With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6224-63-1,Tri-m-tolylphosphine,as a common compound, the synthetic route is as follows.
Under inert gas protection, 344 mg of Fe2S2(CO)6 (1 mmol) and 20 mL of tetrahydrofuran solvent were added to the flask containing the stirring magnets.A dark red solution was obtained, and the obtained solution was cooled to -78 ¡ã C with a liquid nitrogen bath, and 2 mL of a lithium triethylborohydride (1M in THF) solution was slowly added under stirring.After reacting for 15 min, 0.18 mL of trifluoroacetic acid (2.2 mmol) was added and the reaction was continued for 15 min.Add 304 mg of P(C6H4-3-CH3)3 (1.0 mmol), stir at room temperature for 3 h, then add 630 mg of I-4-C6H4N(CH2Cl)2 (2 mmol) and 0.28 mL of triethylamine.The reaction was stirred at room temperature for 12 h. The tetrahydrofuran solvent was removed by rotary evaporation, and the residue was extracted with dichloromethane.Then, thin layer chromatography was carried out using a developing solvent of dichloromethane/petroleum ether in a volume ratio of 1:6, and the main ribbon was collected to obtain a model 3.
6224-63-1, 6224-63-1 Tri-m-tolylphosphine 80362, achiral-phosphine-ligands compound, is more and more widely used in various fields.
Reference£º
Patent; Sichuan University of Science and Engineering; Li Yulong; He Jiao; Wu Yu; Xie Ying; Jiang Jin; Sun Yanchun; Wang Zheng; Zou Like; Xie Bin; Gao Fan; Mu Chao; (11 pag.)CN109232665; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate