Day: November 19, 2020

12150-46-8, 1,1-Bis(diphenylphosphino)ferrocene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solutionof [C7H7][BF4] (64.6 mg, 0.363 mmol), in CHCl3(13 mL) dppf (100.1 mg, 0.181 mmol), was added and the solution was stirred atreflux for 7 hours. The solution was cooled and then stirred at roomtemperature for 13 hours. An orange solid precipitated and was collected byfiltration and dried under vacuum. Yield: 129.8 mg (79 percent).Anal. Calcd. For C48H42B2F8FeP2:C, 63.34; H, 4.65; N, 0.00. Found: C, 63.72; H, 4.95; N, 1H NMR (400 MHz, CDCl3,ppm): d 7.85 ? 7.65 (m, 20H, Ph), 6.37 (m, 4H, H4), 6.22 (m, 4H, H3), 5.07 (m, 4H, H2),4.84 (m, 4H, H5), 4.42 (m, 4H, H6), 4.18 (m, 2H, H1),.19F NMR (376.2 MHz, CDCl3,25 ¡ãC): delta -151.9 (s, F1). 31P{1H}-NMR(CDCl3, 25 C): 23.8 (s, P1).

12150-46-8, The synthetic route of 12150-46-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Kruse, Samantha M.; Hurst, Stephanie K.; Tetrahedron Letters; vol. 56; 46; (2015); p. 6319 – 6322;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

564483-19-8, Di-tert-butyl(2′,4′,6′-triisopropyl-[1,1′-biphenyl]-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: [(allyl)PdCl]2 (183 mg, 0.50 mmol); 22 AgOTf (257 mg, 1.00 mmol); 27 tBuXPhos (425 mg, 1.00 mmol); 24 THF (10.0 mL); 2 h. Product obtained as a slightly yellow solid (708 mg, 98%); 1H NMR (400 MHz, CDCl3, delta): 7.92 (t, J=7.3 Hz, 1H), 7.59-7.47 (m, 3H), 7.42-7.40 (m, 1H), 6.79 (dd, J=3.2 Hz, 7.5 Hz, 1H), 5.72 (sept, J=7.2 Hz, 1H), 4.49 (d, J=6.7 Hz, 1H), 3.52 (dd, J=9.0 Hz, 14.0 Hz, 1H), 3.03 (quint, J=7.1 Hz, 1H), 2.93 (d, J=12.9 Hz, 1H), 2.67-2.62 (m, 1H), 2.50 (quint, J=7.1 Hz, 1H), 2.26 (quint, J=6.9 Hz, 1H), 1.49-1.40 (m, 9H), 1.40-1.28 (m, 21H), 0.96 (d, J=6.7 Hz, 3H), 0.88 (d, J=6.7 Hz, 3H); 13C NMR (100 MHz, CDCl3, delta): 153.6, 152.7, 149.2, 146.0, 145.8, 135.1 (2 peaks), 134.9, 133.7, 133.6, 131.7, 131.6, 128.3, 128.2, 126.6, 126.2, 125.8, 122.6, 120.3 (2 peaks), 120.1 (2 peaks), 119.4, 116.2, 101.3, 101.1, 55.5, 38.3 (2 peaks), 38.2, 38.1, 33.9, 32.0, 31.7, 31.2, 31.1, 30.9, 30.8, 25.9, 25.4, 24.9, 24.5 (2 peaks), 24.1 [Observed complexity due to C-F and C-P coupling]; 19F NMR (372 MHz, CDCl3, delta): -78.1 (s, 3F); 31P NMR (162 MHz, CDCl3, delta): 70.1; Anal. calcd. for C33H50O3F3PSPd: C, 54.96; H, 6.99. Found C, 54.84; H, 7.13., 564483-19-8

The synthetic route of 564483-19-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Johnson Matthey Public Limited Company; Colacot, Thomas; Jon Deangelis, Andrew; (66 pag.)US9777030; (2017); B2;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6163-58-2, Tri-o-tolylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6163-58-2, N-(5-Vinyl-pyridin-2-yl)-acetamide . A solution of of N-(5-bromo-pyridin-2-yl)-acetamide (prepared as described in Preparation One, 4.30 g, 20 mmol) in acetonitrile (15 ml) and triethylamine (5.04 ml) was treated with palladium acetate (45 mg, 0.2 mmol) and tri-o-tolylphosphine (203 mg, 0.66 mmol). The mixture was placed in a pressure reactor under 50 psig of ethylene pressure and heated at 85 C for 66 hours. The reaction mixture was cooled, vented, and partitioned between phosphate buffer (0.1 M, pH 6.6) and ethyl acetate. The aqueous phase was extracted with ethyl acetate twice more. The combined ethyl acetate extracts were washed with additional phosphate buffer, brine and dried over sodium sulfate. The extracts were filtered and evaporated to afford 2.06 g (63%) of the title product as a flaky crystalline residue. Recrystallization from ethyl acetate/cyclohexane gave colorless flakes. mp 120 – 121 C 1H NMR (CDCl3): delta = 8.55 (br, 1 H); 8.24 (d, 1 H); 8.15 (d, 1 H); 7.76 (d of d, 1 H); 6.64 (d of d, 1 H); 5.73 (d, 1 H); 5.28 (d, 1 H); 2.19 (s, 3 H). MS (Cl): m/z =163 (M+H+).

6163-58-2 Tri-o-tolylphosphine 80271, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Pfizer Products Inc.; EP920864; (1999); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

12150-46-8, 1,1-Bis(diphenylphosphino)ferrocene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

DPPF (55 mg, 0.1 mmol) was added to a rapidly stirred, 10 mlCH2Cl2 suspension of RuCl2(PPh3)3 (96 mg, 0.1 mmol). A colorchange from purple-black to red was observed within a few minutes.The solutionwas stirred for 30 min, then a CH2Cl2 solution of2-aminopyridine (9.4 mg, 0.1 mmol) was added, giving an immediatecolor change to yellow-green. After a further 30 min, thesolvent was removed in vacuo and 5ml of diethyl ether (Et2O) wereadded. The yellow product was filtered off, washed twice withether (2 5 ml), and then dried under vacuum. Yield: 73 mg (93percent).Anal. Calcd for C39H34Cl2N2P2FeRu: C, 57.07; H, 4.15; N, 3.41. Found:C, 56.73; H, 4.16; N, 3.42. 1H NMR (DMSO?d6): 4.32 (s, br. 8H, C5H4),4.55 (s, br. 2H, -NH2, Py), 6.44 (m, 1H, CH, Py), 7.20e7.34 (m, 20H,Ph), 7.38 (m, 1H, CH, Py), 7.87 (m, 1H, CH, Py). 13C{1H} NMR(DMSO?d6): 72.1 (s, C5H4), 75.0 (s, C5H4), 79.1 (s, C5H4), 107.9 (s, Py),111.7 (s, Py), 126.2 (d, 2JC-P 5.0, Ph), 128.7 (d, 1JC-P 6.5, Ph), 133.2(d, 1JC-P 19.0, Ph), 135.8 (d, 1JC-P 98.0, Ph), 136.8 (s, Py), 147.6 (s,Py),. 159.7 (s, Py). 13C{1H,31P} NMR (DMSO?d6): the above 13C{1H }signals became singlets. 31P{1H} NMR (DMSO?d6): 32.34 (br, s). IR(cm1): 3298, 3188, 3102, 3057 (nN-H and nC-H); 1875, 1602, 1533,1478, 1433 (nCC, and C-H, N-H bending), 1154, 1095, 1032, 747, 697

12150-46-8, 12150-46-8 1,1-Bis(diphenylphosphino)ferrocene 51341936, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Ge, Sai; Zhang, Jin; Zhao, Jianguo; Ulhaq, Imran; Ma, Guibin; McDonald, Robert; Journal of Organometallic Chemistry; vol. 879; (2019); p. 7 – 14;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

719-80-2, Ethoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

719-80-2, General procedure: By analogy with 18a from solution alpha-chloroether 16a (1.25 g, 3.8 mmol) in Et2O (1mL) and ethyl diphenylphosphinite 17(0.87 g, 3.8 mmol) compound 18b in 77 % yield (1.44 g) was obtained, m.p. 146-148 C((isooctane).1H NMR (400 MHz, CDCl3, 20 C): delta 3.37(s, 3H, OMe), 5.02 (d, 2JPH= 13.3 Hz, 1H, PCH), 6.56 (s, 1H, CHBr2), 7.15-8.05 (m, 14H, C6H4, 2Ph) ppm. 13C NMR (100.61 MHz, CDCl3, 20 C): delta 40.7 (CHBr2), 59.0 (d, 3JPC= 12.48 Hz, OMe), 83.1 (d, 1JPC= 86.52 Hz, PCH), 128.4, 128.5, 128.6, 128.7, 129.4, 130.3, 130.6, 131.7, 131.8 (CH-aromatic), 128.8, 128.9, 132.3, 132.5, 132.6, 133.2, 135.4, 135.5, 135.6,135.7, 142.5, 142.6 (C-aromatic). 31P NMR (162 MHz, CCl4,20 C): delta 28.2 ppm. Anal. Calcd for C21H19Br2O2P: C, 51.04; H, 3.88; Br, 32.34; P, 6.27. Found: C, 50.81; H, 3.77; Br, 32.18; P, 6.14.

As the paragraph descriping shows that 719-80-2 is playing an increasingly important role.

Reference£º
Article; Gazizov, Mukattis B.; Ivanova, Svetlana Yu.; Bagauva, Liliya R.; Khairullin, Rafail A.; Musin, Rashid Z.; Tetrahedron Letters; vol. 57; 2; (2016); p. 210 – 212;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.607-01-2,Ethyldiphenylphosphine,as a common compound, the synthetic route is as follows.

Accurately weighed ethyl diphenylphosphine (123 muL, 0.6 mmol),1,10-Phenanthroline (0.4698 g, 2.4 mmol) was added to a 25 mL Schlenk reaction flask.Then 3,5-dimethyl iodobenzene (144 muL, 0.9 mmol) was added and the solvent was dichloromethane (2 mL).The reaction was carried out at 75 C for 30 h. After the reaction,Extract with ethyl acetate/water and dry the organic phase with anhydrous sodium sulfate.The solvent was removed under reduced pressure.Separation of silica gel column using petroleum ether/ethyl acetate as eluentThe yield of the product was 40%., 607-01-2

The synthetic route of 607-01-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Dalian University of Technology; Yu Xiaoqiang; Bao Ming; Feng Xiujuan; Yin Qing; (15 pag.)CN109970789; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.564483-19-8,Di-tert-butyl(2′,4′,6′-triisopropyl-[1,1′-biphenyl]-2-yl)phosphine,as a common compound, the synthetic route is as follows.

564483-19-8, Example 73 Synthesis of (R)-3-((3-(5-Amino-3,6,6-trimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenyl)amino)thieno[3,2-b]pyridine-6-carbonitrile A microwave vial was charged with (R)-5-amino-3-(5-bromo-2-fluorophenyl)-3,6,6-trimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide (125 mg, 0.344 mmol), 3-aminothieno[3,2-b]pyridine-6-carbonitrile (90 mg, 0.516 mmol), 2-di-tert-butylphosphino-2′,4′,6′-triisopropylbiphenyl (43.9 mg, 0.103 mmol), sodium tert-butoxide (93 mg, 0.964 mmol), tris(dibenzylideneacetone)dipalladium(0) (31.5 mg, 0.034 mmol), and toluene (1.72 mL). The vial was purged with argon, sealed, and irradiated in a microwave reactor at 100 C. for 1.5 hours. The reaction was diluted with water and extracted with ethyl acetate; the organic layer was concentrated. The crude product was purified via silica gel chromatography, eluting with 20-100% ethyl acetate in hexane, to the title compound (50 mg, 0.109 mmol, 32% yield). LC/MS (ESI+) m/z=458 (M+H). 1H NMR (400 MHz, DMSO-d6) 9.07 (d, J=1.9 Hz, 1H), 9.06 (d, J=1.9 Hz, 1H), 8.46 (s, 1H), 7.52 (dd, J=2.9, 7.2 Hz, 1H), 7.49 (s, 1H), 7.17-7.24 (m, 1H), 7.06 (dd, J=8.8, 11.9 Hz, 1H), 6.09 (br. s., 2H), 3.66 (d, J=15.5 Hz, 1H), 3.51 (d, J=15.5 Hz, 1H), 1.63 (s, 3H), 1.58 (s, 3H), 1.47 (s, 3H).

564483-19-8 Di-tert-butyl(2′,4′,6′-triisopropyl-[1,1′-biphenyl]-2-yl)phosphine 11618717, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; LEWIS, Richard T.; ALLEN, Jennifer R.; CHENG, Yuan; CHOQUETTE, Deborah; EPSTEIN, Oleg; GUZMAN-PEREZ, Angel; HARRINGTON, Paul E.; HUA, Zihao; HUNGATE, Randall W.; HUMAN, Jason Brooks; JUDD, Ted; LIU, Qingyian; LOPEZ, Patricia; MINATTI, Ana Elena; OLIVIERI, Philip; ROMERO, Karina; RUMFELT, Shannon; RZASA, Robert M.; SCHENKEL, Laurie; STELLWAGEN, John; WHITE, Ryan; XUE, Qiufen; ZHENG, Xiao; ZHONG, Wenge; US2014/107109; (2014); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

1070663-78-3, Dicyclohexyl(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1070663-78-3, EXAMPLE TWELVE: Synthesis of Precatalyst 10; Ligand 1 (BrettPhos)An oven-dried schlenk tube, which was equipped with a magnetic stir bar and fitted with a rubber septum, was charged with Me2Pd(TMEDA) (253 mg, 1 mmol) and 1 (537 mg, 1 mmol). The vessel was evacuated and backfilled with argon (this process was repeated a total of 3 times) and the 2-(2-chorophenyl)ethylamine (156 mg, 1 mmol) and MTBE (8 mL) were added via syringe and the reaction mixture was heated to 55 0C for 5 h. The reaction mixture was then cooled to 0 0C and a white precipate was filtered and washed with cold MTBE. The white product was then taken up in CH2Cl2 and concentrated under reduced pressure (done to remove any remaining MTBE) to yield the product as a white solid (645 mg, 93% yield). 1H NMR (300 MHz, CDCl3) delta: 7.17 (s, 2H), 7.09-6.84 (m, 6H), 3.85 (s, 3H), 3.38 (s, 3H), 3.17-0.00 (m, 49 H) ppm. 31P NMR (121 MHz, CDCl3) delta: 42.2 ppm. IR (neat, cm”1): 3303, 2929, 1658, 1462, 1384, 1256, 1010, 755.

As the paragraph descriping shows that 1070663-78-3 is playing an increasingly important role.

Reference£º
Patent; MASSACHUSETTS INSTITUTE OF TECHNOLOGY; WO2009/76622; (2009); A2;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6224-63-1,Tri-m-tolylphosphine,as a common compound, the synthetic route is as follows.

General procedure: Under N2 atmosphere, NaOAc (4.0?equiv), PPh3 1a (0.5?mmol), PdCl2 (10.0?mol?percent), AgOOCCF3 (5.0?equiv), CH3CN (2.0?mL) and methyl acrylate 2a (0.6?mmol) were successively added into a Schlenk reaction tube. Then the mixture was stirred at 60?¡ãC for 24?h. After cooling to room temperature, the solvent was evaporated in vacuo and then purified by flash column chromatography on silica gel to give the pure product 3a., 6224-63-1

The synthetic route of 6224-63-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ma, Ming-Tao; Lu, Jian-Mei; Tetrahedron; vol. 69; 9; (2013); p. 2102 – 2106;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4020-99-9,Methoxydiphenylphosphine,as a common compound, the synthetic route is as follows.

In 1000 ml by adding reaction bottle 99.5g (0.46mol) diphenyl methoxy phosphorus (? 99.5% purity) and 72g m-methoxybenzyl chloride (0.42mol) (content ? 99.2%) making between, under stirring condition temperature to 55 C, and at this temperature thermal insulation 10 hours, and cooled to the end of the 10 C, directly enters the reaction of the next., 4020-99-9

4020-99-9 Methoxydiphenylphosphine 77636, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Suzhou Chenghe Pharmaceutical & Chemical Co., Ltd.; Xia, qiujing; (5 pag.)CN105503954; (2016); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate