With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1070663-78-3,Dicyclohexyl(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine,as a common compound, the synthetic route is as follows.
1070663-78-3, [(i3-indenyl)Pd(.i-OTf)j2 (0.10 g, 0.135 mmol) and BrettPhos (0.145 g, 0.270 mmol) were added to a 20 mL vial equipped with a flea stir bar. THF (10 mL) was added to the vialand a red homogenous mixture was observed. The mixture was stirred for one hour at room temperature, at which time the solvent was removed under reduced pressure. The red oil was titrated with pentane to yield a dark red solid. Yield: 0.220 g, 90%. 1H NMR (CDCl3, 500 MHz): 7.44 (s, 1H), 7.16-6.93 (m, 7H), 6.82 (d, J = 6.5 Hz, 1H), 6.63 (s, 1H), 6.06 (s, 1H), 4.17 (d, 5.4 Hz, 1H), 3.92 (s, 3H), 3.33 (s, 3H), 3.15 (sept, J = 5.6 Hz, 1H), 2.79 (q, J = 5.7Hz, 1H), 2.56 (q, J = 5.7 Hz, 1H), 2.27-1.67 (m, 16H), 1.54-0.81 (m, 20H), 0.69 (d, J = 6.1Hz, 3H), 0.45 (d, J = 6.2 Hz, 3H) ppm. 13C{1H} NMR (126 MHz, CDCl3): 154.85, 154.17,153.51, 151.21, 151.08, 150.96, 139.93, 139.89, 135.74, 135.33, 134.74, 134.58, 129.16,127.13, 125.74, 125.47, 124.60, 122.89, 122.59, 120.93, 119.38, 116.60, 116.43, 115.46,114.21, 114.16, 112.88, 112.84, 109.62, 109.58, 70.76, 67.95, 56.04, 54.71, 39.16, 38.98,38.71, 38.51, 34.38, 34.19, 32.77, 32.21, 31.94, 30.53, 30.51, 30.30, 29.79, 29.24, 27.35,27.25, 27.09, 26.99, 26.87, 26.79, 26.75, 26.67, 26.42, 25.83, 24.93, 24.61, 24.31, 24.16,23.85 ppm. 31P{1H} NMR (CDCl3 100 MHz): 58.19 ppm. 19F NMR (471 MHz, CDCl3):-78.01 ppm.
As the paragraph descriping shows that 1070663-78-3 is playing an increasingly important role.
Reference£º
Patent; YALE UNIVERSITY; HAZARI, Nilay; MELVIN, Patrick; (59 pag.)WO2018/183328; (2018); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate