With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6372-42-5,Cyclohexyldiphenylphosphine,as a common compound, the synthetic route is as follows.,6372-42-5
A solution of silver thiocyanate (0.1146 g, 0.691 mmol) in pyridine (5 mL) was added to asolution of cyclohexyldiphenylphosphine (0.1854 g, 0.691 mmol) in acetonitrile (100 mL).The reaction was heated under reux for 2.5 h. The ltered solution was left to crystallizewhich resulted in an oily product. The oil was dissolved in acetonitrile followed by the removalof the excess of pyridine using a rotary evaporator. Again, an oily product was obtained afterthe acetonitrile evaporated to dryness. Small white crystals were obtained by placing theproduct on the rotary evaporator for 2 h at 95 C. The product yielded 0.2423 g (81%) witha m.p. of 161-164 C. Anal. Calcd for C38H42Ag2N2S2P2: C, 52.55; H, 4.87; N, 3.23; S, 7.38%.Found: C, 52.52; H, 4.96; N, 3.24; S, 7.06%. Solid FTIR (nu, in cm-1): 3045(w) nu(=C-H); 3002(w)nu(C-H); 2089(s) nu(SCN); 1477, 1433(m) nu(C=C); 1384(w); 1326, 1306(w); 1182, 1157(w); 1093(w)nu(P-C); 1025, 996(m) deltaasym (C-H); 848(w) delta(C-H)para; 742, 692(s) delta(C-H)meta. 1H NMR (400 MHz,CDCl3), (delta, in ppm): 1.25 (m, cyclohexyl); 1.51 (m, cyclohexyl); 2.30 (d, 3J(H-H) = 11.6 Hz,cyclohexyl); 7.30 (m, H-aromatic); 7.62 (t, 3J(H-H) = 8.6 Hz, H-aromatic). 13C{H} NMR (100 MHz,CDCl3) (delta, in ppm): 25.73 (para C, cyclohexyl); 26.50 (d, 2J(P-C) = 13.9 Hz, cyclohexyl, ortho C); 28.88 (d, 3 J(P-C) = 6.9 Hz, cyclohexyl, meta C); 35.43 (d, 1J(P-C) = 17.7 Hz, cyclohexyl, ipsoC). 31P{H} NMR (161 MHz, CDCl3) (delta, in ppm): 9.07.
6372-42-5 Cyclohexyldiphenylphosphine 80756, achiral-phosphine-ligands compound, is more and more widely used in various fields.
Reference£º
Article; Potgieter, Kariska; Engelbrecht, Zelinda; Naganagowda, Gadada; Cronje, Marianne J.; Meijboom, Reinout; Journal of Coordination Chemistry; vol. 70; 15; (2017); p. 2644 – 2658;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate