With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19845-69-3,1,6-Bis(diphenylphosphino)hexane,as a common compound, the synthetic route is as follows.
1,6-bis (diphenylphosphino) hexane (1.37 g, 3 mmol),10- (4-bromophenoxy) decanol (3.9 g, 12 mmol),Ethylene glycol 10mL and nickel bromide 50mg added to a 50mL three-necked flask and purged with nitrogen,The temperature was raised to 180 C.After 4h magnetic stirring reaction system,After cooling, all the reactants were dissolved in 20 mL of dichloromethane,The organic layer was washed three times with deionized water.After the solution was dried over anhydrous Na2SO4 filtered,The organic phase was washed with a large amount of ether and a large amount of tetrahydrofuran respectively,Compound B3 is then obtained., 19845-69-3
The synthetic route of 19845-69-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Beijing University of Chemical Technology; Wang Zhongming; Yang Qian; Han Kefei; Zhu Hong; (9 pag.)CN107347909; (2017); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate