787618-22-8, Dicyclohexyl(2′,6′-diisopropoxy-[1,1′-biphenyl]-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
787618-22-8, [Step 4] tert-Butyl 7-methyl-8-(4-methylpiperazin-1-yl)-5-oxo-1,5-dihydro-2H-chromeno[3,4-c]pyridine-3(4H)-carboxylate To a suspension of tert-butyl 7-methyl-5-oxo-8-{[(trifluoromethyl) sulfonyl]oxy}-1,5-dihydro-2H-chromeno[3,4-c]pyridine-3(4H)-carboxylate (5.60 g) in toluene (100 ml), cesium carbonate (5.91 g), chloro-(2-dicyclohexylphosphino-2′,6′-diisopropoxy-1,1′-biphenyl)[2-(2-aminoethyl)phenyl]palladium (II)-methyl-t-butyl ether adduct (250 mg), 2-dicyclohexylphosphino-2′,6′-diisopropoxybiphenyl (141 mg) and 1-methylpiperazine (3.33 ml) were added. The reaction solution was stirred in a nitrogen atmosphere at 110 C. for 8 hours while heating. The reaction solution was diluted with chloroform and a small volume of methanol and filtered with Celite. The reaction solution, to which water and saturated saline were added, was extracted with chloroform and a small volume of methanol. The organic layer was dried over anhydrous sodium sulfate and then filtered. The filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (1-10% methanol/chloroform) to obtain the title compound (4.59 g) as a solid. 1H-NMR (CDCl3) delta: 7.36 (1H, d, J=8.5 Hz), 6.99 (1H, d, J=8.5 Hz), 4.40 (2H, s), 3.72 (2H, t, J=5.8 Hz), 3.02 (4H, t, J=4.6 Hz), 2.88-2.82 (2H, m), 2.66-2.57 (2H, m), 2.38 (6H, s), 1.66-1.59 (2H, m), 1.49 (9H, s). MS (ESI/APCI) m/z: 414 [M+H]+
787618-22-8 Dicyclohexyl(2′,6′-diisopropoxy-[1,1′-biphenyl]-2-yl)phosphine 121592071, achiral-phosphine-ligands compound, is more and more widely used in various fields.
Reference£º
Patent; Daiichi Sankyo Company, Limited; Ota, Masahiro; Inoue, Hidekazu; Kawai, Junya; Ohki, Hitoshi; Toki, Tadashi; (25 pag.)US2019/284198; (2019); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate