Day: November 17, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

50777-76-9, 2-(Diphenylphosphino)benzaldehyde (2.09 g, 7.20 mmol, 1.0 equiv.) and mesitylamine (1.01 g,7.44 mmol, 1.03 mmol) were dissolved in 40 mL toluene. The orange solution was heated to 135 for 20 h under a dropping funnel filled with molecular sieves. Evaporating the solvent in vacuo yielded the product as a yellow solid, which was used in following syntheses without further purication (2.60 g, 6.38 mmol, 89 percent).

The synthetic route of 50777-76-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Vasilenko, Vladislav; Roth, Torsten; Blasius, Clemens K.; Intorp, Sebastian N.; Wadepohl, Hubert; Gade, Lutz H.; Beilstein Journal of Organic Chemistry; vol. 12; (2016); p. 846 – 853;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.63995-70-0,Sodium 3,3′,3”-phosphinetriyltribenzenesulfonate,as a common compound, the synthetic route is as follows.,63995-70-0

General procedure: Palladium complexes were synthetized according to a modified literature procedure [27].Pd(PPh3)4 (103 mg, 0.089 mmol.) was dissolved in 2 g of degassed toluene into a Schlenk tube under nitrogen. The corresponding phosphane (1.5 equiv., 0.133 mmol) was dissolved in 2 g of D2O and cannulated onto the palladium solution. The mixture was stirred for 30 min at room temperature. After decantation, the organic phase was removed and a new degassed Pd(PPh3)4 solution was added to the previous aqueous solution which underwent again a 30 min stirring period to ensure an optimal extraction of the palladium by the hydrosoluble ligand. After decantation, the aqueous phase was recovered. The obtained PdLn (n = 2, 3 or 4) solution was then used for the 31P{1H} NMRstudy. The previous solution usually contained a small excess of free ligand. Study in the presence of RAME-beta-CD was conducted as follow: to 1 mL of the above solution was introduced under nitrogen the required amount of RAME-beta-CD. After 15 min of stirring, the solution was transferred via cannula into a nitrogen pressurized 5 mm NMR tube.

63995-70-0 Sodium 3,3′,3”-phosphinetriyltribenzenesulfonate 6099338, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Ferreira, Michel; Bricout, Herve; Tilloy, Sebastien; Monflier, Eric; Molecules; vol. 22; 1; (2017);,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1079-66-9,Chlorodiphenylphosphine,as a common compound, the synthetic route is as follows.

If the process is carried out in such a manner that the mixture is brought to room temperature after completion of the dropwise addition of chloro(diphenyl)phosphine, then kept under reflux for 12 hours and then worked up as above after cooling, 195 g of ethyl diphenylphosphinite are obtained. This corresponds to a yield of 94% of theory.

1079-66-9, As the paragraph descriping shows that 1079-66-9 is playing an increasingly important role.

Reference£º
Patent; Hoechst Aktiengesellschaft; US5705669; (1998); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1608-26-0,N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine,as a common compound, the synthetic route is as follows.

Trisdimethylaminophosphine 1 (1 mmol)was added to a solution of isatin imine 2a (1 mmol) in dry toluene (30mL), and the resulting mixture was stirring at room temperature for 4 h (TLC) in the presence of atmospheric moisture.[24] After evaporation of the volatile material under reduced pressure, the residue was subjected to silica-gel column chromatography to give the product 4a., 1608-26-0

The synthetic route of 1608-26-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Arsanious, Mona Hizkial Nasr; Maigali, Soher Said; Synthetic Communications; vol. 44; 2; (2014); p. 202 – 214;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

5931-53-3,5931-53-3, Diphenyl(o-tolyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Equimolar amounts of KSeCN (5.8 mg, 0.04 mmol) andeither diphenyl(ortho-tolyl)phosphane (11.1 mg, 0.04 mmol)or dicyclohexyl(ortho-tolyl)phosphane (11.5 mg, 0.04 mmol)were dissolved in the minimum amount of MeOH (10 ml). TheKSeCN solution was added dropwise (over a period of 5 min)to the phosphane solution with stirring at room temperature.Slow evaporation of the solvent afforded the title compoundsas colourless crystals suitable for single-crystal X-ray studies.Analytical data for I, 31P {H} NMR (CDCl3, 161.99 MHz):32.03 [t, 1J(31P-77Se) = 714 Hz]

The synthetic route of 5931-53-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Davis, Wade L.; Muller, Alfred; Acta Crystallographica Section C: Structural Chemistry; vol. 75; (2019); p. 1310 – 1318;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

146960-90-9, 1,1′-Bis(dicyclohexylphosphino)ferrocene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

537 mg (1.73 mmol) of Rh(COD)(acac) was mixed with 10ml of MEK in a small Schlenk flask. To the resulting slurry was added by syringe 0.23 ml of 48% aqueous tetrafluoroboric acid (1.76 mmol) over a period of 2 minutes, resulting in a red solution. After 10 minutes, 0.1 ml (0.83 mmol) of 1 ,5-cyclooctadiene was added by syringe. The brown red slurry was stirred for 20 minutes and then 1g of 1,1′-bis-(dicyclohexylphosphino)ferrocene (DCyPFC) (1.73 mmol) was added. A clear red solution resulted. The stirred solution was then reduced by evaporating MEK solvent. Removal of the ketone solvent was continued until a slurry of the cationic complex in about 3 ml of residual solvent was obtained. To this slurry was added 3 ml of ethanol. The resulting orange slurry was degassed and stripped to about 4 ml of ethanol/MEK. The remaining thick slurry was stirred at room temperature for 1 hour before being filtered and washed with 2×2 ml of cold ethano.. After drying overnight (1 mbar, 2O0C), gave 1.44 g of complex [Rh cod DCyPFC] BF4 , Yield = 95.4 % (1.65 mmol)., 146960-90-9

The synthetic route of 146960-90-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; JOHNSON MATTHEY PUBLIC LIMITED COMPANY; NEDDEN, Hans Guenter; WO2010/1173; (2010); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6372-42-5, Cyclohexyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,6372-42-5

General procedure: 1a (70.5 mg, 0.20 mmol), 4-phenylthioxanthone (3 mg, 0.01 mmol), CH3OH (30 mL) were added to a pyrex reaction flash which was equipped with a magnetic stirrer. The mixture was irradiated by a 23 W household lamp at rt under air atmosphere. The photoreaction was completed after 40 minutes as monitored by TLC (eluent: petroleum ether). The solvent was removed and the residue was purified by flash column chromatography on silica gel (eluent: petroleum ether/ethyl acetate = 10/1?EA) to afford 2a as a solid (74 mg, 100%); 1H NMR (400 MHz, CDCl3) delta 7.56 (dd, J = 11.6, 8.8 Hz, 6 H), 6.95 (dd, J = 8.8, 2.0 Hz, 6 H), 3.83 (s, 9 H).

6372-42-5 Cyclohexyldiphenylphosphine 80756, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Ding, Aishun; Li, Shijie; Chen, Yang; Jin, Ruiwen; Ye, Cong; Hu, Jianhua; Guo, Hao; Tetrahedron Letters; vol. 59; 43; (2018); p. 3880 – 3883;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7688-25-7,1,4-Bis(diphenylphosphino)butane,as a common compound, the synthetic route is as follows.

10. Preparation of 1-Ethyl-4-(2-chloro-3-(2-methoxyethoxy)-4-methylsulfonylbenzoyl)-5-hydroxypyrazole from 1,2-Dichloro-3-(2-methoxyethoxy)-4-methylsulfonylbenzene A solution of 10.0 g (35 mmol) of 1,2-dichloro-3-(2-methoxyethoxy)-4-methylsulfonylbenzene in 500 g of anhydrous dioxane was placed in a 1 L Hastalloy C pressure reactor equipped with a mechanical stirrer and was purged with nitrogen. The following were then added: 7.48 g (70 mmol) of 1-ethyl-5-hydroxypyrazole, 8.16 g (77 mmol of sodium carbonate, 0.195 g (1.75 mmol) of palladium acetate, 0.37 g (1.75 mmol) of 1,4-bisdiphenylphosphinobutane, 0.19 g (0.35 mmol) of hydroquinone, and 0.56 g (3.5 mmol) of tetrabutylammonium bromide. The reactor was sealed and purged three times with carbon monoxide, pressuring to about 200 psi (about 13,800 kiloPascals) each time and was then pressured to 150 psi (10,300 kiloPascals). The mixture was heated to 100-105¡ã C. with stirring, the pressure was adjusted to 175-200 psi (12,000 to 13,800 kiloPascals), and the reaction was allowed to proceed for about 50 hours. About 500 mL of water was added and the bulk of the dioxane was removed by evaporation under reduced pressure. The resulting mixture was filtered to remove spent catalyst, washed twice with 30 mL portions of toluene, and poured slowly with stirring into 200 mL of 10 percent aqueous hydrochloric acid, keeping the temperature at about 60¡ã C. The yellow solution obtained was allowed to cool and the precipitate that formed was collected by filtration, washed with water, and dried to obtain 9.0 g (59 percent of theory) of the title compound., 7688-25-7

The synthetic route of 7688-25-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Dow AgroSciences LLC; US6015911; (2000); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

17261-28-8, 2-(Diphenylphosphino)benzoic acid is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

17261-28-8, General procedure: Triphenylphosphite (2.25g, 7.25mmol) was added portionwise to a stirred mixture of the corresponding amino acid methyl ester hydrochloride (7.15mmol), 2-(diphenylphosphanyl)benzoic acid (2.19g, 7.15mmol), and pyridine (30mL) at 100¡ãC under an argon atmosphere. The reaction mixture was stirred at this temperature for 6h. The excess of pyridine was removed under vacuum. The resulting residue was dissolved in chloroform, washed with water (3 times), saturated aqueous solution of NaHCO3 (3 times), and again with water (2 times). The organic layer was separated, dried over anhydrous Na2SO4, and evaporated to dryness. The resulting residue was purified by column chromatography on silica gel (eluent EtOAc?hexane (1:2)) to give ligands 5a,b as white crystalline solid. 4.2.4.1 Methyl (2R)-2-{[2-(diphenylphosphanyl)benzoyl]amino}-3-(methylsulfanyl)propanoate 5a Yield: 1.25 g (40percent). Mp: 105?108¡ãC. 31P{1H} (121.49 MHz, CDCl3): delta ?9.31 ppm. 1H NMR (400.13 MHz, CDCl3): delta 2.11 (s, 3H, SMe), 2.93 (d, 2H, CH2, 3JHH=5.0 Hz), 3.79 (s, 3H, OMe), 4.92 (dt, 1H, CH, 3JHH=7.6 Hz, 3JHH=5.0 Hz), 6.87 (br d, 1H, NH, 3JHH=7.6 Hz), 7.02 (ddd, 1H, H(C3), 3JHH=7.7 Hz, 3JHP=4.0 Hz, 4JHH=0.8 Hz), 7.29?7.39 (m, 11H, HAr), 7.43 (dt, 1H, H(C5), 3JHH=7.5 Hz, 4JHH=1.2 Hz), 7.70 (ddd, 1H, H(C6), 3JHH=7.5 Hz, 4JHP=3.8 Hz, 4JHH=1.2 Hz) ppm. 13C{1H} NMR (100.61 MHz, CDCl3): delta 16.33 (s, SMe), 36.45 (s, CH2S), 52.04 and 52.64 (both s, OMe and CH), 127.66 (d, C3, 2JCP=4.6 Hz), 128.53 (d, m-C in PPh, 3JCP=6.9 Hz), 128.58 (d, m-C in PPh, 3JCP=6.8 Hz), 128.62 (s, C4 or C5), 128.75 and 128.78 (both s, p-C in PPh2), 130.60 (s, C5 or C4), 133.79 (d, o-C in PPh, 2JCP=3.8 Hz), 133.99 (d, o-C in PPh, 2JCP=3.7 Hz), 134.45 (s, C6), 137.09 (d, C2, 1JCP=22.2 Hz), 137.28 (d, ipso-C in PPh, 1JCP=11.3 Hz), 137.33 (d, ipso-C in PPh, 1JCP=11.0 Hz), 140.15 (d, C1, 2JCP=24.3 Hz), 168.37 (s, C(O)NH), 171.26 (s, C(O)OMe) ppm. IR (KBr, nu/cm?1): 498(w), 518(w), 697(m), 749(s), 999(vw), 1027(vw), 1090(w), 1126(vw), 1159(w), 1176(w), 1214(m), 1258(w), 1311(w), 1434(m), 1459(w), 1479(w), 1520(br, m) (C(O)NH), 1560(vw), 1584(w), 1649(s) (nuC=O in C(O)NH), 1744(s) (nuC=O in C(O)OMe), 2850(vw), 2917(w), 2950(w), 3051(w), 3295(br, w) (nuNH). Anal. Calc. for C24H24NO3PS: C, 65.89; H, 5.53; N, 3.20. Found: C, 66.03; H, 5.49; N, 3.14percent.

As the paragraph descriping shows that 17261-28-8 is playing an increasingly important role.

Reference£º
Article; Churusova, Svetlana G.; Aleksanyan, Diana V.; Rybalkina, Ekaterina Yu.; Nelyubina, Yulia V.; Peregudov, Alexander S.; Klemenkova, Zinaida S.; Kozlov, Vladimir A.; Polyhedron; vol. 143; (2018); p. 70 – 82;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

15929-43-8, Bis(4-(trifluoromethyl)phenyl)phosphine oxide is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Weigh 1a (51.2mg, 0.2mmol) and chiral amide 4d(12.6 mg, 0.02 mmol) in a round bottom flask containing a stir bar,Add 0.4 mL of dichloromethane to an ice bath at 0 C;Further taking bis(4-trifluoromethylphenyl)phosphine oxide (67.6 mg, 0.2 mmol)Dissolved in 0.4 mL of dichloromethane and injected into a reaction system of a round bottom flask by a peristaltic pump for 30 minutes. After the injection was completed, the reaction was monitored by TLC.After the reaction was completed, the reaction mixture was concentrated and purified by column chromatography (ethyl ether: ethyl acetate = 1:1) to afford product. The yield was 77% and the enantiomeric excess was 93%., 15929-43-8

The synthetic route of 15929-43-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Guangxi University; Jiang Jun; Gu Xiu; Yuan Hao; Wu Yi; (23 pag.)CN109096334; (2018); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate