Day: November 6, 2020

6163-58-2, Tri-o-tolylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6163-58-2, (3) Ethyl (2E)-3-[4-(1-{4-[(1E)-3-ethoxy-3-oxo-1-propenyl]phenyl}-5-methyl-1H-pyrrol-2-yl)phenyl]-2-propenoate A solution of 1,2-bis(4-bromophenyl)-5-methyl-1H-pyrrole (2.00 g, 5.115 mmol), ethyl acrylate (1.39 ml, 12.8 mmol), tris(2-methylphenyl)phosphine (125 mg, 0.410 mmol), palladium acetate (23.0 mg, 0.102 mmol) and triethylamine (1.78 ml, 12.8 mmol) in DMF (4 ml) was stirred at 100 C. for 18 hours under nitrogen atmospheric current. The obtained mixture was poured into water and extracted with ethyl acetate. The extract was colleted and washed with water and dried over magnesium sulfate anhydride, and the solvent was removed under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate_hexane=85:15) to give the object compound as a solid. 2.00 g (yield: 91.3%) 1H-NMR (CDCl3) delta; 1.27-1.38 (6H, m), 2.16 (3H, s), 4.21-4.33 (4H, m), 6.12 (1H, d, J=3.4 Hz), 6.28-6.48 (3H, m), 7.04 (2H, d, J=8.4 Hz), 7.17 (2H, d, J=8.4 Hz), 7.30 (2H, d, J=8.4 Hz), 7.52-7.73 (4H, m). IR (KBr) cm-1; 2980, 1713, 1636, 1603, 1514, 1310, 1267, 1204, 1179, 1040, 982, 839, 768, 731.

The synthetic route of 6163-58-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Matsumoto, Takahiro; Katayama, Nozomi; Mabuchi, Hiroshi; US2003/144338; (2003); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

50777-76-9, General procedure: To a mixture of 2-(diphenylphosphino)benzaldehyde(500 mg, 1.72 mmol) and the appropriate amine(1.81 mmol) was added formic acid (1 drop) in MeOH(5 mL). The reaction was allowed to proceed at RT for18 h, at which point the iminophosphine pro-ligand was collected by suction filtration as a pale yellow precipitate. Spectroscopic NMR data were collected in CDCl3 as the pro-ligands decompose in wet DMSO-d6. The spectroscopically pure pro-ligands were used as prepared to make the corresponding platinum(II) complexes.

The synthetic route of 50777-76-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; St-Coeur, Patrick-Denis; Adams, Meghan E.; Kenny, Bryanna J.; Stack, Darcie L.; Vogels, Christopher M.; Masuda, Jason D.; Morin, Pier Jr.; Westcott, Stephen A.; Transition Metal Chemistry; vol. 42; 8; (2017); p. 693 – 701;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

To a mixture of o-(diphenylphosphino)benzaldehyde (0.86 g, 3.0 mmol) and anhydrous Na2SO4 (10.0 g, 70.0 mmol) in CH2Cl2 (25 mL) was added (R,R)-2-(2,5-dimethyl-pyrrol-1-yl)-cyclohexylamine (0.68 g, 3.5 mmol). The mixture was stirred at room temperature for 3 days. The resulting solution was filtrated and the solvent was removed under vacuum to obtain a yellow solid (R,R)-1 (1.30 g, 93percent yield). Anal. for C31H33N2P: 464.58 g/mol; [alpha]D20 = -36.0 (c 1.0, CH2Cl2)., 50777-76-9

Big data shows that 50777-76-9 is playing an increasingly important role.

Reference£º
Article; Zeng, Li; Wu, Fang; Li, Yan-Yun; Dong, Zhen-Rong; Gao, Jing-Xing; Journal of Organometallic Chemistry; vol. 762; (2014); p. 34 – 39;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7650-91-1,Benzyldiphenylphosphine,as a common compound, the synthetic route is as follows.

7650-91-1, In the Ar atmosphere,1.0 mmol of the compound represented by the formula (3) was obtained(Wherein R1 is methyl and R2 is hydrogen; the synthesis is by the method of Organometallics 2008, 27, 88-99)Was dissolved in 10 mL of anhydrous THF,Then, 1.2 mmol of the azide compound of the structure represented by the formula (4) was added(R3 is 2,4,6-trimethylphenyl, synthesized by the method described in Organometallics 2013, 32, 2300-2308)The reaction was stirred at 25 for 24 hours.The resulting reaction solution was concentrated to about 10 ml,2 mL of n-hexane was added (keeping the solution clear).The mixture was stored at -30 overnight,Precipitation ligand.The resulting solid was filtered,Washed with a small amount of n-hexane,And dried in vacuo to obtain ligand L6.The ligand L6 was analyzed and the results were as follows

7650-91-1 Benzyldiphenylphosphine 603920, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Sinopec China Petroleum & Chemical Corporation; Sinopec Beijing Research Institute of Chemical Industry; Sun, Wei; Xin, Yishuang; Shao, Mingbo; Li, Chuanqing; Wang, Xue; Zhao, Jiangwei; (18 pag.)CN105985382; (2016); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6372-42-5,Cyclohexyldiphenylphosphine,as a common compound, the synthetic route is as follows.,6372-42-5

A solution of silver thiocyanate (0.1146 g, 0.691 mmol) in pyridine (5 mL) was added to asolution of cyclohexyldiphenylphosphine (0.1854 g, 0.691 mmol) in acetonitrile (100 mL).The reaction was heated under reux for 2.5 h. The ltered solution was left to crystallizewhich resulted in an oily product. The oil was dissolved in acetonitrile followed by the removalof the excess of pyridine using a rotary evaporator. Again, an oily product was obtained afterthe acetonitrile evaporated to dryness. Small white crystals were obtained by placing theproduct on the rotary evaporator for 2 h at 95 C. The product yielded 0.2423 g (81%) witha m.p. of 161-164 C. Anal. Calcd for C38H42Ag2N2S2P2: C, 52.55; H, 4.87; N, 3.23; S, 7.38%.Found: C, 52.52; H, 4.96; N, 3.24; S, 7.06%. Solid FTIR (nu, in cm-1): 3045(w) nu(=C-H); 3002(w)nu(C-H); 2089(s) nu(SCN); 1477, 1433(m) nu(C=C); 1384(w); 1326, 1306(w); 1182, 1157(w); 1093(w)nu(P-C); 1025, 996(m) deltaasym (C-H); 848(w) delta(C-H)para; 742, 692(s) delta(C-H)meta. 1H NMR (400 MHz,CDCl3), (delta, in ppm): 1.25 (m, cyclohexyl); 1.51 (m, cyclohexyl); 2.30 (d, 3J(H-H) = 11.6 Hz,cyclohexyl); 7.30 (m, H-aromatic); 7.62 (t, 3J(H-H) = 8.6 Hz, H-aromatic). 13C{H} NMR (100 MHz,CDCl3) (delta, in ppm): 25.73 (para C, cyclohexyl); 26.50 (d, 2J(P-C) = 13.9 Hz, cyclohexyl, ortho C); 28.88 (d, 3 J(P-C) = 6.9 Hz, cyclohexyl, meta C); 35.43 (d, 1J(P-C) = 17.7 Hz, cyclohexyl, ipsoC). 31P{H} NMR (161 MHz, CDCl3) (delta, in ppm): 9.07.

6372-42-5 Cyclohexyldiphenylphosphine 80756, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Potgieter, Kariska; Engelbrecht, Zelinda; Naganagowda, Gadada; Cronje, Marianne J.; Meijboom, Reinout; Journal of Coordination Chemistry; vol. 70; 15; (2017); p. 2644 – 2658;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24171-89-9,Tri(thiophen-2-yl)phosphine,as a common compound, the synthetic route is as follows.

A benzene solution (20 mL) of 1 (30 mg, 0.054 mmol) and PTh3 (15 mg, 0.054 mmol) was refluxed for 12 h. The solvent was removed under reduced pressure and the residue chromatographed by TLC on silica gel. Elution with cyclohexane/CH2Cl2 (9:1, v/v) developed three bands. The faster band was unreacted 1 (6 mg), while the second band afforded [Fe2(CO)5(PTh3)(mu-Th)(mu-PTh2)] (2b) (12 mg, 27%) as an orange powder. Spectroscopic data for this band before crystallization showed the presence of a second complex (ca. 10%) that was assigned as [Fe2(CO)5(PTh3)(mu-O=C-Th)(mu-PTh2)] (3b). Recrystallization of the mixture from hexane/CH2Cl2 at 4C gave a crystalline product from which a crystal of [Fe2(CO)5(PTh3)(mu-O=C-Th)(mu-PTh2)] (3b) was selected for crystallography. The third band gave a small amount (ca. 2 mg) of a yellow solid, tentatively identified as [Fe2(CO)6(PTh3)(eta1-Th)(mu-PTh2)]. Spectral data: IR(m(CO), CH2Cl2): 2059 vs, 2018 vs, 1998 s, 1975 w, 1958 br and1895 w. 1H NMR (CDCl3): d 7.88 (d, J 2, 1H), 7.77 (s, 2H), 7.62 (d,J 6, 3H), 7.53 (br, 1H), 7.35 (s, 3H), 7.10 (s, 3H), 6.95 (br, 2H) 6.76(br, 1H), 6.55 (br, 1H), 6.17 (br, 1H). 31P{1H} NMR (CDCl3): d137.0 (d, J 48, P), 40.0 (d, J 48, 1P). Spectral data for 2b: Anal.Calc. for C29H18Fe2O5P2S6: C, 42.87; H, 2.23%. Found: C, 42.91; H,2.25%. IR (m(CO), CH2Cl2): 2038 vs, 1990 s, 1977 sh and 1948 wcm1 1H NMR (CDCl3): d 7.64 (d, J 2.0, 1H), 7.57 (m, 4H), 7.42 (d,J 2.0, 1H), 7.22 (m, 3H), 7.09 (m, 5H), 6.75 (t, J 4.0, 1H) 6.63 (t, J4.0, 1H), 6.37 (m, 1H), 4.79 (d, J 2.0, 1H). 31P{1H} NMR (CDCl3): d92.3 (d, J 24, 1P), 35.0 (d, J 24, 1P). Spectral data for 3b: IR(m(CO), CH2Cl2): 2036 vs, 1981 s, 1952 w and 1934 w cm1.31P{1H} NMR (CDCl3): d 71.7 (d, J 100, 1P), 33.2 (d, J 100, 1P)., 24171-89-9

As the paragraph descriping shows that 24171-89-9 is playing an increasingly important role.

Reference£º
Article; Rahaman, Ahibur; Alam, Fakir Rafiqul; Hossain, Md. Kamal; Abdel-Magied, Ahmed F.; Ghosh, Shishir; Tocher, Derek A.; Haukka, Matti; Kabir, Shariff E.; Nordlander, Ebbe; Hogarth, Graeme; Inorganica Chimica Acta; vol. 430; (2015); p. 208 – 215;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19845-69-3,1,6-Bis(diphenylphosphino)hexane,as a common compound, the synthetic route is as follows.

General procedure: [Cu(CH3CN)4][ClO4] (65.2mg, 0.200mmol) was added to a degassed DCM solution (about 10mL) of BrbpyBr (62.4mg, 0.200mmol) and dppm (78.4mg, 98%, 0.200mmol). The color of the solution gradually changed to pale yellow. The solution was then stirred for 5h at room temperature. After filtration, layering n-hexane onto the DCM solution gave the product as pale yellow crystals., 19845-69-3

19845-69-3 1,6-Bis(diphenylphosphino)hexane 2754312, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Li, Xiu-Ling; Xin, Xue-Lian; Ai, Yu-Bo; Tan, Ming; Lu, Han; Du, Bai-Xiang; Inorganica Chimica Acta; vol. 401; (2013); p. 58 – 63;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4020-99-9,Methoxydiphenylphosphine,as a common compound, the synthetic route is as follows.

To 100ml round-bottomed flask protected from light with aluminum foil, 3-isocyanato-2,4,6-trimethylbenzoyl chloride 3.0 g (13.4mmol) was taken, and after depressurization and purged with nitrogen, dry tetrahydrofuran 50ml was added and dissolved. To this solution, methoxydiphenylphosphine2.7ml (13mmol) was dropped at 65C , and the mixture was stirred for 1.5 hours. The solvent was evaporated under reduced pressure, azeotroped twice with hexane 50ml, and dried under reduced pressure, to give 3-isocyanato-2,4,6-trimethylbenzoyldiphenylphosphineoxidecrude product 5.5g. To 100ml round-bottomed flask protected from light with aluminum foil, methanol 20ml was taken, and after decompression and purged with nitrogen, the mixture was stirred at 40C. Here, 3-isocyanato-2,4,6-trimethylbenzoyldiphenylphosphineoxidecrude product 1.0g was added over 5 min to asolution dissolved in tetrahydrofuran 5ml under nitrogen atmosphere, and stirred at 40 C for 5 hours. After evaporation of the solvent under reduced pressure, under protection from light, it was purified by silica gel column chromatography to give the objective compound 1.0g (97% yield)., 4020-99-9

The synthetic route of 4020-99-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; KurarayNoritakeDentalCo., Ltd.; Tsuruta, Takahiro; Ishino, Hiroshige; (33 pag.)JP5688933; (2015); B2;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.166330-10-5,(Oxybis(2,1-phenylene))bis(diphenylphosphine),as a common compound, the synthetic route is as follows.

General procedure: A mixture of 0.0630 g [Cu(CH3CN)4]BF4 (0.2 mmol), 0.0464 gdpq (0.2 mmol) and 0.1157 g xantphos (0.2 mmol) were dissolved in the mixed solvents of 5 mL CH3OH and 5 mL CH2Cl2, stirred atroom temperature for 6 h. The filtrate was evaporated slowly at room temperature for around 4 days to yield yellow crystalline products. Yield: 80%. Anal. Calc. for C55H49BCuF4N4O3.50P2: C,63.87; H, 4.78; N, 5.42. Found: C, 65.11; H, 4.16; N, 5.76%., 166330-10-5

As the paragraph descriping shows that 166330-10-5 is playing an increasingly important role.

Reference£º
Article; Kuang, Xiao-Nan; Lin, Sen; Liu, Jian-Ming; Han, Hong-Liang; Liu, Min; Xin, Xiu-Lan; Yang, Yu-Ping; Li, Zhong-Feng; Jin, Qiong-Hua; Li, Si-Fan; Li, Yue-Xue; Feng, Yue-Bing; Polyhedron; vol. 165; (2019); p. 51 – 62;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

50777-76-9, Under inert gas protection,50 mL of Schlenk reaction tube was added2,9-dimethyl-4,7-bis (2-thienyl) -1,10-phenanthroline (0.187 g, 0.5 mmol)2- (diphenylphosphino) benzaldehyde (0.291 g, 1 mmol) andPotassium carbonate (50 mmol),Add deoxygenated toluene (20 mL)Rose to 100 ¡ã C for 12 h,Cooled to room temperature, 50 mL of water was added to the reaction solution, the solid was precipitated and filtered,The filtered solid was recrystallized from 1 mL of crystalline solvent methanol,To give the title product 335 mg, yield 73percent

As the paragraph descriping shows that 50777-76-9 is playing an increasingly important role.

Reference£º
Patent; Zhejiang University of Technology; Luo Shuping; Yu Zhejian; Chen Hao; Xia Liangmin; Wang Mingming; Wu Qingan; (8 pag.)CN106749411; (2017); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate