1079-66-9, Chlorodiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
In a 50 mL three-necked flask equipped with a reflux condenser and a stirrer, 0.32 g (13 mmol) of metal magnesium powder and 3.3 mg (0.013 mmol) of iodine were charged under an argon stream.Stir for 8 hours. ThenA solution prepared by dissolving 1.9 g (11 mmol) of 2-bromotoluene in 10 ml of tetrahydrofuran (THF) was dropped from a dropping funnel.After completion of dropping, the mixture was stirred for 3 hours under reflux of THF. *The obtained 2-toluylmagnesium bromide in THF was cooled to -78 C.,ChlorodiphenylphosphineAfter adding a solution of 3.3 g (15 mmol) dissolved in 2 ml of THF, the temperature was raised to room temperature,Stir for 8 hours.The chloromagnesium bromide precipitated from the obtained reaction mixture was filtered off with a glass filter and washed with 5 ml of pure water and 5 ml of saturated saline. This crude diphenyl (2-toluyl) phosphine solution was dried over magnesium sulfate, and then THF was distilled off, followed by vacuum drying to obtain yellow oily crude diphenyl (2-toluyl) phosphine. The resulting crude diphenyl (2-tolyl) phosphine was purified by flash silica gel chromatography (ethyl acetate / n-hexane)Diphenyl (2-toluyl) phosphine0.88 g (3.2 mmol) was obtained.
1079-66-9, 1079-66-9 Chlorodiphenylphosphine 66180, achiral-phosphine-ligands compound, is more and more widely used in various fields.
Reference£º
Patent; Tosoh Corporation; Tokyo University of Science; Kuramochi, Yusuke; Satake, Shoji; Hara, Oharu; (28 pag.)JP2019/142829; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate