Day: November 4, 2020

1608-26-0, N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Tris(dimethylamino)phosphine (2.29 g, 14 mmol) was added drop-wise to a stirred solution of 2-methylprop-2-en-1-ol (1 g, 14 mmol) and CCl4 (2.46 g, 16 mmol) in dry CH2Cl2 (30 mL) cooled at -30 C. Then, 15 mL of distilled water was added and the reaction mixture was allowed to proceed at room temperature for 2 h. Organic phase was decanted and extracted with water (2 * 40 mL). Aqueous phases were collected, washed with Et2O and decanted to give an aqueous solution of methallyloxyphosphonium chloride. After the addition of KPF6 (3.68 g, 20 mmol) in 10 mL of water, an immediate precipitate was formed. The mixture was filtered and the crude product was washed with Et2O and dried under vacuum. Recrystallization from a mixture of chloroform: Et2O solution afforded salt 2 as a white solid., 1608-26-0

1608-26-0 N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine 15355, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Dridi, Sana; Mechria, Ali; Sgarbossa, Paolo; Bertani, Roberta; Msaddek, Moncef; Journal of Organometallic Chemistry; vol. 819; (2016); p. 255 – 259;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

7650-91-1, Benzyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The selenides of the phosphines 1-8 were prepared by heating (60 C) each phosphine in CDCl3 (0.5 mL) with a three-fold excess of selenium in an NMR tube under nitrogen for 3 hours. Upon cooling to room temperature, the 31P{1H} NMR spectrum of each solution was recorded, and in each case revealed quantitative conversion to the corresponding phosphine selenide. The 31P{1H} NMR chemical shifts and 1JPSe coupling constants of the selenides are provided in Table 1., 7650-91-1

As the paragraph descriping shows that 7650-91-1 is playing an increasingly important role.

Reference£º
Article; Tassone, Joseph P.; Mawhinney, Robert C.; Spivak, Gregory J.; Journal of Organometallic Chemistry; vol. 776; (2015); p. 153 – 156;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13991-08-7, 1,2-Bis(diphenylphosphino)benzene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of CuCl (19.6mg, 0.2mmol) and dppb (89.3mg, 0.2mmol) with an excess of batho (66.5mg, 0.2mmol) were dissolved in CH2Cl2 (5mL) and 17 CH3OH (5mL) solution, stirred at room temperature for 6h. The insoluble residues were removed by filtration, and the filtrate was evaporated slowly at room temperature to yield yellow crystalline products. Yield: 80%. Anal. Calc. for C54H40ClCuN2P2: C, 73.83; H, 4.59; N, 3.19. Found: C, 73.62; H, 4.73; N, 3.06%. IR (KBr disc, cm-1): 3652m, 3279w, 3049w, 1962w, 1614m, 1555m, 1514w, 1481m, 1433w, 1410w, 1384w, 1226m, 1095s, 1025w, 865s, 836m, 769s, 745s, 696vs, 663w, 628w, 529s, 484s. 1H NMR (600MHz, CDCl3, 298K) delta 8.39ppm (d, 2H), 8.06ppm (d, 2H), 7.74ppm (d, 2H), 7.69ppm (m, 4H), 7.63ppm (m, 10H), 7.41-7.31ppm (m, 20H); 1P NMR (400MHz, CDCl3, 298K) delta -2.62ppm.

13991-08-7, As the paragraph descriping shows that 13991-08-7 is playing an increasingly important role.

Reference£º
Article; Yu, Xiao; Fan, Weiwei; Wang, Guo; Lin, Sen; Li, Zhongfeng; Liu, Min; Yang, Yuping; Xin, Xiulan; Jin, Qionghua; Polyhedron; vol. 157; (2019); p. 301 – 309;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.657408-07-6,Dicyclohexyl(2′,6′-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine,as a common compound, the synthetic route is as follows.,657408-07-6

To an argon degassed and dried flask was added (2S,3S)-2-amino-N-(2-fluoro-4-iodo-phenyl)-3-phenyl-butyramide (796 mg, 1.99 mmol), zinc cyanide (352 mg, 2.99 mmol), tetrakis-triphenylphosphine palladium (0) (116 mg, 0.1 mmol) and dry tetrahydrofuran (4 mL). After heating at 80 C. for 8 hours there was no reaction. To the cooled mixture was added 2-dicylohexylphosphino-2′-6′-dimethoxybiphenyl (42 mg, 0.1 mmol) and the reaction mixture heated again to 80 C. for 90 minutes, again no reaction occurred. To the cooled mix was added triethylamine (840 mul, 5.99 mmol) and the reaction mixture heated at 80 C. for 2 hours, again no reaction occurred. To the cooled mix was added 2-dicylohexylphosphino-2′-6′-dimethoxybiphenyl (84 mg, 0.2 mmol) and still no reaction occurred after 2 hours at 85 C. To the cooled mix was added rac-2-2′-bis(diphenylphosphino)-1-1’binaphthyl (125.6 mg, 0.2 mmol) and dry toluene (2 mL). After heating at 85 C. for 40 hours the reaction mix was dissolved in ethyl acetate (50 mL) and washed with 1.5 N aqueous potassium hydrogen sulfate solution, saturated aqueous sodium bicarbonate solution and the aqueous layers were back extracted with ethyl acetate (2¡Á50 mL). The combined organic layers were dried over sodium sulfate and concentrated. The crude residue was purified by chromatography over silica gel gradient eluted from 5 to 15% v/v ethyl acetate in hexanes to give (2S,3S)-2-amino-N-(4-cyano-2-fluoro-phenyl)-3-phenyl-butyramide as a yellow residue after concentration of the product containing fractions (120 mg, 20.2% yield). HRMS: Obs Mass (M+H+), 531.2035. Calcd. Mass, 531.2038 for C29H28FN4O5+.

As the paragraph descriping shows that 657408-07-6 is playing an increasingly important role.

Reference£º
Patent; Niu, Huifeng; US2008/207563; (2008); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

50777-76-9, General procedure: A mixture of p-toluenesulfonic acid (10 mg), 2-(diphenylphosphino)benzaldehyde (282 mg, 0,974 mmol) and3-amino-2-(S)-1-hydroxyethyl)-3H-quinazolin-4-one(100 mg, 0,487 mmol) in ethanol (10 mL) and heated at120 ¡ãC for 12 h. The reaction was cooled and analyzed by TLC [ethylacetate:hexane/1:5]. The solvent was evaporatedunder reduced pressure until dryness and the residue wasdissolved in CH2Cl2.The solution was washed with NaHCO3followed by H2Oand the organic phase was dried withNa2SO4.The crude product, obtained by evaporation of thesolvent, was purified by chromatography on silica gel using1:9 ethylacetate:hexane as an eluent. Yield 101 mg (44percent),m.p.: 130?131 ¡ãC (dec.). 1H NMR (400.2 MHz, CDCl3):delta(ppm) 9.88 (d, 1H, JPH = 5.8 Hz, HC = N), 8.12 (m, 2H,ArCH), 7.52 (m, 2H, ArCH), 7.44?7.21 (m, 12H, ArCH),6.84 (m, 2H, ArCH), 4.84 (m, 1H, CH), 4.35 (s, OH), 1.34(d, 3H, J = 6.4 Hz, CH3).13C NMR (100.6 MHz, CDCl3):delta (ppm) 165.5 (d, JPC = 19.2 Hz, N = CH), 158.7?121.6(Ar), 65.4 (CH), 22.1 (CH3). 31P{1H} NMR (162.0 MHz,CDCl3):delta (ppm) ? 15.35 (s). FTIR (KBr, cm?1): 3451 (OH);1687 (C = O); 1607 (C = N); 1435 (P-Ph). Anal. calcd. forC29H24N3O2P:C, 72.95; H, 5.07; N, 8.80percent. Found: C, 73.33;H, 5.29; N, 8.47percent.

As the paragraph descriping shows that 50777-76-9 is playing an increasingly important role.

Reference£º
Article; Y?lmaz, Mustafa Kemal; Kele?, Mustafa; Transition Metal Chemistry; vol. 43; 3; (2018); p. 285 – 292;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6224-63-1, Tri-m-tolylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2mmol NaOH (0.080g) is dissolved in 10ml of methanol and 2mmol of carbon disulfide (CS2) (0.150g, 120mul, density=1.266g/ml) is then added. The clear solution is then added to a 10ml acetonitrile solution which contains 0.5mmol AgNO3 (0.085g) and 1mmol tri-aryl-phosphines (tpp: 0.262g (1), 0.304g, tptp and tmtp: 0.304g (2 and 3)). The mixture was stirred for 3h at 0¡ãC and the resulting yellow solution was filtered off. Colorless crystals of 1?3 suitable for X-ray analysis were grown from slow evaporation of the solution after 2days., 6224-63-1

As the paragraph descriping shows that 6224-63-1 is playing an increasingly important role.

Reference£º
Article; Banti, Christina N.; Kourkoumelis, Nikolaos; Tsiafoulis, Constantinos G.; Skoulika, Stavroula; Hadjikakou, Sotiris K.; Polyhedron; vol. 121; (2017); p. 115 – 122;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29949-84-6,Tris(3-methoxyphenyl)phosphine,as a common compound, the synthetic route is as follows.

EXAMPLE 81 7-(3-Methoxyphenyl)-1-(4-methylpiperazin-1-yl)naphthalene A mixture of 3-methoxy-1-bromobenzene (0.089 mL, 0.71 mmol), 7-trimethylstannyl-1-(4-methylpiperazin-1-yl)naphthalene (0.25 g, 0.64 mmol), bis(acetonitrile) palladium chloride (0.0085 g, 0.032 mmol), tri(3-methoxyphenyl)phosphine (0.023 g, 0.064 mmol), and butylated hydroxytoluene (BHT, about 0.001 g, antioxidant) in dimethyl formamide (12 mL) was warned to 110 C. for 2 hours. The reaction was cooled to room temperature and diluted with 1N aqueous lithium chloride (25 mL) and 1 N sodium hydroxide (2 mL); then extracted with ether (3X). The combined ether layer was washed with 1N aqueous lithium chloride and brine. The organic phase was dried over calcium sulfate and concentrated. The residue was purified by flash chromatography on silica gel (1*2.5 inches). Elution proceeded as follows: 75% ethyl acetate/hexane, 200 mL, nil; 2% methanol/ethyl acetate 200 mL and 10% methanol/ethyl acetate, 200 mL, 0.084 g of an oil. This oil was further purified by kugelrohr distillation (1 mm Hg). The distillation proceeded as follows: 110-130 C., 0.014 g of a mixture of the title product and 7-methyl-1-(4-methylpiperazin-1-yl)naphthalene: 200-220 C., 0.062 g (23%) of the title compound as a yellow oil: 1 H NMR delta 8.43 (incompletely resolved dd, J=1.2Hz, 1 h), 7.90 (d, J=9 Hz, 1 H), 7.74 (dd, J=2, 8.5 Hz, 1 H), 7.58 (d, J=8 Hz, 1 H), 7.43 (sym m, 2 H), 7.34 (dt, J=1.5, 7.5 Hz, 1 H), 7.29 (5, J=2 Hz, 1 H), 7.14 (dd, J=1, 7.5 Hz, 1 H), 6.96 (ddd, J=1,2.5, 8 Hz, 1H), 3.92 (s, 3 H) 3.20 (br s, 4 H), 2.75 (br s, 4 H), 2.44 (s, 3 H). The product was dissolved in chloroform and HCl gas was bubbled through the solution to form the hydrochloride salt. Concentration of this solution to about 1 mL. at the boil and addition of about 1 mL of ether caused the white crystalline product to precipitate. The hydrochloride salt weighted 0.057 g: mp 236-238 C. Analysis calculated for C22 H24 N2 O*HCl: C, 71.63; H, 6.83; N, 7.59. Found: C, 71.31; H, 6.92; N, 7.59.

29949-84-6, 29949-84-6 Tris(3-methoxyphenyl)phosphine 141534, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Pfizer Inc.; US5597826; (1997); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

1608-26-0, N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of the aminobenzamidine 1 (5.0 mmol) and tris (dimthylamino) phosphine (5.0 mmol) dissolved in anhydrous toluene (10 mL) were heated under reflux for 48 h. After evaporating the solvent in vacuum, the resulting solid product was recrystallized from CCl4 (2b, 2d) or alternatively the obtained oil (2a, 2c) was purified by column chromatography using silica gel (60-120 mesh) with ethyl acetate: petroleum ether (4 : 6) as eluant., 1608-26-0

The synthetic route of 1608-26-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Hichri, Sarra; Abderrahim, Raoudha; Letters in Organic Chemistry; vol. 13; 4; (2016); p. 289 – 292;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1070663-78-3,Dicyclohexyl(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine,as a common compound, the synthetic route is as follows.

1070663-78-3, [(i3-indenyl)Pd(.i-OTf)j2 (0.10 g, 0.135 mmol) and BrettPhos (0.145 g, 0.270 mmol) were added to a 20 mL vial equipped with a flea stir bar. THF (10 mL) was added to the vialand a red homogenous mixture was observed. The mixture was stirred for one hour at room temperature, at which time the solvent was removed under reduced pressure. The red oil was titrated with pentane to yield a dark red solid. Yield: 0.220 g, 90%. 1H NMR (CDCl3, 500 MHz): 7.44 (s, 1H), 7.16-6.93 (m, 7H), 6.82 (d, J = 6.5 Hz, 1H), 6.63 (s, 1H), 6.06 (s, 1H), 4.17 (d, 5.4 Hz, 1H), 3.92 (s, 3H), 3.33 (s, 3H), 3.15 (sept, J = 5.6 Hz, 1H), 2.79 (q, J = 5.7Hz, 1H), 2.56 (q, J = 5.7 Hz, 1H), 2.27-1.67 (m, 16H), 1.54-0.81 (m, 20H), 0.69 (d, J = 6.1Hz, 3H), 0.45 (d, J = 6.2 Hz, 3H) ppm. 13C{1H} NMR (126 MHz, CDCl3): 154.85, 154.17,153.51, 151.21, 151.08, 150.96, 139.93, 139.89, 135.74, 135.33, 134.74, 134.58, 129.16,127.13, 125.74, 125.47, 124.60, 122.89, 122.59, 120.93, 119.38, 116.60, 116.43, 115.46,114.21, 114.16, 112.88, 112.84, 109.62, 109.58, 70.76, 67.95, 56.04, 54.71, 39.16, 38.98,38.71, 38.51, 34.38, 34.19, 32.77, 32.21, 31.94, 30.53, 30.51, 30.30, 29.79, 29.24, 27.35,27.25, 27.09, 26.99, 26.87, 26.79, 26.75, 26.67, 26.42, 25.83, 24.93, 24.61, 24.31, 24.16,23.85 ppm. 31P{1H} NMR (CDCl3 100 MHz): 58.19 ppm. 19F NMR (471 MHz, CDCl3):-78.01 ppm.

As the paragraph descriping shows that 1070663-78-3 is playing an increasingly important role.

Reference£º
Patent; YALE UNIVERSITY; HAZARI, Nilay; MELVIN, Patrick; (59 pag.)WO2018/183328; (2018); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.18437-78-0,Tris(4-fluorophenyl)phosphine,as a common compound, the synthetic route is as follows.

General procedure: Complex 1a (24 mg, 0.03 mmol) and appropriate triarylphosphine(0.06 mmol) were suspended in 5ml of acetone, andthe reaction mixture was ultrasonicated for 2 h. The resulting suspensionwas evaporate to dryness and the dry residue was chromatographedon Silica (eluent dichloromethane: methanol = 4: 1)to afford yellow-orange solid of 2a-d.

18437-78-0, As the paragraph descriping shows that 18437-78-0 is playing an increasingly important role.

Reference£º
Article; Zhukovsky, Daniil D.; Sizov, Vladimir V.; Starova, Galina L.; Tunik, Sergey P.; Grachova, Elena V.; Journal of Organometallic Chemistry; vol. 867; (2018); p. 367 – 374;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate