 11-C), 52.23 (d, J31P,13C = 2.2 Hz, CH2, 4-C), 48.47 (CH2, 6-C), 48.30 (CH2, 2-C), 34.17 (CH, 1-C), 27.26 (CH, 5-C), 25.86 (CH2, 13-C) ppm. 31P{1H} NMR (242.92 MHz, CDCl3, 253 K): signal for B-chair conformer: delta = -14.07 ppm; signal for A-chair conformer: delta = -13.75 ppm. IR (KBr): nu = 3050, 2925, 2854, 1657, 1639, 1580, 1546, 1434, 1424, 1306, 1243, 745, 673 cm-1. MS (ESI): m/z = 479 (100, [M + 1]+), 289 (63). C30H27N2O2P (478.52): calcd. C 75.30, H 5.69, N 5.85, found C 75.63, H 5.81, N 5.96., 17261-28-8

17261-28-8 2-(Diphenylphosphino)benzoic acid 87021, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Philipova, Irena; Stavrakov, Georgi; Vassilev, Nikolay; Nikolova, Rositsa; Shivachev, Boris; Dimitrov, Vladimir; Journal of Organometallic Chemistry; vol. 778; (2015); p. 10 – 20;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

18437-78-0, Tris(4-fluorophenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 4.3.31 methyl 2-phenyl-5-(4-fluorophenyl)oxazole-4-carboxylate (4k) A suspension of Pd(OAc)2 (10 mol percent), Ar3P (0.33 mmol or 0.75 mmol), AgOAc (3.0 mmol), TFA (1.0 mmol) and azole-4-carboxylates (0.5 mmol) in NMP (2 mL) was introduced to a Schlenk tube. After stirring at 120 C under argon for 24 h (reactions with 0.33 mmol of Ph3P), or 48 h (reactions with 0.75 mmol of Ph3P), the reaction mixture was diluted with ethyl acetate, and then filtered through a pad of Celite. Volatiles were removed in vacuo to give the crude products, which was purified by flash column chromatography on silica gel to afford pure arylated products Yield 89 mg (60percent). White solid, mp 140-142 ¡ãC; 1H NMR (300 MHz, CDCl3) delta 3.95 (s, 3H), 7.16 (t, J=8.7 Hz, 2H), 7.44-7.47 (m, 3H), 7.09-7.18 (m, 4H) ppm; 13C NMR (75 MHz, CDCl3) delta 164.4, 161.6, 161.0, 158.6, 153.3, 130.1, 129.6, 129.5, 127.8, 126.6, 125.7, 125.1, 122.2, 122.1, 114.7, 114.4, 51.3 ppm; IR (KBr) 2950, 2844, 1715, 1505, 1434, 1355, 1235, 1094, 1009, 844, 708 cm-1; HRMS (ESI) calcd for [C17H12FNO3+H]+ 298.0874, found 298.0876.

18437-78-0, As the paragraph descriping shows that 18437-78-0 is playing an increasingly important role.

Reference£º
Article; Li, Ziyuan; Zhou, Haipin; Xu, Jinyi; Wu, Xiaoming; Yao, Hequan; Tetrahedron; vol. 69; 15; (2013); p. 3281 – 3286;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6372-42-5,Cyclohexyldiphenylphosphine,as a common compound, the synthetic route is as follows.,6372-42-5

Potassium tetrachloropalladate(II) was prepared by the procedure described in [26]. Potassium chloride, 2 equiv, was added to a solution of palladium(II) chloride in 25 mL of distilled water with stirring over a period of 30 min. The mixture was cooled with ice, and yellowish-brown crystals of potassium tetrachloropalladate(II) separated in a few minutes. The crystals were collected by filtration and recrystallized from water containing a few drops of aqueous HCl. The complexes were prepared by adding 2 equiv of the corresponding phosphine in 15 mL of acetonitrile to a solution of 0.326 g of K2[PdCl4] in15 mL of water, followed by stirring. After 30 min, a solution of 2 equiv of N,N-dimethylthiourea in 15 mL of methanol was added, and the mixture was stirred for one hour. The resulting yellow or red solution was filtered, and the filtrate was kept at room temperature for three to five days. Slow evaporation of the acetonitrile-methanol solution afforded solid complex 1-3. The overall reaction is shown in Scheme 1.

6372-42-5 Cyclohexyldiphenylphosphine 80756, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Aziz; Sirajuddin; Munir; Tirmizi; Nadeem; Tahir; Sajjad; Russian Journal of General Chemistry; vol. 88; 3; (2018); p. 551 – 559;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.564483-18-7,2-(Dicyclohexylphosphino)-2′,4′,6′-tri-i-propyl-1,1′-biphenyl,as a common compound, the synthetic route is as follows.

564483-18-7, Example 44A N-(2-Chloro-4-nitrophenyl)-1H-pyrrolo[2,3-b]pyridine-4-amine Variant A: A solution of 200 mg (1.31 mmol) of 4-chloro-1H-pyrrolo[2,3-b]pyridine, 271 mg (1.57 mmol) of 2-chloro-4-nitroaniline, 60 mg (0.07 mmol) of tris(dibenzylideneacetone)dipalladium, 62 mg (0.13 mmol) of dicyclohexyl(2′,4′,6′-triisopropylbiphenyl-2-yl)phosphine and 399 mg (2.88 mmol) of potassium carbonate in 2.00 ml of degassed tert-butanol is stirred in a sealed pressure vessel at 100 C. for 3 h. The mixture is then cooled to RT, and a further 136 mg (0.79 mmol) of 2-chloro-4-nitroaniline, 31 mg (0.07 mmol) of dicyclohexyl(2′,4′,6′-triisopropylbiphenyl-2-yl)phosphine and 30 mg (0.04 mmol of tris(dibenzylideneacetone)dipalladium are added and the mixture is stirred at 100 C. for a further 3 h. Variant B: A mixture of 200 mg (1.31 mmol) of 4-chloro-1H-pyrrolo[2,3-b]pyridine, 678 mg (3.93 mmol) of 2-chloro-4-nitroaniline, 60 mg (0.07 mmol) of tris(dibenzylideneacetone)dipalladium, 62 mg (0.13 mmol) of dicyclohexyl(2′,4′,6′-triisopropylbiphenyl-2-yl)phosphine and 399 mg (2.88 mmol) of potassium carbonate and 2.50 ml of degassed tert-butanol is stirred in a sealed pressure vessel at 100 C. for 3 h. After cooling to RT, the reaction mixtures of both synthesis variants are filtered through Celite, the Celite is washed with ethyl acetate and the filtrates are concentrated under reduced pressure. The residue is subjected to column chromatography on silica gel (mobile phase cyclohexane/ethyl acetate 10:1 to 100% ethyl acetate). This gives 145 mg of the partially purified product (purity 67%), 30 mg of which are purified by preparative HPLC. LC-MS (Method 1): Rt=1.28 min. MS (ESI pos.): m/z=289 (M+H)+. 1H-NMR (DMSO-d6, 300 MHz): delta=6.14-6.23 (m, 1H), 6.90 (d, 1H), 7.15 (d, 1H), 7.31-7.40 (m, 1H), 8.08 (dd, 1H), 8.12 (d, 1H), 8.34 (d, 1H), 9.01 (s, 1H), 11.68 (s, 1H).

564483-18-7 2-(Dicyclohexylphosphino)-2′,4′,6′-tri-i-propyl-1,1′-biphenyl 11155794, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Bayer HealthCare AG; US2008/269268; (2008); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6224-63-1, Tri-m-tolylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Phosphine 1 (0.21 g, 0.69 mmol) was dissolved in Et2O (5 ml)and elemental sulfur or selenium (0.70 mmol) was added andresulted mixture stirred during 1 h at room temperature. Then themixture was filtered off and Et2O was removed to give the phosphinechalcogenide 3 and 4 as powders., 6224-63-1

6224-63-1 Tri-m-tolylphosphine 80362, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Sterkhova; Smirnov; Malysheva; Kuimov; Belogorlova; Journal of Molecular Structure; vol. 1197; (2019); p. 681 – 690;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13991-08-7, 1,2-Bis(diphenylphosphino)benzene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

An oven dried 200 mL two-necked flask equipped with a magnetic stirring bar and a reflux condenser was charged with a solution of anhydrous lion (II) bromide (1.5 g, 6.95 mmol) and 1,2-bis (diphenylphosphino) benzene (3.41 g, 7.65 mmol) in ethanol (70 mL). The reaction flask was heated to 80 C for 18 hours, at this time pale brown colored precipitate was formed. The reaction mixture was cooled to room temperature. Filtered the brown solid and was washed with 100 mL of hot ethanol. The resulting yellowish brown solid 5a (3.54 g, 77%) was dried under high vacuum for 12 hours.

13991-08-7, As the paragraph descriping shows that 13991-08-7 is playing an increasingly important role.

Reference£º
Patent; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; KISHI, Yoshito; YAHATA, Kenzo; KUMAR, Vemula, Praveen; VADDELA, Sudheer, Babu; (137 pag.)WO2019/9956; (2019); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

12150-46-8, 1,1-Bis(diphenylphosphino)ferrocene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The reactions were run in a CEM Corp. MARS microwave fitted with a fiber optic temperature probe and a port on top for a reflux condenser.1 mmol of Mo(CO)6 and dppe (0.425 g, 1.1 mmol) were combined with 20 mL of 1-propanol in a two-neck 100 mL RB flask. To this mixture was added NaBH4 (0.128 g, 3.3 mmol). The flaskwas placed in themicrowave and a reflux condenser attached through a hole in the top of the microwave. The mixture was sparged with nitrogen. The mixture was heated under nitrogen at 400 W for 1.5 min to reach reflux temperature. Once the reflux temperature was reached the microwave power was reduced and the temperature maintained for 18 min. The mixture was cooled to room temperature and 2?4 mL of water was added to the reaction to dissolve excess NaBH4 and promote product precipitation. The reaction was cooled ?10 ¡ãC for several hours. The light yellow complex was filtered in air and washed with 2¡Á5 mL of petroleum ether/diethyl ether(1:1) mixture resulting in 580 mg of Mo(CO)4dppe after drying, a 95percent yield.

12150-46-8, 12150-46-8 1,1-Bis(diphenylphosphino)ferrocene 51341936, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Birdwhistell, Kurt R.; Schulz, Brian E.; Dizon, Paula M.; Inorganic Chemistry Communications; vol. 26; (2012); p. 69 – 71;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6372-42-5,Cyclohexyldiphenylphosphine,as a common compound, the synthetic route is as follows.,6372-42-5

General procedure: 1a (70.5 mg, 0.20 mmol), 4-phenylthioxanthone (3 mg, 0.01 mmol), CH3OH (30 mL) were added to a pyrex reaction flash which was equipped with a magnetic stirrer. The mixture was irradiated by a 23 W household lamp at rt under air atmosphere. The photoreaction was completed after 40 minutes as monitored by TLC (eluent: petroleum ether). The solvent was removed and the residue was purified by flash column chromatography on silica gel (eluent: petroleum ether/ethyl acetate = 10/1?EA) to afford 2a as a solid (74 mg, 100%); 1H NMR (400 MHz, CDCl3) delta 7.56 (dd, J = 11.6, 8.8 Hz, 6 H), 6.95 (dd, J = 8.8, 2.0 Hz, 6 H), 3.83 (s, 9 H).

As the paragraph descriping shows that 6372-42-5 is playing an increasingly important role.

Reference£º
Article; Ding, Aishun; Li, Shijie; Chen, Yang; Jin, Ruiwen; Ye, Cong; Hu, Jianhua; Guo, Hao; Tetrahedron Letters; vol. 59; 43; (2018); p. 3880 – 3883;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate