Day: November 12, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.719-80-2,Ethoxydiphenylphosphine,as a common compound, the synthetic route is as follows.

The reaction flask was evacuated to -0.098 MPa using a vacuum pump.Under this condition will be 23.02gDiphenylethoxyphosphine and 18.26g2,4,6-trimethylbenzoyl chloride was added to the reaction flask, and the reaction was started at a temperature of 40 C.During the reaction, the temperature was raised by 10 C every 20 minutes until the temperature was raised to 90 C.Then react at a constant temperature of 90 C for 8 h.The exhaust gas generated during the reaction is removed by vacuum to the ethyl chloride recovery system and used.After the reaction, 50% ethanol was added to crystallize.33.13 g of the target product TPO were obtained. The purity of the product was 99.2% and the yield was 95.1%., 719-80-2

As the paragraph descriping shows that 719-80-2 is playing an increasingly important role.

Reference£º
Patent; Shaoxing Shangyu Yirui Chemical Co., Ltd.; Li Kunwu; (6 pag.)CN109336925; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

50777-76-9, 2-(Diphenylphosphino)benzaldehyde is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

50777-76-9, General procedure: The iminophosphine ligands were prepared according to the method reported by Shirakawa and co-workers [70]. To 2-(diphenylphosphino)enzaldehyde(1) (200 mg, 0.689 mmol) 0.758 mmol (1.1 M equivalent) of the corresponding amine and 10 mL of freshly distilled toluene were added. The mixture was stirred under reflux (150?160 ¡ãC oil bath temperature) for 6 h.The solvent was removed in vacuo and the crude product was purified by bulb-to-bulb vacuum distillation (170 ¡ãC at 0.05 mm Hg,consistently used for all products) using a Kugel Rohr apparatus into which argon was continuously piped to prevent the ingress of oxygen. Since the iminophosphine products were unstable onsilica, no Rf-values are included for the iminophosphine ligands.

As the paragraph descriping shows that 50777-76-9 is playing an increasingly important role.

Reference£º
Article; Traut-Johnstone, Telisha; Kanyanda, Stonard; Kriel, Frederik H.; Viljoen, Tanya; Kotze, P.D. Riekert; Van Zyl, Werner E.; Coates, Judy; Rees, D. Jasper G.; Meyer, Mervin; Hewer, Raymond; Williams, D. Bradley G.; Journal of Inorganic Biochemistry; vol. 145; (2015); p. 108 – 120;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6224-63-1, Tri-m-tolylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a magnetically stirred solution of a N-formyl/thiourea (2 mmol) and a triarylphosphine (2 mmol) in dry EtOAc (10 mL) was added dropwise, a dialkyl acetylenedicarboxylate (2 mmol) in dry EtOAc (5mL) at room temperature over 10 min. The progress of the reaction was monitored by thin-layer chromatography with n-hexane-ethyl acetate(1:1 v/v) mixture as eluent. After completion of the reaction the solvent was removed under reduced pressure and the solid residue was washed with cold diethyl ether (2 ¡Á 5 mL) and the product was obtained., 6224-63-1

6224-63-1 Tri-m-tolylphosphine 80362, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Shams, Nasim; Mosslemin, Mohammad Hossein; Yazdani, Afshin; Anaraki-Ardakani, Hossein; Ghane, Javad; Journal of Chemical Research; vol. 40; 6; (2016); p. 351 – 353;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

18437-78-0, Tris(4-fluorophenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The synthesis of the cyclopalladated compounds have been carried out using the procedure described by Onue etal. [16] with minor modifications. In a general procedure, to a stirred suspension of [PdCl(C2,N-aphox)]2 (100mg, 0.18mmol) in 10mL of acetone, 0.38mmol of the suitable phosphine ligand (mass of reactants: L1=99.8, L2=120.3, L3=106.7, L4=105.1, L5=134.0, L6=115.8mg) dissolved in 5mL of acetone was added dropwise, affording a yellow solution. The mixture was stirred for 1hat room temperature and slow evaporation of the final solutions at room temperature afforded crystals in good yields. The crystals were collected, washed with pentane and dried under vacuum. Suitable single crystals for X-ray diffraction determination of 1?5 have been obtained by slow evaporation of a solution containing 2?5mg of the complex in 5mL of acetone. Yellow crystals were obtained after 1 week., 18437-78-0

The synthetic route of 18437-78-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Bozza, Gabriela F.; de Farias, Renan L.; de Souza, Ronan F.F.; Rocha, Fillipe V.; Barra, Carolina V.; Deflon, Victor M.; de Almeida, Eduardo T.; Mauro, Antonio E.; Netto, Adelino V.G.; Journal of Molecular Structure; vol. 1175; (2019); p. 195 – 207;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

12150-46-8, 1,1-Bis(diphenylphosphino)ferrocene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The heteroleptic nickel, palladium and platinum complexes (1?10) were prepared according to the general procedure shown in Scheme 1. To a stirring 15 ml methanolic solution of the ligand K2(p-CH3C6H4SO2N=CS2)¡¤2H2O (0.18 g, 0.5 mmol), K2(p-ClC6H4SO2N=CS2)¡¤2H2O (0.19 g, 0.5 mmol), K2(p-BrC6H4SO2N=CS2)¡¤2H2O (0.21 g, 0.5 mmol) or K2C2H5OCO(CN)CCS2 (0.13 g, 0.5 mmol) a 10ml aqueous solution of NiCl2¡¤6H2O (0.12 g, 0.5 mmol), K2PdCl4 (0.163 g, 0.5 mmol) or K2PtCl4 (0.21 g, 0.5 mmol) was added and in each case the reaction mixture was stirred for half an hour to get a clear solution. To this 25 ml solution was added a 10 ml dichloromethane solution of 1,1?-bis(diphenylphosphino)ferrocene (0.28 g, 0.5 mmol) with vigorous stirring and then further stirred for 12 h in the case of Ni and 24 h for Pd and Pt complexes. The volume of the reaction mixtures were reduced to 15 ml on rotary evaporator and the solid products thus obtained were filtered off and washed with H2O?CH3OH (40:60 v/v) and dried in vacuo over calcium chloride.

12150-46-8, The synthetic route of 12150-46-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Singh, Santosh K.; Chauhan, Ratna; Diwan, Kiran; Drew, Michael G.B.; Bahadur, Lal; Singh, Nanhai; Journal of Organometallic Chemistry; vol. 745-746; (2013); p. 190 – 200;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

50777-76-9, The synthesis of the iminophosphine ligand carryingalkoxylsilane moiety A was performed through the reactive distillation of 2-(diphenylphosphino)benzaldehyde(0.500 g) with 3-(aminopropyl)trimethoxysilane (0.250 g)in dry toluene (25 mL). After 5 h, we obtained a yellowoily liquid by careful removal of toluene under vacuum(85 percent yield).1H NMR (400 MHz, CD2Cl2): d = 8.8 (s, 1H), 8.02 (s,1H), 7.45?7.27 (m, 12 H), 6.91 (s, 1 H), 3.53 (s, 9 H), 3.46(m, 2 H), 1.68?1.60 (m, 2 H), 0.58?0.52 (m, 2 H); 13CNMR (100 MHz, CD2Cl2): d = 158.57, 134.14, 128.79,65.13, 50.82, 24.62, 8.73 ppm; 31P NMR: (300 MHz,CD2Cl2, ppm) d = -13.07 ppm.

As the paragraph descriping shows that 50777-76-9 is playing an increasingly important role.

Reference£º
Article; Upadhyay, Praveenkumar Ramprakash; Srivastava, Vivek; Catalysis Letters; vol. 146; 8; (2016); p. 1478 – 1486;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5518-52-5,Tri(furan-2-yl)phosphine,as a common compound, the synthetic route is as follows.

5518-52-5, a 4-Nitrobenzyl (1S,5R,6S)-2-[7-(2-t-butyldimethylsilyloxyethyl)thioimidazo[5,1-b]thiazol-2-yl]-6-((1R)-1-hydroxyethyl)-1-methyl-1-carbapen-2-em-3-carboxylate N,N-Diisopropylethylamine (0.574 ml) was added dropwise to a solution of 791 mg of 4-nitrobenzyl (1R,3R,5R,6S)-6-((1R)-1-hydroxyethyl)-1-methyl-2-oxo-1-carbapenam-3-carboxylate in 20 ml of dry acetonitrile at -30 C. under an argon atmosphere, followed by the dropwise addition of 0.367 ml of trifluoromethanesulfonic anhydride under the same conditions. The mixture was stirred at that temperature for 30 min. Ethyl acetate (40 ml) was then added thereto, and the mixture was washed with semi-saturated brine, a mixed solution composed of semi-saturated brine with a 1 N aqueous hydrochloric acid solution (pH 1.1), a mixed solution composed of semi-saturated brine with a saturated aqueous sodium hydrogencarbonate solution (pH 8.9), and semi-saturated brine in that order, dried over anhydrous magnesium sulfate, and then filtered. The solvent was removed by distillation under the reduced pressure. The residue was dissolved in 10 ml of dry N-methylpyrrolidinone. Tri-2-furylphosphine (11 mg), 104 mg of zinc chloride, 11 mg of tris(dibenzylideneacetone)dipalladium(0), and 1.433 g of 7-(2-t-butyldimethylsilyloxyethyl)thio-2-(tri-n-butylstannyl)imidazo[5,1-b]thiazole were added to the solution. The mixture was stirred at 50 C. under an argon atmosphere for 1.5 hr. Ethyl acetate (30 ml) and 15 ml of a semi-saturated aqueous sodium hydrogencarbonate solution were added to the reaction solution. The mixture was stirred, and the insolubles were removed by filtration. The organic layer was separated from the filtrate, washed with 20 ml of semi-saturated brine three times, and then dried over anhydrous magnesium sulfate. The solvent was removed by distillation under the reduced pressure. The residue was purified by column chromatography on silica gel (dichloromethane:methanol =20:1) to prepare 573 mg of 4-nitrobenzyl (1S,5R,6S)-2-[7-(2-t-butyldimethylsilyloxyethyl)thioimidazo[5,1-b]thiazole-2-yl]-6-((1R)-1-hydroxyethyl)-1-methyl-1-carbapen-2-em-3-carboxylate. NMR (CDCl3) delta: 0.02 (6H, s), 0.86 (9H, s), 1.31 (3H, d, J=7.3 Hz), 1.40 (3H, d, J=6.3 Hz), 2.9-3.0 (2H, m), 3.37 (1H, dd, J1=6.6 Hz, J2=2.8 Hz), 3.4-3.5 (1H, m), 3.75-3.85 (2H, m), 4.25-4.35 (1H, m), 4.38 (1H, dd, J1=9.6 Hz, J22.8 Hz), 5.28 (1H, d, J=13.7 Hz), 5.53 (1H, d, J=13.7 Hz), 7.68 (2H, d, J=8.9 Hz), 8.00 (1H, s), 8.25 (2H, d, J=8.9 Hz), 8.32 (1H, s)

The synthetic route of 5518-52-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Kano, Yuko; Maruyama, Takahisa; Sambongi, Yumiko; Aihara, Kazuhiro; Atsumi, Kunio; Iwamatsu, Kastuyoshi; Ida, Takashi; US2003/27809; (2003); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

1608-26-0, N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Ligand 7 (263.3mg, 0.50mmol) [or 10 (249.3mg, 0.50mmol)] was dissolved in 10mL of anhydrous toluene and cooled to 0C. After the addition of P(NMe2)3 or P(NEt2)3 (0.65mmol), the resulting solution mixture was stirred at 0C for 10min. Next, the reaction mixture was gently warmed to 110C for 6h, and then filtered, concentrated, and purified by preparative TLC on silica gel plates to give the pure product 8a-b [or 11a-b]. Ligand 11a: Yield: 82%; mp: 91-92C. [alpha]D20=+415 (c 0.1, CHCl3). 1H NMR (400MHz, CDCl3) delta 7.79 (dd, J=18.7, 8.1Hz, 2H), 7.60 (dd, J=15.2, 7.6Hz, 4H), 7.48-7.27 (m, 12H), 7.19-7.10 (m, 2H), 5.42 (s, 2H), 5.34 (dd, J=31.4, 11.8Hz, 2H), 2.53 (d, J=9.3Hz, 6H). 13C NMR (100MHz, CDCl3) delta 160.2, 160.1, 148.0, 147.9, 147.7, 140.93, 140.92, 136.94, 136.90, 132.4, 132.1, 131.0, 130.6, 130.44, 130.42, 128.7, 128.6, 128.3, 128.2, 128.0, 127.9, 127.6, 127.5, 127.4, 127.0, 126.9, 125.8, 125.7, 124.9, 124.6, 124.0, 123.9, 122.2, 122.1, 106.7, 106.6, 101.5, 101.4, 72.9, 72.8, 70.1, 68.2, 68.1, 67.9, 39.0, 38.8, 15.0, 14.9. 31P NMR (162MHz, CDCl3) delta 149.30. IR(KBr) nu 3030, 2883, 1592, 1442, 1245, 973, 911, 742, 690cm-1. HRMS (ESI) m/z: Calcd for C36H30NO4P [M+H] +: 572.1985 found: 572.1987, 1608-26-0

As the paragraph descriping shows that 1608-26-0 is playing an increasingly important role.

Reference£º
Article; Zhao, Wenxian; Wang, Tao; Zhao, Ruijuan; Xie, Huanping; Liu, Lantao; Tetrahedron Asymmetry; vol. 27; 4-5; (2016); p. 157 – 162;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6737-42-4,1,3-Bis(diphenylphosphino)propane,as a common compound, the synthetic route is as follows.

6737-42-4, Ethyl-2,2,4,4-tetramethyl chroman-6-carboxylate (Compound 23) A solution of 6-bromo-2,2,4,4-tetramethylchroman (synthesis is described in U.S. Pat. No. 6,252,090)(2.2 g, 8.08 mmol), palladium acetate (0.145 g, 0.65 mmol) and 1,3-bis(diphenylphosphino)propane (0.267 g, 0.65 mmol) in a mixture of N,N-dimethylformamide (25 mL), ethanol (20 mL) and triethyl amine (7 mL) was heated at 90 C. under an atmosphere of carbon monoxide overnight. The volatiles were distilled off in vacuo and the residue was diluted with water and extracted with ethyl acetate. The combined organic extract was washed with brine (*1), dried over anhydrous magnesium sulfate, filtered and evaporated in vacuo to an oil which was subjected to flash column chromatography over silica gel (230-400 mesh) using 5-10% ethyl acetate in hexane as the eluent to afford the title compound (1.9 g, 90%). 1H NMR (300 MHz, CDCl3): delta8.00 (d, 1H, J=2.3 Hz), 7.76 (dd, 1H, J=2.1, 8.5 Hz), 6.79 (d, 1H, J=8.5 Hz), 4.33 (q, 2H, J=7.1 Hz), 1.85 (s, 2H), 1.36 (s, 6H), 1.37 (s, 6H), 1.39-1.33 (m, 3H).

6737-42-4 1,3-Bis(diphenylphosphino)propane 81219, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Vasudevan, Jayasree; Wang, Liming; Liu, Xiaoxia; Tsang, Kwok-Yin; Yuan, Yang-Dar; Chandraratna, Roshantha A.; US2003/207937; (2003); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1608-26-0,N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine,as a common compound, the synthetic route is as follows.

General procedure: Ligand 7 (263.3mg, 0.50mmol) [or 10 (249.3mg, 0.50mmol)] was dissolved in 10mL of anhydrous toluene and cooled to 0C. After the addition of P(NMe2)3 or P(NEt2)3 (0.65mmol), the resulting solution mixture was stirred at 0C for 10min. Next, the reaction mixture was gently warmed to 110C for 6h, and then filtered, concentrated, and purified by preparative TLC on silica gel plates to give the pure product 8a-b [or 11a-b]. Characterization data of new ligand 8a: Yield: 80%; mp: 46-48C. [alpha]D20=+352 (c 0.2, CHCl3). 1H NMR (400MHz, CDCl3) delta 8.12 (s, 2H), 7.92 (dd, J=18.9, 13.6Hz, 2H), 7.50 (t, J=8.5Hz, 4H), 7.44-7.21 (m, 12H), 4.90 (dd, J=27.3, 13.3Hz, 4H), 4.80-4.68 (m, 4H), 2.43-2.28 (m, 6H). 13C NMR (100MHz, CDCl3) delta 147.6, 147.5, 138.4, 138.3, 132.4, 132.0, 131.0, 130.6, 130.5, 130.3, 128.6, 128.5, 128.4, 128.3, 127.8, 127.7, 127.6, 127.5, 126.9, 126.8, 125.8, 125.7, 124.9, 124.7, 124.0, 123.9, 122.7, 73.1, 72.8, 68.12, 68.10, 67.7, 35.6, 35.4. 31P NMR (162MHz, CDCl3) delta 148.62. IR(KBr) nu 3056, 2968, 2963, 2857, 1450, 1350, 1108, 1018, 900, 742, 965cm-1. HRMS (ESI) m/z: Calcd for C38H34NO4P [M+H]+: 600.2304 found: 600.2306, 1608-26-0

1608-26-0 N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine 15355, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Zhao, Wenxian; Wang, Tao; Zhao, Ruijuan; Xie, Huanping; Liu, Lantao; Tetrahedron Asymmetry; vol. 27; 4-5; (2016); p. 157 – 162;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate