7650-91-1, Benzyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
EXAMPLE 9 Preparation of 1,2-Bis[2-(diphenylphosphino)-2-phenyl ethyl]-benzene A 500-mL three-necked flask was equipped with a mechanical stirrer, pressure equalizing dropping funnel, thermometer, and a nitrogen atmosphere. This was charged with 75 mL of THF and diphenylbenzylphosphine (6.0 grams, 21.7 mmole), and the mixture was then cooled to -5 C. N-Butyl lithium (1.55 molar in hexane, 14 mL, 21.7 mmole) was added dropwise to the cold mixture. The resulting dark red solution was stirred at -5 C. for an additional hour. The mixture was then cooled to -78 C. A solution of alpha,alpha’-dichloro-o-xylene (1.75 grams, 10 mmole) in 50 mL of THF was added dropwise to the cold anion solution over 40 minutes. The mixture was stirred at -78 C. for an additional 2 hours, and then it was warmed to 25 C. for 2 more hours. The mixture was quenched with 2 mL of water. The crude mixture was warmed to 70 C. and swept with argon to remove solvent. The residue was treated with a mixture of 200 mL of toluene and 75 ml of 5 percent aqueous hydrochloric acid. The aqueous phase was separated from the toluene layer and discarded. The toluene layer was washed once with 100 mL of water. The toluene solvent was removed by heating to 70 C. at 100 torr under an argon stream. The residue was purified by removing the volatile impurities by distillation with the base temperature reaching 210 C. at 1 torr. The base product (2.6 grams) was an amorphous yellow solid analyzing as follows: 1 H NMR (CDCl3)delta: 2.37-2.93 (multiplet 14H); 3.33-3.78 (multiplet, 2H); 6.33-8.00 (multiplet 34H); 31 P NMR (CDCl3): Two peaks at 0 ppm (Relative to 85 Percent H3 PO4 diasteriomeric pair)., 7650-91-1
As the paragraph descriping shows that 7650-91-1 is playing an increasingly important role.
Reference£º
Patent; Eastmank Kodak Company; US4774362; (1988); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate