With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4020-99-9,Methoxydiphenylphosphine,as a common compound, the synthetic route is as follows.
To 100ml round-bottomed flask protected from light with aluminum foil, 3-isocyanato-2,4,6-trimethylbenzoyl chloride 3.0 g (13.4mmol) was taken, and after depressurization and purged with nitrogen, dry tetrahydrofuran 50ml was added and dissolved. To this solution, methoxydiphenylphosphine2.7ml (13mmol) was dropped at 65C , and the mixture was stirred for 1.5 hours. The solvent was evaporated under reduced pressure, azeotroped twice with hexane 50ml, and dried under reduced pressure, to give 3-isocyanato-2,4,6-trimethylbenzoyldiphenylphosphineoxidecrude product 5.5g. To 100ml round-bottomed flask protected from light with aluminum foil, methanol 20ml was taken, and after decompression and purged with nitrogen, the mixture was stirred at 40C. Here, 3-isocyanato-2,4,6-trimethylbenzoyldiphenylphosphineoxidecrude product 1.0g was added over 5 min to asolution dissolved in tetrahydrofuran 5ml under nitrogen atmosphere, and stirred at 40 C for 5 hours. After evaporation of the solvent under reduced pressure, under protection from light, it was purified by silica gel column chromatography to give the objective compound 1.0g (97% yield)., 4020-99-9
The synthetic route of 4020-99-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; KurarayNoritakeDentalCo., Ltd.; Tsuruta, Takahiro; Ishino, Hiroshige; (33 pag.)JP5688933; (2015); B2;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate