1608-26-0, N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: Ligand 7 (263.3mg, 0.50mmol) [or 10 (249.3mg, 0.50mmol)] was dissolved in 10mL of anhydrous toluene and cooled to 0C. After the addition of P(NMe2)3 or P(NEt2)3 (0.65mmol), the resulting solution mixture was stirred at 0C for 10min. Next, the reaction mixture was gently warmed to 110C for 6h, and then filtered, concentrated, and purified by preparative TLC on silica gel plates to give the pure product 8a-b [or 11a-b]. Ligand 11a: Yield: 82%; mp: 91-92C. [alpha]D20=+415 (c 0.1, CHCl3). 1H NMR (400MHz, CDCl3) delta 7.79 (dd, J=18.7, 8.1Hz, 2H), 7.60 (dd, J=15.2, 7.6Hz, 4H), 7.48-7.27 (m, 12H), 7.19-7.10 (m, 2H), 5.42 (s, 2H), 5.34 (dd, J=31.4, 11.8Hz, 2H), 2.53 (d, J=9.3Hz, 6H). 13C NMR (100MHz, CDCl3) delta 160.2, 160.1, 148.0, 147.9, 147.7, 140.93, 140.92, 136.94, 136.90, 132.4, 132.1, 131.0, 130.6, 130.44, 130.42, 128.7, 128.6, 128.3, 128.2, 128.0, 127.9, 127.6, 127.5, 127.4, 127.0, 126.9, 125.8, 125.7, 124.9, 124.6, 124.0, 123.9, 122.2, 122.1, 106.7, 106.6, 101.5, 101.4, 72.9, 72.8, 70.1, 68.2, 68.1, 67.9, 39.0, 38.8, 15.0, 14.9. 31P NMR (162MHz, CDCl3) delta 149.30. IR(KBr) nu 3030, 2883, 1592, 1442, 1245, 973, 911, 742, 690cm-1. HRMS (ESI) m/z: Calcd for C36H30NO4P [M+H] +: 572.1985 found: 572.1987, 1608-26-0
As the paragraph descriping shows that 1608-26-0 is playing an increasingly important role.
Reference£º
Article; Zhao, Wenxian; Wang, Tao; Zhao, Ruijuan; Xie, Huanping; Liu, Lantao; Tetrahedron Asymmetry; vol. 27; 4-5; (2016); p. 157 – 162;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate