With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.
To a mixture of o-(diphenylphosphino)benzaldehyde (0.86 g, 3.0 mmol) and anhydrous Na2SO4 (10.0 g, 70.0 mmol) in CH2Cl2 (25 mL) was added (R,R)-2-(2,5-dimethyl-pyrrol-1-yl)-cyclohexylamine (0.68 g, 3.5 mmol). The mixture was stirred at room temperature for 3 days. The resulting solution was filtrated and the solvent was removed under vacuum to obtain a yellow solid (R,R)-1 (1.30 g, 93percent yield). Anal. for C31H33N2P: 464.58 g/mol; [alpha]D20 = -36.0 (c 1.0, CH2Cl2)., 50777-76-9
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Reference£º
Article; Zeng, Li; Wu, Fang; Li, Yan-Yun; Dong, Zhen-Rong; Gao, Jing-Xing; Journal of Organometallic Chemistry; vol. 762; (2014); p. 34 – 39;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate