With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7650-91-1,Benzyldiphenylphosphine,as a common compound, the synthetic route is as follows.
7650-91-1, In the Ar atmosphere,1.0 mmol of the compound represented by the formula (3) was obtained(Wherein R1 is methyl and R2 is hydrogen; the synthesis is by the method of Organometallics 2008, 27, 88-99)Was dissolved in 10 mL of anhydrous THF,Then, 1.2 mmol of the azide compound of the structure represented by the formula (4) was added(R3 is 2,4,6-trimethylphenyl, synthesized by the method described in Organometallics 2013, 32, 2300-2308)The reaction was stirred at 25 for 24 hours.The resulting reaction solution was concentrated to about 10 ml,2 mL of n-hexane was added (keeping the solution clear).The mixture was stored at -30 overnight,Precipitation ligand.The resulting solid was filtered,Washed with a small amount of n-hexane,And dried in vacuo to obtain ligand L6.The ligand L6 was analyzed and the results were as follows
7650-91-1 Benzyldiphenylphosphine 603920, achiral-phosphine-ligands compound, is more and more widely used in various fields.
Reference£º
Patent; Sinopec China Petroleum & Chemical Corporation; Sinopec Beijing Research Institute of Chemical Industry; Sun, Wei; Xin, Yishuang; Shao, Mingbo; Li, Chuanqing; Wang, Xue; Zhao, Jiangwei; (18 pag.)CN105985382; (2016); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate