Day: November 16, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4020-99-9,Methoxydiphenylphosphine,as a common compound, the synthetic route is as follows.

General procedure: To a suspension of 1-imidoalkyltriarylphosphonium salt 2 (0.25 mmol, 1.0 equiv.) in CHCl3(2 cm3) placed in a glass vial sealed with a screw-cap a phosphorus nucleophile (2.5 mmol, 10 equiv.)and, in the case of a catalytic reaction, methyltriphenylphosphonium iodide (25.3 mg, 0.0625 mmol,0.25 equiv.) was added. The reaction was carried out under conditions given in Table 1. Then,the solvent was evaporated to dryness under reduced pressure and the product was isolated bycolumn chromatography using 50 cm3 of hexane and then ethyl acetate as the eluent. If necessary,purication can be repeated using acetonitrile or toluene:ethyl acetate (5:1,v/v) as the eluent (this isparticularly useful during the separation of diastereoisomers 1h and 1i). The crystalline compoundswere recrystallized from toluene.

4020-99-9, The synthetic route of 4020-99-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Adamek, Jakub; egrzyk-Schlieter, Anna W.; Ste?, Klaudia; Walczak, Krzysztof; Erfurt, Karol; Molecules; vol. 24; 18; (2019);,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

18437-78-0, Tris(4-fluorophenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Under Argon gas protection, add to the flask with stirrer344 mg of Fe2S2(CO)6 (1 mmol) and 15 mL of tetrahydrofuran solvent,A dark red solution was obtained and the resulting solution was cooled down to -78 ¡ãC in a liquid nitrogen bath.2 mL of lithium triethylborohydride (1M in THF) was added slowly with stirring.After 10 minutes of reaction, 0.18 mL of trifluoroacetic acid was added.After the reaction was continued for 15 minutes, 0.18 mL of formaldehyde solution (37percentwt) was added.The reaction was warmed to room temperature and stirred for 3 h before adding 320 mgP(C6H4-4-F)3 (1.0 mmol), stirring for 10 h at room temperature,The tetrahydrofuran solvent was removed by rotary evaporation and 15 mL of dichloromethane and 0.9 mL of concentrated sulfuric acid were added.Continue to stir the reaction for 18 h, add 15 mL of water, and separateDichloromethane in the organic layer was removed by rotary evaporation and the residue was extracted with dichloromethane.Thin layer chromatography was then performed using a developer having a dichloromethane/petroleum ether volume ratio of 1:3.The main band was collected to obtain the model 2 in a yield of 27percent.

18437-78-0, 18437-78-0 Tris(4-fluorophenyl)phosphine 140387, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Sichuan University of Science and Engineering; Li Yulong; Zou Like; Mu Chao; Deng Chenglong; Wu Yu; Zhao Peihua; Xie Bin; Luo Qiang; (10 pag.)CN106674288; (2017); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13991-08-7, 1,2-Bis(diphenylphosphino)benzene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a MeCN (20 mL) solution of precursor A (106 mg, 0.229 mmol) was added Me3NO¡¤2H2O(65 mg, 0.58 mmol) under N2, resulting in a color change from red to brown, and stirred atroom temperature for about 20 min. A solution of dppbz (120 mg, 0.269 mmol) in MeCN(20 mL) was added to the above brown solution through a catheter and the resulting solutionwas stirred at room temperature for about 2 h and then reuxed at 60 C for about 12 h. Thereaction was monitored by IR spectroscopy to ensure completion. Upon removing the solventunder reduced pressure, the crude product was puried by chromatography on silica gelusing CH2Cl2/petroleum ether (v/v = 4:5) as eluent. Complex 1 was collected as a green solid(72 mg, 33%). IR (KBr disk, cm-1): nuC?O 2019 (vs), 1953 (vs), 1905 (v). 1H NMR (400 MHz, CDCl3,ppm): 1.68 (t, 2 H, 2JHaHe = 3JHaHa? = 12.6 Hz, 2 SCHaHe), 2.03 (m, 1 H, CH), 2.34 (d, 2 H,2JHeHa = 12.4 Hz, 2 SCHaHe), 6.18 (d, 2 H, Ph), 7.03 (m, 3 H, Ph), 7.21-7.26 (m, 8 H, Ph), 7.35-7.42(m, 10 H, Ph), 7.73-7.76 (m, 6 H, Ph). 31P NMR (161.9 MHz, CDCl3, 85% H3PO4, ppm): 88.2 (s).Anal. Calc. for C43H34Fe2O4P2S2: C, 60.58; H, 4.02. Found: C, 60.31; H, 4.30.

13991-08-7, 13991-08-7 1,2-Bis(diphenylphosphino)benzene 498379, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Guo, Ge; Gao, Hui-Ling; Shen, Feng-Sha; Ge, Shi-Wei; Shang, Jing-Yan; Li, Chang-Gong; Journal of Coordination Chemistry; vol. 70; 15; (2017); p. 2695 – 2707;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

719-80-2, Ethoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

719-80-2, 2.90 grams (12 mmol) of 2-(4-fluoro-3-methyl-phenyl)-4,6-dimethylbenzaldehyde (prepared according to Stokker, Jour. Med. Chem. Vol. 29 p.170, 1986) was reduced with 0.454 grams (12 mmol) of sodium borohydride in ethanol (20 mL) at 0 C. The reaction was stirred 1 hr, quenched with aqueous ammonium chloride and the mixture extracted with ether. The organic portion was dried (MgSO4) and concentrated to give 2.90 grams of 2-(4-fluoro-3-methyl-phenyl)-4,6-dimethylbenzyl alcohol as an oil which solidified on standing. The crude solid was treated with 1.31 mL of thionyl chloride and heated on a steam bath for 1 hour. After cooling to room temperature, the crude mixture was taken up in water and extracted with ether. The ether was washed with water and dried(MgSO4), and concentrated to give an oily residue which was purified by silica gel chromatography (25% methylene chloride/ 75% hexane) to give 2-(4-fluoro-3-methyl-phenyl)-4,6-dimethylbenzyl chloride as a solid. 2.06 grams (7.84 mmol) of 2-(4-fluoro-3-methyl-phenyl)-4,6-dimethylbenzyl chloride was treated with ethyldiphenylphosphinite (2.08 grams, 9.01 mmol) and heated to 150C for 3 hrs. After cooling to room temperature, the crude mixture was purified by silicagel chromatography ((10% acetone/90% methylene chloride) and the appropriate fractions concentrated and recrystallized from ether/hexane to provide the title compound (MP 109-111C).

As the paragraph descriping shows that 719-80-2 is playing an increasingly important role.

Reference£º
Patent; Merck & Co., Inc.; EP948335; (2007); B1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13440-07-8,Di(naphthalen-1-yl)phosphine oxide,as a common compound, the synthetic route is as follows.

0.5 mmol of naphthyl diphenylphosphine oxide, 0.25 mmol of potassium carbonate and 0.75 mmol of methyl thiophenol were weighed into 10 mLThe flask was stirred at room temperature for 6 hours. After the reaction, the tetrahydrofuran solvent was removed using a rotary evaporator and the residue was dissolved in lmL of methylene chloride. The residue was purified by silica gel column chromatography to obtain Color transparent liquid, the yield was 87%., 13440-07-8

13440-07-8 Di(naphthalen-1-yl)phosphine oxide 23110917, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Guangdong University of Technology; Yan Xinxing; Chen Qian; Wen Chunxiao; Zeng Jiekun; Huang Yulin; Wang Xiaofeng; Chen Ziming; Huo Yanping; Du Zhiyun; Zhang Kun; (29 pag.)CN106928272; (2017); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.719-80-2,Ethoxydiphenylphosphine,as a common compound, the synthetic route is as follows.

General procedure: To a solution of 1 (0.2 mmol) in 2 mL of CH3CN/H2O(v/v = 100/1) was added Selectfluor (71 mg, 0.2 mmol). The mixture was stirred at room temperature for 5-60minutes. After removal of the solvent, the residue was then purified by flash column chromatography on silica gel with petroleum ether/ethyl acetate to give the desired product 2., 719-80-2

The synthetic route of 719-80-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Chen, Qian; Zeng, Jiekun; Yan, Xinxing; Huang, Yulin; Du, Zhiyun; Zhang, Kun; Wen, Chunxiao; Tetrahedron Letters; vol. 57; 30; (2016); p. 3379 – 3381;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6224-63-1,Tri-m-tolylphosphine,as a common compound, the synthetic route is as follows.

General procedure: The complexes were prepared according to the following method [14]: 1mmol of copper(I) bromide or copper(I) chloride is stirred in methanol until complete dissolution. Then, 2.1 mmol of the corresponding phosphine ligand was added. The mixture was stirred at 60¡ãC for 30min. under nitrogen atmosphere. A microcrystalline precipitate was obtained by concentration of the solution at reduced pressure. The solid product was dissolved in a dichloromethane/methanol mixture and the solution was gradually cooled to 4¡ãC to give an air stable and colorless crystalline solid suitable for X-ray single-crystal diffraction studies., 6224-63-1

The synthetic route of 6224-63-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Espinoza, Sully; Arce, Pablo; San-Martn, Enrique; Lemus, Luis; Costamagna, Juan; Faras, Liliana; Rossi, Miriam; Caruso, Francesco; Guerrero, Juan; Polyhedron; vol. 85; (2015); p. 405 – 411;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.657408-07-6,Dicyclohexyl(2′,6′-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine,as a common compound, the synthetic route is as follows.,657408-07-6

Step 1. The 500 mL round-bottom flask, equipped with magnetic stirrer and reflux condenser was charged with 5-chloro-2-methoxyphenylboronic acid (9.78 g, 52 mmol), 3-amino-2-chloropyridine (7.00 g, 55 mmol), 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl (S-Phos, 0.43 g, 2 mol %), palladium (II) acetate (112 mg, 1 mol %), potassium carbonate (21.7 g, 157 mmol), 180 mL of acetonitrile and 20 ml of water. The flask was filled with nitrogen and heated to reflux under nitrogen atmosphere for 24 hours. Then the reaction was cooled down to room temperature, diluted with 500 mL of water and extracted with ethyl acetate (5*40 mL). Organic fractions were combined, dried over sodium sulfate, filtered and evaporated. The residue was subjected to column chromatography on silica gel with eluent hexane/ethyl acetate gradient mixture, providing 2-(5-chloro-2-methoxyphenyl)pyridin-3-amine as white crystals (9.5 g, NMR confirmed the structure).

The synthetic route of 657408-07-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Universal Display Corporation; US2009/134784; (2009); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17261-28-8,2-(Diphenylphosphino)benzoic acid,as a common compound, the synthetic route is as follows.

General procedure: To a flame dried, 100 mL round bottom flask under nitrogenwere added (1R,2S)-norephedrine (0.750 g, 4.96 mmol) and 4-(dimethylamino)pyridine (0.120 g, 0.990 mmol). The mixture was dissolved in methylene chloride (15 mL). To this solution,N-(3-dimethylaminopropyl)-N’-ethylcarbodiimide hydrochloride (1.07 g, 5.20 mmol) and 2-(diphenylphosphino)benzoic acid (1.59 g, 5.20 mmol) were added and the solution was allowed to stir at room temperature overnight. Methylene chloride (50 mL) was added and the solution was transferred to a separatory funnel and washed with 1 M HCl (50 mL), NH4Cl (50 mL) and with brine(50 mL). The organic extract was dried over anhydrous MgSO4 and the solvent was removed via rotary evaporation. 4.3.5 (1R,2S)-2-Benzamido-1-phenylpropyl 2-(diphenylphosphinyl)benzoate 9a fx14 Purified by recrystallization in CH2Cl2/hexanes to yield 0.702 g (71percent) of product as a white solid. [alpha]D23 = -5.9 (c 1.04, CHCl3). Mp = 77-81 ¡ãC. 1H NMR (400 MHz, CDCl3): delta 0.93 (d, J = 7.0 Hz, 3H), 4.64-4.71 (m, 1H), 6.22 (d, J = 2.9 Hz, 1H), 7.03-7.05 (m, 1H), 7.07 (dd, J = 8.8, 2.5 Hz, 1H), 7.20-7.49 (m, 20H), 7.83 (d, J = 8.3 Hz, 2H), 8.08 (m, 1H). 13C NMR (100 MHz, CDCl3): delta 14.45, 49.63, 79.55, 126.20, 127.28, 127.30, 127.99, 128.48, 128.50, 128.59, 128.66, 128.74, 128.93, 129.00, 130.92, 130.96, 131.38, 132.26, 133.34, 133.53, 133.97, 134.17, 134.63, 134.96, 135.44, 135.67, 137.02, 137.11, 137.15, 137.25, 137.39, 138.57, 138.80, 166.77, 167.03. 31P NMR (162 MHz, CDCl3): delta -5.64. IR v (cm-1, Nujol mull): 1722, 1627, 1247, 753, 695. ESI HRMS for C35H30NO3P: calcd (M+H) 544.2042; found 544.2042., 17261-28-8

The synthetic route of 17261-28-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Nelson, Brandon M.; Chavda, Mihir K.; Oliphant, Jonathan; King, Jalisa M.; Szczepura, Lisa F.; Hitchcock, Shawn R.; Tetrahedron Asymmetry; vol. 27; 20-21; (2016); p. 1075 – 1080;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

1079-66-9, Chlorodiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a 50 mL three-necked flask equipped with a reflux condenser and a stirrer, 0.32 g (13 mmol) of metal magnesium powder and 3.3 mg (0.013 mmol) of iodine were charged under an argon stream.Stir for 8 hours. ThenA solution prepared by dissolving 1.9 g (11 mmol) of 2-bromotoluene in 10 ml of tetrahydrofuran (THF) was dropped from a dropping funnel.After completion of dropping, the mixture was stirred for 3 hours under reflux of THF. *The obtained 2-toluylmagnesium bromide in THF was cooled to -78 C.,ChlorodiphenylphosphineAfter adding a solution of 3.3 g (15 mmol) dissolved in 2 ml of THF, the temperature was raised to room temperature,Stir for 8 hours.The chloromagnesium bromide precipitated from the obtained reaction mixture was filtered off with a glass filter and washed with 5 ml of pure water and 5 ml of saturated saline. This crude diphenyl (2-toluyl) phosphine solution was dried over magnesium sulfate, and then THF was distilled off, followed by vacuum drying to obtain yellow oily crude diphenyl (2-toluyl) phosphine. The resulting crude diphenyl (2-tolyl) phosphine was purified by flash silica gel chromatography (ethyl acetate / n-hexane)Diphenyl (2-toluyl) phosphine0.88 g (3.2 mmol) was obtained.

1079-66-9, 1079-66-9 Chlorodiphenylphosphine 66180, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Tosoh Corporation; Tokyo University of Science; Kuramochi, Yusuke; Satake, Shoji; Hara, Oharu; (28 pag.)JP2019/142829; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate