With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.
50777-76-9, Under inert gas protection,50 mL of Schlenk reaction tube was added2,9-dimethyl-4,7-bis (2-thienyl) -1,10-phenanthroline (0.187 g, 0.5 mmol)2- (diphenylphosphino) benzaldehyde (0.291 g, 1 mmol) andPotassium carbonate (50 mmol),Add deoxygenated toluene (20 mL)Rose to 100 ¡ã C for 12 h,Cooled to room temperature, 50 mL of water was added to the reaction solution, the solid was precipitated and filtered,The filtered solid was recrystallized from 1 mL of crystalline solvent methanol,To give the title product 335 mg, yield 73percent
As the paragraph descriping shows that 50777-76-9 is playing an increasingly important role.
Reference£º
Patent; Zhejiang University of Technology; Luo Shuping; Yu Zhejian; Chen Hao; Xia Liangmin; Wang Mingming; Wu Qingan; (8 pag.)CN106749411; (2017); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate