With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.240417-00-9,2-Diphenylphosphino-2′-(N,N-dimethylamino)biphenyl,as a common compound, the synthetic route is as follows.
Under argon atmosphere, 1,8-bis(diphenylphosphino)naphthalenedioxide (64.5 mg) was added to 5 mL of the suspension of silver(I) tetrafluoroborate (25.3 mg, 0.130 mmol) in dry dichloromethane, and the mixture was heated to reflux with stirring for one hour. Then, 2-dimethylamino-2′-(diphenylphosphino)biphenyl (49.6 mg, 0.130 mmol) was added to the reaction solution, which was heated to reflux for another one hour. The obtained brown suspension was filtrated, and the filtrate was concentrated and the residue was dissolved in chloroform followed by slow diffusion of diethylether. The precipitate was isolated by filtration, and the filtrated matter was subjected to vacuum drying, thereby providing 101 mg of the pale yellow solid complex. The result of elemental analysis for the obtained complex is shown in Table 2-1, and the composition ratio of the complex was obtained. The present complex corresponds to the above composition formula (1).
240417-00-9, As the paragraph descriping shows that 240417-00-9 is playing an increasingly important role.
Reference£º
Patent; Sumitomo Chemical Company, Limited; EP2360162; (2011); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate