Day: November 13, 2020

719-80-2, Ethoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

719-80-2, EXAMPLE 7 Diphenyl(1-ureidobutyl)phosphine oxide STR15 When a mixture of 0.50 mole of ethyl diphenylphosphinite 0.55 mole of n-butyraldehyde, and 0.25 mole of urea in 150 ml of chlorobenzene is warmed at 110 C. for 3 hr, there is only a slow reaction. The mixture is cooled to room temperature and 0.25 mole of acetic acid is added dropwise in ~10 minutes. The temperature increases to 65 during this addition; the urea dissolves and then a white solid product separates. The addition of another 0.25 mole of acetic acid causes no additional heat of reaction. The reaction mixture is warmed at 65-80 for 9.5 hr and filtered, giving 44.4g. Recrystallization from ethylene glycol gives 26.5g of a white solid: mp 241-244; 31 P nmr (CF3 CO2 H) -44.4 ppm; ms M+ = 316 (theory 316). Anal. Calcd for C17 H21 N2 O2 P: N, 8.85; P, 9.79. Found: N, 8.62; P, 9.94.

719-80-2 Ethoxydiphenylphosphine 69754, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Monsanto Company; US4036913; (1977); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.564483-19-8,Di-tert-butyl(2′,4′,6′-triisopropyl-[1,1′-biphenyl]-2-yl)phosphine,as a common compound, the synthetic route is as follows.

564483-19-8, General procedure: [(crotyl)PdCl]2 (197 mg, 0.50 mmol); 22 AgOTf (257 mg, 1.00 mmol); 27 tBuXPhos (425 mg, 1.00 mmol); 2-MeTHF (10.0 mL); 2 h. Product obtained as a slightly yellow solid (722 mg, 98%); The spectral properties are complicated due to the presence of isomers. 1H NMR (400 MHz, CDCl3, delta): Complex spectrum, see FIG. 1; 13C NMR (100 MHz, CDCl3, delta): 153.4, 152.3, 152.0, 146.4, 146.2, 146.0, 145.8, 144.1, 135.0, 134.9, 134.7, 134.4, 134.1, 133.7, 133.6, 133.3, 133.2, 131.5 (2 peaks), 131.4 (2 peaks), 128.1 (2 peaks), 128.0, 127.1, 126.1, 125.7, 124.6, 124.1, 122.9, 122.8, 122.5, 121.7, 121.4, 119.3, 112.9 (2 peaks), 48.3, 38.9, 38.8, 38.3, 38.1, 37.5, 37.3, 33.8, 33.5, 32.0, 31.9, 31.7, 31.6, 31.3, 31.1 (2 peaks), 31.0 (2 peaks), 30.7 (2 peaks), 26.2, 25.6, 25.5, 25.4, 25.1, 24.9, 24.3, 24.2, 24.0 (2 peaks), 23.7, 23.4, 22.8, 16.4 (2 peaks) [Observed complexity due to C-F and C-P coupling]; 19F NMR (372 MHz, CDCl3, delta): -77.9 (s, 3F); 31P NMR (162 MHz, CDCl3, delta): 72.2, 71.7, 66.7; Anal. calcd. for C34H52O3F3PSPd: C, 55.54; H, 7.13. Found C, 55.66; H, 6.99.

564483-19-8 Di-tert-butyl(2′,4′,6′-triisopropyl-[1,1′-biphenyl]-2-yl)phosphine 11618717, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Johnson Matthey Public Limited Company; Colacot, Thomas; Jon Deangelis, Andrew; (66 pag.)US9777030; (2017); B2;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.787618-22-8,Dicyclohexyl(2′,6′-diisopropoxy-[1,1′-biphenyl]-2-yl)phosphine,as a common compound, the synthetic route is as follows.

787618-22-8, Palladium reagents -vvere synthesized following the scheme of Figure 2. Ascintillation vial (J 0 mL), equipped with a magnetic stir bar, was charged vith RuPhos (1.1equiv) or sSPhos (1.1 equiv), Ar–.X (1 equiv), and tetrahydrofuran. Solid [(1,5-COD)Pd(CH2SiMe3)2] (Vinogradova, E. V., et al. Organometallic palladium reagents forcysteine bioconjugation. Nature. 526, 687-691 (2015)) (1 1 equiv) vas added rapidly in oneportion and the resulting solution was stirred for 1 h at 1t. After this time, pentane (3 mL)was added and the resulting mixture was placed into a … 20 C freezer for 2 h. The vial wasremoved from the freezer and, in the air, the resulting precipitate was filtered, washed withpentane (5 x 3 mL), and dried under reduced pressure to afford the oxidative addition complex; Follovving the general procedure, a mixture containing 4-chlorotoluene (6.4 ~LL, 0.054mmol), RuPhos (28 mg, 0.06 mmol), and [(1,5-COD)Pd(CH2SiMe3)2] (25 mg, 0.06 nunol)was stirred at rt in a nitrogen-filled glovebox in cyclohexane (1.5 mL) for 18 h. Generalwork-up afforded A as a grey solid (37 mg, 96%,).

The synthetic route of 787618-22-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MASSACHUSETTS INSTITUTE OF TECHNOLOGY; BUCHWALD, Stephen, L.; PENTELUTE, Bradley, L.; ZHANG, Chi; (170 pag.)WO2017/151910; (2017); A2;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

855-38-9, Tris(4-methoxyphenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,855-38-9

General procedure: To a CH2Cl2 solution of [Cp*Ir(S2C2B10H10)] (B or C) (107mg, 0.2mmol) PR3 (0.2mmol) was added and the mixture was stirred for 10minat ambient temperature. The resulting yellow solution was evaporated in vacuo and the residue was washed with hexanes to give B1-B4, C1-C4, respectively. Single crystals suitable for X-ray analysis were obtained by slow evaporation of a CH2Cl2/hexane solution. (Note: for the preparation of B4 and C4, slight excess of PMe3 was added.)

As the paragraph descriping shows that 855-38-9 is playing an increasingly important role.

Reference£º
Article; Zou, Wenli; Zhang, Xiaolei; Dai, Humin; Yan, Hong; Cremer, Dieter; Kraka, Elfi; Journal of Organometallic Chemistry; vol. 865; (2018); p. 114 – 127;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

7650-91-1, Benzyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 9 Preparation of 1,2-Bis[2-(diphenylphosphino)-2-phenyl ethyl]-benzene A 500-mL three-necked flask was equipped with a mechanical stirrer, pressure equalizing dropping funnel, thermometer, and a nitrogen atmosphere. This was charged with 75 mL of THF and diphenylbenzylphosphine (6.0 grams, 21.7 mmole), and the mixture was then cooled to -5 C. N-Butyl lithium (1.55 molar in hexane, 14 mL, 21.7 mmole) was added dropwise to the cold mixture. The resulting dark red solution was stirred at -5 C. for an additional hour. The mixture was then cooled to -78 C. A solution of alpha,alpha’-dichloro-o-xylene (1.75 grams, 10 mmole) in 50 mL of THF was added dropwise to the cold anion solution over 40 minutes. The mixture was stirred at -78 C. for an additional 2 hours, and then it was warmed to 25 C. for 2 more hours. The mixture was quenched with 2 mL of water. The crude mixture was warmed to 70 C. and swept with argon to remove solvent. The residue was treated with a mixture of 200 mL of toluene and 75 ml of 5 percent aqueous hydrochloric acid. The aqueous phase was separated from the toluene layer and discarded. The toluene layer was washed once with 100 mL of water. The toluene solvent was removed by heating to 70 C. at 100 torr under an argon stream. The residue was purified by removing the volatile impurities by distillation with the base temperature reaching 210 C. at 1 torr. The base product (2.6 grams) was an amorphous yellow solid analyzing as follows: 1 H NMR (CDCl3)delta: 2.37-2.93 (multiplet 14H); 3.33-3.78 (multiplet, 2H); 6.33-8.00 (multiplet 34H); 31 P NMR (CDCl3): Two peaks at 0 ppm (Relative to 85 Percent H3 PO4 diasteriomeric pair)., 7650-91-1

As the paragraph descriping shows that 7650-91-1 is playing an increasingly important role.

Reference£º
Patent; Eastmank Kodak Company; US4774362; (1988); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

166330-10-5, (Oxybis(2,1-phenylene))bis(diphenylphosphine) is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Under a N2 atmosphere, [(CH3CN)4Cu]BF4 (1.0 equiv) and theorganic phosphine ligand (2.0 equiv for PPh3 and TPA-PPP; 1.0equiv for DPEPHOS and XANTPHOS) were mixed in CH2Cl2. Afterstirring for 2 h at room temperature, the corresponding 2,2′-bipyrimidine-based ligand (0.5 equiv) was added. The reaction wasallowed to proceed at room temperature for 4 h. The solvent wasremoved under reduced pressure. The colored residue was dissolvedin CH2Cl2 (2 mL) and precipitated in diethyl ether. Theprecipitation was collected by filtration and washed with diethylether three times. The title Cu(I) complexes were obtained ascolored solids in high yields., 166330-10-5

166330-10-5 (Oxybis(2,1-phenylene))bis(diphenylphosphine) 4285986, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Yang, Xiaolong; Yan, Xiaogang; Guo, Haoran; Liu, Boao; Zhao, Jiang; Zhou, Guijiang; Wu, Yong; Wu, Zhaoxin; Wong, Wai-Yeung; Dyes and Pigments; vol. 143; (2017); p. 151 – 164;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

932710-63-9, 4-(Di-tert-butylphosphino)-N,N-dimethylaniline is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

932710-63-9, The procedure used to prepare 1a was modified to replace the HgCl2 addition with 0.032 g (0.1 mmol) Hg(SCN)2. After 3 days,white crystals suitable for X-ray analysis were obtained. Yield:0.046 g, 68% based on Hg(SePh)2.Properties: white crystalline substance. Melting point: 195-197 C. Anal. Calc. for C46H66Hg2N4P2S2Se2 (1360.18): Hg, 29.49;Se, 11.61; C, 40.62; H, 4.89; N, 4.12. Found: Hg, 29,40; Se, 11.58;C, 40.81; H, 4.83; N, 4.11%. IR (KBr): 3064 [vs(CAH)]; 2951[vas(CH3)]; 2874 [vs(CH3)]; 2101 [v(SCN)]; 1595, 1472, 1435[vs(CC)]; 1370 [v(CAN)]; 1066, 1021 [dip(CCAH)]; 744, 692[dop(CCAH)]; 507 [v(PAC)]; 465 cm1 [dop(CCAC)] (dip anddop = in-plane and out-of-plane bending motions, respectively).

932710-63-9 4-(Di-tert-butylphosphino)-N,N-dimethylaniline 11714598, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Stieler, Rafael; Faoro, Eliandro; Cechin, Camila Nunes; Floriano, Luana; Lang, Ernesto Schulz; Journal of Molecular Structure; vol. 1079; (2014); p. 9 – 14;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.224311-51-7,2-(Di-tert-Butylphosphino)biphenyl,as a common compound, the synthetic route is as follows.

Example 9 A mixture of 5-(3-bromophenoxy)isophthalonitrile (75 mg), 3-hydroxybenzotrifluoride (61 mg), palladium(II) acetate (11 mg), tripotassium phosphate (0.106 g) and 2-(di-tert-butylphosphino)biphenyl (18 mg) in dry toluene was heated at reflux under a nitrogen atmosphere for 24 hours. Water and ethyl acetate were added to the cooled mixture, followed by acidification with aqueous hydrochloric acid (2M). The phases were separated and the organic layer dried over magnesium sulphate, concentrated and purified by flash chromatography. Elution with 5percent ethyl acetate/i-hexane gave 5-[3-(3-trifluoromethylphenoxy)phenoxy]isophthalonitrile (Compound 77, 32 mg), NMR 7.62 (1H, s); 7.52-7.37 (5H, m); 7.31 (1H, s); 7.25 (1H, d); 6.92 (1H, dd); 6.82 (1H, dd); 6.73 (1H, t).

224311-51-7, As the paragraph descriping shows that 224311-51-7 is playing an increasingly important role.

Reference£º
Patent; Cornell, Clive; Cramp, Michael Colin; Gingell, Michael; Westaway, Susan; US2003/181334; (2003); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

1160861-53-9, Di-tert-butyl(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 307. N-(2-Methoxyphenyl)-5-methyl-2-(5-morpholin-4-yl-3,4′-bipyridin-2′-yl)-1H-imidazol-4-amine trifluoroacetate salt To a degassed mixture of 2′-(4-iodo-5-methyl-1H-imidazol-2-yl)-5-morpholin-4-yl-3,4′-bipyridine (30 mg, 0.067 mmol, from Example 257, Step 2), di-tert-butyl(2′,4′,6′-triisopropyl-3,6-dimethoxybiphenyl-2-yl)phosphine (2.0 mg, 0.0040 mmol), tBuBrettPhos Pd G3 (3.4 mg, 0.0040 mmol), and 2-methoxyaniline (9.7 muL, 0.080 mmol) in THF (0.25 mL) was added 1.0 M LHMDS (lithium bis(trimethylsilyl)amide) in THF (150 muL, 0.15 mmol). The mixture was sealed and heated at 70 C. for 2 hours. Upon cooling to room temperature, the reaction mixture was quenched by the addition of 1N HCl (1 mL). The mixture was diluted with ACN/MeOH, filtered, and purified via preparative HPLC/MS (pH 2). Yield: 8.5 mg. 1H NMR (400 MHz, d6-DMSO) delta 8.88 (d, J=5.2 Hz, 1H), 8.58-8.52 (m, 2H), 8.50 (d, J=2.2 Hz, 1H), 8.10-8.02 (m, 1H), 7.87-7.78 (m, 1H), 7.45 (br s, 1H), 7.05-6.95 (m, 1H), 6.86-6.73 (m, 2H), 6.64-6.53 (m, 1H), 3.89 (s, 3H), 3.85-3.72 (m, 4H), 3.43-3.27 (m, 4H), 2.21 (s, 3H). LCMS(M+H)+: 443.1.

1160861-53-9, The synthetic route of 1160861-53-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Incyte Corporation; Sparks, Richard B.; Shepard, Stacey; Combs, Andrew P.; Buesking, Andrew W.; Shao, Lixin; Wang, Haisheng; Falahatpisheh, Nikoo; (158 pag.)US2017/190689; (2017); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

7650-91-1, Benzyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7650-91-1, Pt(tht)2Cl2 (synthesized according to a method disclosed in J. Chem. Soc., Dalton Trans. 1980, 888-894; 100 mg, 1 eq, ?tht? represents tetrahydrothiophene), benzyldiphenylphosphine purchased from Alfa Aesar (68 mg, 1.1 eq), and sodium acetate (94 mg, 5 eq) were added in a 50 mL round-bottomed flask, and degassed xylene (purchased from ECHOChemical; Product no: XA2101-000000-72EC; 6 mL) was then added therein with mixing to obtain a mixture, followed by heating to 100 C. and reacting for 12 hours. The mixture was then cooled to room temperature, and a precursor solution (PS1) of a phosphorescent four-coordinated platinum (II) complex was obtained. 4-(2,6-diisopropylphenyl)-2-(3-trifluoromethyl-1H-pyrazol-5-yl)pyridine (84 mg, 1 eq) was added into the PS1 obtained from Synthesis Example 1 to obtain a mixture, and the mixture was heated to 100 C. and reacted for 6 hours, followed by cooling to room temperature and removing the solvent. Silica-gel column chromatography was conducted to purify the mixture using an eluent of dichloromethane and n-hexane (dichloromethane:n-hexane 1:1). Recrystallization was then conducted using dichloromethane/n-hexane so as to obtain a light yellow crystalline product, referred to as complex E6 (44.3% yield; 85 mg). The reaction scheme for producing the complex E6 is represented as follows: The spectrum analysis for the complex E6 is: 1H NMR (400 MHz, CDCl3, 298 K) delta 8.85 (d, J=8.3 Hz, 1H), 7.85-7.90 (m, 4H), 7.63 (d, J=5.7 Hz, 1H), 7.42-7.51 (m, 7H), 7.35 (t, J=7.8 Hz, 1H), 7.18 (d, J=7.8 Hz, 2H), 7.13-7.16 (m, 2H), 7.00 (t, J=7.4 Hz, 1H), 6.88 (s, 1H), 6.47 (dd, J=1.7, 5.7 Hz, 1H), 3.82 (d, J=11.4 Hz, 2H), 2.41 (hept, J=6.8 Hz, 2H), 1.10 (d, J=6.8 Hz, 6H), 0.99 (d, J=6.8 Hz, 6H), 19F NMR (400 MHz, CDCl3, 298 K) delta -60.7, 31P NMR (200 MHz, CDCl3, 298 K) delta 36.81, FAB-MS m/z 842.9 M+

As the paragraph descriping shows that 7650-91-1 is playing an increasingly important role.

Reference£º
Patent; National Tsing Hua University; Chi, Yun; Huang, Li-Min; US8722885; (2014); B1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate