17261-28-8, 2-(Diphenylphosphino)benzoic acid is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
17261-28-8, A mixture of DCMOH (156.2 mg, 0.5 mmol), 2-(diphenylphosphino)benzoic acid (183.8 mg, 0.6 mmol), N,N?-dicyclohexylcarbodiimide(288.9 mg, 1.4 mmol) and 4-dimethylaminopyridine (61.1 mg, 0.5 mmol) in anhydrousdichloromethane was stirred at room temperature for 12 h.The residue was filtrated, washed with brine, and extractedwith dichloromethane. The organic layer was dried overanhydrous Na2SO4 and concentrated. The residue was purifiedby silica gel chromatography with dichloromethane/methanol (15:1, v/v) to give DCMHNO as a brown solid(195 mg, 65%). 1H NMR (400 MHz, CDCl3) delta 8.91 (dd, J1=8.4 Hz, J2=1.2 Hz, 1H), 8.31-8.22 (m, 1H), 7.76-7.72 (m,1H), 7.63-7.52 (m, 4H), 7.50-7.42 (m, 3H), 7.41-7.27 (m,10H), 7.06-6.98 (m, 3H), 6.86 (s, 1H), 6.75 (d, J=15.9 Hz,1H). 13C NMR (101 MHz, CDCl3) delta 164.94, 157.26, 152.81,152.32, 152.21, 141.67, 141.39, 137.85, 137.55, 137.44,134.71, 134.52, 134.16, 133.95, 132.76, 132.28, 131.40,128.96, 128.86, 128.65, 128.58, 128.39, 126.02, 125.84,122.49, 118.79, 118.63, 117.84, 116.71, 115.62, 106.98,63.05. HRMS (MALDI-TOF): m/z: [M+K]+ calcd. forC39H25KN2O3P+: 639.1234; found: 639.1444. m.p.232-234 C.
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Reference£º
Article; Wang, Jianguo; Zhu, Wenping; Li, Chunbin; Zhang, Pengfei; Jiang, Guoyu; Niu, Guangle; Tang, Ben Zhong; Science China Chemistry; (2019);,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate