Day: November 9, 2020

12150-46-8, 1,1-Bis(diphenylphosphino)ferrocene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a dichloromethane solution (20 mL) of 1a (20 mg, 0.06 mmol) and dppf (35 mg, 0.06 mmol) was added dropwise a CH2Cl2 solution (10 mL) of Me3NO (5 mg, 0.07 mmol) over a period of 30 min and stirred for an additional 5 h at room temperature. The reaction mixture was then filtered through a short silica column (4 cm). The solvent was removed under reduced pressure and the residue chromatographed by TLC on silica gel. Elution with cyclohexane/dichloromethane (3:7, v/v) developed four bands. The first and second bands were unreacted dppf and phenazine, respectively. The third gave Fe(CO)2) (kappa1-dppf) (eta4-C12H8N2) (5a) (21 mg, 40percent) while the fourth band afforded a trace amount of material insufficient for characterization. Spectral data for 5a: IR (nuCO, CH2Cl2): 1994(vs), 1941(vs) cm-1. 1H NMR (CDCl3): delta 7.43 (m, 20H), 7.23 (m, 4H), 5.91 (m, 2H), 4.45 (m, 2H), 4.22 (m, 2H), 3.86 (m, 2H), 3.70 (m, 2H), 3.06 (m, 2H). 31P{1H} NMR (CDCl3): delta 61.0 (s, 1P) -18.1 (s, 1P). Anal. Calcd. for C48H36Fe2N2O2P2: C, 68.11; H, 4.29; N, 3.31. Found: C, 68.31; H, 4.42; N, 3.46percent.

12150-46-8, The synthetic route of 12150-46-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Chowdhury, Md. Arshad H.; Rahman, Md. Saifur; Islam, Md. Rakibul; Rajbangshi, Subas; Ghosh, Shishir; Hogarth, Graeme; Tocher, Derek A.; Yang, Li; Richmond, Michael G.; Kabir, Shariff E.; Journal of Organometallic Chemistry; vol. 805; (2016); p. 34 – 41;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13440-07-8, Di(naphthalen-1-yl)phosphine oxide is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Add 4-trifluoromethylphenylacetylene to the reaction flask(0.085 g, 0.5 mmol), dinaphthylphosphoric acid(0.30 g, 1 mmol), CuI2 (0.032 g, 0.1 mmol),Phenylisopropyl hydroperoxide (0.46 g, 3 mmol),And N,N-dimethylformamide (2 mL),70oC reaction;TLC tracks the reaction until it is completely over;The crude product obtained after the completion of the reaction was separated by column chromatography (ethyl acetate: petroleum ether = 1:1) to give the desired product.(Yield 82%)., 13440-07-8

The synthetic route of 13440-07-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Nantong Textile Silk Industrial Technology Institute; Soochow University (Suzhou); Zou Jianping; Tao Zekun; Lv Shuaishuai; Li Chengkun; Li Jianan; (12 pag.)CN109096336; (2018); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

17261-28-8, 2-(Diphenylphosphino)benzoic acid is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

N,N’-Dicyclohexylcarbodiimide (163 mg, 0.79 mmol) and 4-dimethylaminopyridine (5 mg, 0.039 mmol) were added to a solution of 2-(diphenylphosphino)benzoic acid (220.0 mg, 0.72 mmol) in anhydrous CH2Cl2 (30 mL) under argon with stirring at room temperature. After 30 min, fluorescein monomethyl ether (249 mg, 0.72 mmol) was added and the resulting mixture was stirred at room temperature overnight. The reaction mixture was concentrated under vacuum and cold acetone was added to dissolve the crude product. The insoluble urea by-product was removed by filtration. The filtrate was concentrated and the residue was purified by silica gel column chromatography (EtOAc /pet.ether=1:2) to provide 1 as a pale yellow solid (280 mg, 61percent)., 17261-28-8

17261-28-8 2-(Diphenylphosphino)benzoic acid 87021, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Miao, Zhengrui; Reisz, Julie A.; Mitroka, Susan M.; Pan, Jia; Xian, Ming; King, S. Bruce; Bioorganic and Medicinal Chemistry Letters; vol. 25; 1; (2015); p. 16 – 19;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13991-08-7,1,2-Bis(diphenylphosphino)benzene,as a common compound, the synthetic route is as follows.

45.6mg mesityl -Cu and 3ml of toluene were added to 48.5mg (0.25mmol) of 7-PyIn and 111.5mg (0.25 mmol) of dppb in a glove box. It forms ayellow solution. It was filtered and coated with a layer of hexane. It formsorange-red crystals. Under UV (356nm), they emit light in a strong orange.Yield: 71%., 13991-08-7

As the paragraph descriping shows that 13991-08-7 is playing an increasingly important role.

Reference£º
Patent; MERCK PATENTGMBH; WESEMANN, LARS; KLEIH, MATTHIAS; MAYER, HERMANN, AUGUST; (72 pag.)JP2016/501830; (2016); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

63995-70-0, Sodium 3,3′,3”-phosphinetriyltribenzenesulfonate is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,63995-70-0

To a solution of AuCl(tht) (417 mg, 1.30 mM) in 70mL methanol was added TPPTS (738.9 mg, 1.30 mM). After being stirred for approximately 40 min, the solution was filtered through Celite and the filtrate was concentrated under vacuum to about 3mL. Addition of diethyl ether precipitated the colorless complex, which was isolated by filtration, washed with diethyl ether, and dried in vacuum. Yield: 1.00 g (95.7%). 1H NMR (D2O): delta 7.54-7.65 (m), 7.87-7.91 (m). 31P{1H} NMR (D2O): delta 33.73 (s).

63995-70-0 Sodium 3,3′,3”-phosphinetriyltribenzenesulfonate 6099338, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Rezsnyak, Chad E.; Autschbach, Jochen; Atwood, Jim D.; Moncho, Salvador; Journal of Coordination Chemistry; vol. 66; 7; (2013); p. 1153 – 1165;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

1608-26-0, N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 816 mg (5 mmol) of tris (dimethylamino) phosphine in 10 mL of dry tetrahydrofuran was stirred at room temperature,1.42 g (10 mmol) of methyl iodide was added to the solution,And the mixture was further stirred at room temperature for 6 hours.After completion of the reaction,The residue obtained by distilling off the solvent was vacuum-dried at 40 C. for 12 hours to obtain 1.54 g (100% yield) of methyltris (dimethylamino) phosphonium iodide as a white powder., 1608-26-0

The synthetic route of 1608-26-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; WAKO PURE CHEMICAL INDUSTRIES LIMITED; AOYAGI, NAOTO; ENDO, TAKESHI; (41 pag.)JP6210065; (2017); B2;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.564483-19-8,Di-tert-butyl(2′,4′,6′-triisopropyl-[1,1′-biphenyl]-2-yl)phosphine,as a common compound, the synthetic route is as follows.

Example 537 26 mg of 5-hydroxy-1-methyl-1H-indole, 64 mg of tripotassium phosphate, 3.8 mg of 2-(di-tert-butylphosphino)-2′,4′,6′-triisopropylbiphenyl and 5.5 mg of tris(dibenzylideneacetone)dipalladium(0) were added to 1.0 mL of toluene solution containing 50 mg of methyl 2-(benzamido)-4-bromobenzoate at room temperature, and the resulting mixture was heated to reflux under nitrogen atmosphere for 2 hours. After the reaction mixture was cooled to room temperature, ethyl acetate and 10% citric acid aqueous solution were added and insoluble were removed by filtration. The organic layer was separated and dried over anhydrous magnesium sulfate after washed with a saturated sodium chloride aqueous solution, and the solvent was evaporated under reduced pressure. The obtained residue was purified with silica gel column chromatography [PSQ100B (spherical) manufactured by Fuji Silysia Chemical Ltd., eluent; hexane: ethyl acetate = 5:1] to obtain 53 mg of methyl 2-(benzamido)-4-(1-methyl-1H-indol-5-yloxy)benzoate as pale yellow solid. 1H-NMR (CDCl3) delta: 3.83 (3H, s), 3.93 (3H, s), 6.47 (1H, dd, J = 3.1, 0.9 Hz), 6.63 (1H, dd, J = 9.0, 2.6 Hz), 7.02 (1H, dd, J = 8.8, 2.2 Hz), 7.10 (1H, d, J = 2.9 Hz), 7.32-7.38 (2H, m), 7.47-7.57 (3H, m), 7.97-8.03 (3H, m), 8.58 (1H, d, J = 2.6 Hz), 12.14 (1H, s)., 564483-19-8

The synthetic route of 564483-19-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; TOYAMA CHEMICAL CO., LTD.; EP1820795; (2007); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

7650-91-1, Benzyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7650-91-1, In the Ar atmosphere,1.0 mmol of the compound of the structure of the formula (3) (wherein R1 and R2 are each independently hydrogen; synthesized by the method of Organometallics 2008, 27, 88-99) were dissolved in 50 mL of anhydrous THF, and then 1.0 mmol of the azide compound of the structure represented by the formula (4) (R3 is a phenyl group, commercially available from ALDRICH) was added,The reaction was stirred at 15 [deg.] C for 12 hours.The resulting reaction solution was concentrated to about 10 ml,2 mL of n-hexane was added (keeping the solution clear).The mixture was stored at -30 overnight,Precipitation ligand.The resulting solid was filtered,Washed with a small amount of n-hexane,Vacuum drying,To obtain ligand L1.Ligand L1 was analyzed,The results are as follows:

The synthetic route of 7650-91-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sinopec China Petroleum & Chemical Corporation; Sinopec Beijing Research Institute of Chemical Industry; Sun, Wei; Xin, Yishuang; Shao, Mingbo; Li, Chuanqing; Wang, Xue; Zhao, Jiangwei; (18 pag.)CN105985382; (2016); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

607-01-2, Ethyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To acetone solution of (diphenylphosphino) ethane (dppe) (0.398 g, 1 mmol) was added 4-nitrophenacyl bromide (0.256 g, 1.05 mmol)and the resulting mixture was stirred for 12 h at room temperature. The resulting yellow solution was filtered off, washed with petroleum diethyl ether, and dried under vacuum. Yield: 0.49 g, 75%; m. p.:220-222 C. Anal. Calc. for C34H30BrNO4P2: C, 62.02; H, 4.59; N, 2.13. Found: C, 62.27; H, 4.61; N, 2.15%. Selected IR absorption in KBr (cm-1): 1684 (nuC=O), 1191 (nuP=O). 31P{1H} NMR (CDCl3): deltaP = 19.45 (d, PCH2, 3JPP = 58.37); 31.66 (d, P(O)Ph2, 3JPP = 54.82). 1H NMR (CDCl3): deltaH = 2.83 (m, 2H, CH2); 3.82 (m, 2H, CH2); 6.32 (d, 1H, PCH2CO, 2JPH = 12.25), 6.52 (d, 1H, PCH2CO, 2JPH = 12.00); 7.18-8.37 (m, 24H, Ph). 13C{1H} NMR (CDCl3): deltaC = 18.06 (t, CH2, 1JPC = 26.03); 36.32 (pseudot, PCH2CO, 1JPC = 29.13); 116.03-134.95 (Ph); 191.31 (s, CO).

607-01-2, Big data shows that 607-01-2 is playing an increasingly important role.

Reference£º
Article; Samiee, Sepideh; Kooti, Nadieh; Gable, Robert W.; Journal of Molecular Structure; vol. 1129; (2017); p. 319 – 324;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

855-38-9, Tris(4-methoxyphenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,855-38-9

General procedure: A solution of (mu3-S)FeCo2(CO)9 (0.069 g, 0.15 mmol) and tris(4-fluorophenyl)phosphane(0.063 g, 0.2 mmol) in CH2Cl2 (10 mL) was added to a solution of Me3NO2H2O (0.022 g,0.2 mmol) and stirred at room temperature for 1 h. The solvent was reduced in vacuo andthe residue was subjected to TLC separation using CH2Cl2:petroleum ether = 1:5 (v/v) aseluent. From the first main brown band, 1 (0.039 g, 35%) was obtained as a black solid. Fromthe second main brown band, 2 (0.040 g, 26%) was obtained as a black solid.

As the paragraph descriping shows that 855-38-9 is playing an increasingly important role.

Reference£º
Article; Zhao, Peng; Liu, Xu-Feng; Wu, Hong-Ke; Journal of Coordination Chemistry; vol. 70; 17; (2017); p. 3080 – 3094;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate