With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17261-28-8,2-(Diphenylphosphino)benzoic acid,as a common compound, the synthetic route is as follows.
To a solution of 2-(diphenylphosphino)benzoic acid (375 mg, 1.23 mmol) in DMF (10 mL) in 0 C. DIPEA (0.4 mL, 2.234 mmol), Compound 1 (640 mg, 1.117 mmol) and HATU (640 mg, 1.675 mmol) was added. The reaction was continued by stirring at RT for 12 h and the reaction was monitored by TLC. After completion of the reaction, the reaction mixture was diluted with water and stirred for 15 minutes. The precipitated solid was filtered off, washed with water and dried in vacuo. Purification of the crude product by column chromatography on silica gel (100-200 mesh) using methanol in DCM (0.5: 9.5) as eluent gave the detector according to the invention as a pale yellow solid (320 mg; 33.20%). Mito-1 was obtained., 17261-28-8
17261-28-8 2-(Diphenylphosphino)benzoic acid 87021, achiral-phosphine-ligands compound, is more and more widely used in various fields.
Reference£º
Patent; Korea University Research Management System; Seon U-gyeong; Sang Ka-peu-rae-sa-deu-beu-heu-ni-ya; Kim Jong-seung; (17 pag.)KR2019/85401; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate