Day: November 18, 2020

18437-78-0, Tris(4-fluorophenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

TFFPP (0.0600 g, 0.189 mmol) was added to a solution of [AuCl(C4H8S)] (0.0146 g, 0.063 mmol) in dichloromethane (20 mL) at -80 ¡ãC and the reaction stirred for 3 h. The solvent was removed by purging nitrogen gas into the solution. The residue was then recrystallized from CH2Cl2/n-hexane mixture for seven days. Partial evaporation of the solvent provided quality crystals. Yield is 98percent. 1H NMR [delta (ppm)]: 7.2(m) and 7.6(m). 31P NMR [delta (ppm)]: 81.1.

18437-78-0, The synthetic route of 18437-78-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Agbeworvi, George; Assefa, Zerihun; Sykora, Richard E.; Taylor, Jared; Crawford, Carlos; Journal of Molecular Structure; vol. 1108; (2016); p. 508 – 515;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6224-63-1, Tri-m-tolylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 1a (70.5 mg, 0.20 mmol), 4-phenylthioxanthone (3 mg, 0.01 mmol), CH3OH (30 mL) were added to a pyrex reaction flash which was equipped with a magnetic stirrer. The mixture was irradiated by a 23 W household lamp at rt under air atmosphere. The photoreaction was completed after 40 minutes as monitored by TLC (eluent: petroleum ether). The solvent was removed and the residue was purified by flash column chromatography on silica gel (eluent: petroleum ether/ethyl acetate = 10/1?EA) to afford 2a as a solid (74 mg, 100%); 1H NMR (400 MHz, CDCl3) delta 7.56 (dd, J = 11.6, 8.8 Hz, 6 H), 6.95 (dd, J = 8.8, 2.0 Hz, 6 H), 3.83 (s, 9 H).

6224-63-1, 6224-63-1 Tri-m-tolylphosphine 80362, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Ding, Aishun; Li, Shijie; Chen, Yang; Jin, Ruiwen; Ye, Cong; Hu, Jianhua; Guo, Hao; Tetrahedron Letters; vol. 59; 43; (2018); p. 3880 – 3883;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1608-26-0,N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine,as a common compound, the synthetic route is as follows.

General procedure: Phosphorus triamides 10a, 10b (5.2 mmol) in 5 cm3 of dryTHF were added in one portion to a mixture of 0.8 g azide1 (3.9 mmol) and 2 cm3 dil. EtOH (1:1) in 10 cm3 THF.The reaction mixture was stirred at r.t. for &6 h (TLC).The solvent was evaporated to dryness; the residue waswashed several times with light petroleum (40-60 C), andcrystallized from the proper solvent to give 13a and 13b,respectively.N00-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-N,N,N?,N?-tetramethylphosphoric triamide(13a, C13H21N4OPS)Pale yellow crystals; yield: 0.97 g (79.6 %); m.p.: 165 C(MeCN); IR (KBr): v = 3325 (NH), 2205 (CN), 1232 (P=O,bonded) cm-1; 1H NMR (500.7 MHz, CDCl3): d = 1.91,2.32 (2 m, 4 9 2H, 4 H2C-hexyl), 2.45 (d, 3JPH = 9.4 Hz,2 9 6H, (Me2N)2P), 11.21 (br, 1H, HN) ppm; 13C NMR(125.4 MHz, CDCl3): d = 150.6 (d, 2JPC = 28.3 Hz, C-NH), 136.1, 130.2 (C=C-hexyl), 113.7 (CN), 87.3 (C-CN),35.5 (d, 2JPC = 13.5 Hz, (Me2N)2P), 26.4, 26.2, 23.5, 21.8(CH2-hexyl) ppm; 31P NMR (200.7 MHz, CDCl3):d = 34.7 ppm; MS (EI, 70 eV): m/z (%) = 311 (45)[M?-1], 285 (34) [M?-27 (H ? CN)], 150 (100) [M?-162 (H ? CN ? C4H12N2OP)]., 1608-26-0

1608-26-0 N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine 15355, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Abdou, Wafaa M.; Ganoub, Neven A.; Sabry, Eman; Monatshefte fur Chemie; vol. 147; 3; (2016); p. 619 – 626;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.932710-63-9,4-(Di-tert-butylphosphino)-N,N-dimethylaniline,as a common compound, the synthetic route is as follows.

932710-63-9, The procedure used to prepare 1a was modified to replace the HgCl2 addition with 0.045 g (0.1 mmol) HgI2. After 1 week, yellow crystals suitable for X-ray analysis were obtained. Yield: 0.052 g,70% based on Hg(SePh)2.Properties: yellow crystalline substance. Melting point: 187-189C. Anal. Calc. for C44H66Hg2I2N2P2Se2 (1497.83): Hg, 26.78;Se, 10.54; C, 35.28; H, 4.44; N, 1.87. Found: Hg, 26.91; Se, 10.62;C, 35.19; H, 4.47; N, 1.84%. IR (KBr): 3051 [vs(CAH)]; 2952[vas(CH3)]; 2872 [vs(CH3)]; 1599, 1472, 1432 [vs(CC)]; 1366[v(CAN)]; 1067, 1022 [dip(CCAH)]; 737, 691 [dop(CCAH)]; 507[v(PAC)]; 466 cm1 [dop(CCAC)] (dip and dop = in-plane and outof-plane bending motions, respectively).

The synthetic route of 932710-63-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Stieler, Rafael; Faoro, Eliandro; Cechin, Camila Nunes; Floriano, Luana; Lang, Ernesto Schulz; Journal of Molecular Structure; vol. 1079; (2014); p. 9 – 14;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.12150-46-8,1,1-Bis(diphenylphosphino)ferrocene,as a common compound, the synthetic route is as follows.

The heteroleptic nickel, palladium and platinum complexes (1?10) were prepared according to the general procedure shown in Scheme 1. To a stirring 15 ml methanolic solution of the ligand K2(p-CH3C6H4SO2N=CS2)¡¤2H2O (0.18 g, 0.5 mmol), K2(p-ClC6H4SO2N=CS2)¡¤2H2O (0.19 g, 0.5 mmol), K2(p-BrC6H4SO2N=CS2)¡¤2H2O (0.21 g, 0.5 mmol) or K2C2H5OCO(CN)CCS2 (0.13 g, 0.5 mmol) a 10ml aqueous solution of NiCl2¡¤6H2O (0.12 g, 0.5 mmol), K2PdCl4 (0.163 g, 0.5 mmol) or K2PtCl4 (0.21 g, 0.5 mmol) was added and in each case the reaction mixture was stirred for half an hour to get a clear solution. To this 25 ml solution was added a 10 ml dichloromethane solution of 1,1?-bis(diphenylphosphino)ferrocene (0.28 g, 0.5 mmol) with vigorous stirring and then further stirred for 12 h in the case of Ni and 24 h for Pd and Pt complexes. The volume of the reaction mixtures were reduced to 15 ml on rotary evaporator and the solid products thus obtained were filtered off and washed with H2O?CH3OH (40:60 v/v) and dried in vacuo over calcium chloride.

12150-46-8, 12150-46-8 1,1-Bis(diphenylphosphino)ferrocene 51341936, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Singh, Santosh K.; Chauhan, Ratna; Diwan, Kiran; Drew, Michael G.B.; Bahadur, Lal; Singh, Nanhai; Journal of Organometallic Chemistry; vol. 745-746; (2013); p. 190 – 200;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13689-20-8,Cyclohexyldiphenylphosphine oxide,as a common compound, the synthetic route is as follows.

General procedure: In a sealed tube containing a solution of the phosphine oxide derivative (5 mmol) in anhydrous toluene (1 M) was added InBr3 (1 mol %, 0.05 mmol) and the TMDS (1.5 equiv, 7.5 mmol) under an argon atmosphere. The reaction mixture was stirred at 100 C during 7-40 h depending on the substrate (the reaction was monitored by 31P NMR). After complete consumption of the reagent the mixture was kept under argon in the sealed tube and cooled to 0 C. A solution of BH3.SMe2 (2 M in THF, 1 equiv) was then slowly added. After 1 h at room temperature, 31P NMR analysis of an aliquot indicates complete conversion to phosphine borane adduct. The crude was poured in an erlenmeyer flask and silica gel was carefully added while stirring. When silica gel was added in the reaction mixture, a slightly exothermic reaction was observed. The reaction mixture was then filtered on silica gel and washed several times with ethyl acetate. After evaporation of the ethyl acetate, the residue was purified by flash chromatography on silica gel with pure cyclohexane to afford the desired phosphine-borane., 13689-20-8

The synthetic route of 13689-20-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Pehlivan, Leyla; Metay, Estelle; Delbrayelle, Dominique; Mignani, Gerard; Lemaire, Marc; Tetrahedron; vol. 68; 15; (2012); p. 3151 – 3155;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

17261-28-8, 2-(Diphenylphosphino)benzoic acid is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

17261-28-8, A mixture of DCMOH (156.2 mg, 0.5 mmol), 2-(diphenylphosphino)benzoic acid (183.8 mg, 0.6 mmol), N,N?-dicyclohexylcarbodiimide(288.9 mg, 1.4 mmol) and 4-dimethylaminopyridine (61.1 mg, 0.5 mmol) in anhydrousdichloromethane was stirred at room temperature for 12 h.The residue was filtrated, washed with brine, and extractedwith dichloromethane. The organic layer was dried overanhydrous Na2SO4 and concentrated. The residue was purifiedby silica gel chromatography with dichloromethane/methanol (15:1, v/v) to give DCMHNO as a brown solid(195 mg, 65%). 1H NMR (400 MHz, CDCl3) delta 8.91 (dd, J1=8.4 Hz, J2=1.2 Hz, 1H), 8.31-8.22 (m, 1H), 7.76-7.72 (m,1H), 7.63-7.52 (m, 4H), 7.50-7.42 (m, 3H), 7.41-7.27 (m,10H), 7.06-6.98 (m, 3H), 6.86 (s, 1H), 6.75 (d, J=15.9 Hz,1H). 13C NMR (101 MHz, CDCl3) delta 164.94, 157.26, 152.81,152.32, 152.21, 141.67, 141.39, 137.85, 137.55, 137.44,134.71, 134.52, 134.16, 133.95, 132.76, 132.28, 131.40,128.96, 128.86, 128.65, 128.58, 128.39, 126.02, 125.84,122.49, 118.79, 118.63, 117.84, 116.71, 115.62, 106.98,63.05. HRMS (MALDI-TOF): m/z: [M+K]+ calcd. forC39H25KN2O3P+: 639.1234; found: 639.1444. m.p.232-234 C.

As the paragraph descriping shows that 17261-28-8 is playing an increasingly important role.

Reference£º
Article; Wang, Jianguo; Zhu, Wenping; Li, Chunbin; Zhang, Pengfei; Jiang, Guoyu; Niu, Guangle; Tang, Ben Zhong; Science China Chemistry; (2019);,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.855-38-9,Tris(4-methoxyphenyl)phosphine,as a common compound, the synthetic route is as follows.,855-38-9

EXAMPLE 20 N-(2,2,2-Trifluoroethyl)-6-[1-methyl-3-(trifluoromethyl)pyrazol-5-yloxy]pyridine-2-carboxamide Analogously to Example 14, 1.39 g (5 mmol) of 2-chloro-6-[1-methyl-3-(trifluoromethyl)-pyrazol-5-yloxy]pyridine, 0.75 g (7.57 mmol, 98 percent content) of 2,2,2-trifluoroethylamine, 0.80 g (7.55 mmol) of anhydrous sodium carbonate, 5.6 mg (25 mumol) of palladium(II) acetate and 88 mg (0.25 mmol) of tris(4-methoxyphenyl)phosphine in 20 ml of methylcyclohexane were reacted under a CO pressure of 21 bar. The yield was 0.96 g (75.4 percent) of a white solid. The melting point was 135.8 to 136.3 C. (from methylcyclohexane). Other data concerning the product was: MS; m/z: 368 (M+); 242 (100 percent) 1 H NMR (CDCl3): delta=3.82 (s, 3H); 4.05 (m, 2H); 6.29 (s, 1H); 7.27 (dt, J=8.1/0.6 Hz, 1H); 7.64 (br. s, 1H); 8.01 (dd, J=7.3/0.5 Hz, 1H); 8.07 (d, J=7.3 Hz, 1H).

The synthetic route of 855-38-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Lonza AG; US5900484; (1999); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

787618-22-8, Dicyclohexyl(2′,6′-diisopropoxy-[1,1′-biphenyl]-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: After purging with argon, a scintillation vial (10 mL), which was equipped with amagnetic stir bar, was charged with RuPhos (1 equiv), the aryl containing drug or the drugderivative, and [(L5-COD)Pd(CT-iSi~1fe3)] (l. l equiv) dissolved in tetrahydrofuran (THF,0.2 M). The closed vial was purged with argon and stined for 16 h. The resulting precipitatewas tlltered, washed with pentane (3 X 3 mL), and dried under reduced pressure to afford theoxidative addition complex (Figure 3). Other potential aryl containing drugs or drugderivatives are shown in Figure 4., 787618-22-8

The synthetic route of 787618-22-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MASSACHUSETTS INSTITUTE OF TECHNOLOGY; BUCHWALD, Stephen, L.; PENTELUTE, Bradley, L.; ZHANG, Chi; (170 pag.)WO2017/151910; (2017); A2;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.18437-78-0,Tris(4-fluorophenyl)phosphine,as a common compound, the synthetic route is as follows.

General procedure: Complex 1 was synthesized by the simultaneous and dropwise addition of tris-(4-fluorophenyl)phosphine(0.316 g, 1 mmol) in acetone and sodium 4-benzylpiperazine-1-carbodithioate (0.274 g, 1 mmol)in methanol to a methanolic suspension of palladium(II) chloride (0.177 g, 1 mmol). The reaction mixturewas refluxed for 5 h with constant stirring. The resulting orange-colored solution was filtered androtary evaporated to obtained orange solid (scheme 1). It was dried and re-dissolved in chloroform,and on slow evaporation needle-like crystals were obtained. Complexes 2 and 3 were synthesized bythe same method (scheme 1).

18437-78-0, The synthetic route of 18437-78-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Khan, Shahan Zeb; Amir, Muhammad Kashif; Abbasi, Rashda; Tahir, Muhammad Nawaz; Zia-ur-Rehman; Journal of Coordination Chemistry; vol. 69; 20; (2016); p. 2999 – 3009;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate