With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.787618-22-8,Dicyclohexyl(2′,6′-diisopropoxy-[1,1′-biphenyl]-2-yl)phosphine,as a common compound, the synthetic route is as follows.
787618-22-8, Palladium reagents -vvere synthesized following the scheme of Figure 2. Ascintillation vial (J 0 mL), equipped with a magnetic stir bar, was charged vith RuPhos (1.1equiv) or sSPhos (1.1 equiv), Ar–.X (1 equiv), and tetrahydrofuran. Solid [(1,5-COD)Pd(CH2SiMe3)2] (Vinogradova, E. V., et al. Organometallic palladium reagents forcysteine bioconjugation. Nature. 526, 687-691 (2015)) (1 1 equiv) vas added rapidly in oneportion and the resulting solution was stirred for 1 h at 1t. After this time, pentane (3 mL)was added and the resulting mixture was placed into a … 20 C freezer for 2 h. The vial wasremoved from the freezer and, in the air, the resulting precipitate was filtered, washed withpentane (5 x 3 mL), and dried under reduced pressure to afford the oxidative addition complex; Follovving the general procedure, a mixture containing 4-chlorotoluene (6.4 ~LL, 0.054mmol), RuPhos (28 mg, 0.06 mmol), and [(1,5-COD)Pd(CH2SiMe3)2] (25 mg, 0.06 nunol)was stirred at rt in a nitrogen-filled glovebox in cyclohexane (1.5 mL) for 18 h. Generalwork-up afforded A as a grey solid (37 mg, 96%,).
The synthetic route of 787618-22-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MASSACHUSETTS INSTITUTE OF TECHNOLOGY; BUCHWALD, Stephen, L.; PENTELUTE, Bradley, L.; ZHANG, Chi; (170 pag.)WO2017/151910; (2017); A2;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate