15929-43-8, Bis(4-(trifluoromethyl)phenyl)phosphine oxide is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Weigh 1a (51.2mg, 0.2mmol) and chiral amide 4d(12.6 mg, 0.02 mmol) in a round bottom flask containing a stir bar,Add 0.4 mL of dichloromethane to an ice bath at 0 C;Further taking bis(4-trifluoromethylphenyl)phosphine oxide (67.6 mg, 0.2 mmol)Dissolved in 0.4 mL of dichloromethane and injected into a reaction system of a round bottom flask by a peristaltic pump for 30 minutes. After the injection was completed, the reaction was monitored by TLC.After the reaction was completed, the reaction mixture was concentrated and purified by column chromatography (ethyl ether: ethyl acetate = 1:1) to afford product. The yield was 77% and the enantiomeric excess was 93%., 15929-43-8
The synthetic route of 15929-43-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Guangxi University; Jiang Jun; Gu Xiu; Yuan Hao; Wu Yi; (23 pag.)CN109096334; (2018); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate