18437-78-0, Tris(4-fluorophenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Under Argon gas protection, add to the flask with stirrer344 mg of Fe2S2(CO)6 (1 mmol) and 15 mL of tetrahydrofuran solvent,A dark red solution was obtained and the resulting solution was cooled down to -78 ¡ãC in a liquid nitrogen bath.2 mL of lithium triethylborohydride (1M in THF) was added slowly with stirring.After 10 minutes of reaction, 0.18 mL of trifluoroacetic acid was added.After the reaction was continued for 15 minutes, 0.18 mL of formaldehyde solution (37percentwt) was added.The reaction was warmed to room temperature and stirred for 3 h before adding 320 mgP(C6H4-4-F)3 (1.0 mmol), stirring for 10 h at room temperature,The tetrahydrofuran solvent was removed by rotary evaporation and 15 mL of dichloromethane and 0.9 mL of concentrated sulfuric acid were added.Continue to stir the reaction for 18 h, add 15 mL of water, and separateDichloromethane in the organic layer was removed by rotary evaporation and the residue was extracted with dichloromethane.Thin layer chromatography was then performed using a developer having a dichloromethane/petroleum ether volume ratio of 1:3.The main band was collected to obtain the model 2 in a yield of 27percent.
18437-78-0, 18437-78-0 Tris(4-fluorophenyl)phosphine 140387, achiral-phosphine-ligands compound, is more and more widely used in various fields.
Reference£º
Patent; Sichuan University of Science and Engineering; Li Yulong; Zou Like; Mu Chao; Deng Chenglong; Wu Yu; Zhao Peihua; Xie Bin; Luo Qiang; (10 pag.)CN106674288; (2017); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate