Day: November 3, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.607-01-2,Ethyldiphenylphosphine,as a common compound, the synthetic route is as follows.

Under nitrogen gas protection, 344 mg of Fe2S2(CO)6 (1 mmol) and 20 mL of tetrahydrofuran solvent were added to a flask equipped with a stirrer magnet.A dark red solution was obtained and the resulting solution was cooled down to -80C in a liquid nitrogen bath.2.2 mL of lithium triethylborohydride (1M in THF) was added slowly with stirring.After 15 minutes of reaction, 0.2 mL of trifluoroacetic acid was added and the reaction was continued for 10 minutes.Add 0.2 mL of formaldehyde solution (37%wt) and raise the reaction to room temperature.After stirring the reaction for 2 h, 235 mg of Ph2PCH2CH3 (1.1 mmol) was added.After stirring for 11h at room temperature, the tetrahydrofuran solvent was removed by rotary evaporation.Add 20 mL of methylene chloride and 1 mL of concentrated sulfuric acid and continue stirring for 20 h.20 mL of water was added and the layers were separated. The dichloromethane in the organic layer was removed by rotary evaporation.The residue was extracted with methylene chloride, and then thin layer chromatography was performed using a developing solvent having a methylene chloride/petroleum ether volume ratio of 1:3. The main red band was collected to obtain a model 3 with a yield of 24%.

607-01-2, As the paragraph descriping shows that 607-01-2 is playing an increasingly important role.

Reference£º
Patent; Sichuan University of Science and Engineering; Li Yulong; Zou Like; Mu Chao; Deng Chenglong; Wu Yu; Zhao Peihua; Xie Bin; Luo Qiang; (10 pag.)CN106674288; (2017); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

166330-10-5, (Oxybis(2,1-phenylene))bis(diphenylphosphine) is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Synthesis of the phosphine oxidesThe phosphine oxides were synthesized by oxidation ofthe corresponding phosphines. Calculated amounts of H2O2(30percent) were added slowly to the vigorously stirred THF solutionof the respective phosphine. Stirring was maintainedat room temperature for 2 h. After evaporation of THF, theresidue was treated with acetone-ethyl acetate to obtain therespective phosphine oxide product as a precipitate. The precipitatesthus obtained were filtered off and dried in a vacuum.All melting points were above 360 C with decomposition. DPEPO: 1H NMR (250 MHz, CDCl3): d = 7:75 ? 7:64(m, 9H, Phen-H), 7.42 (m, 13H, Phen-H), 7.05 ? 7.04 (t, 2H,Phen-H), 7.07 (t, 2H, Phen-H), 7.08 (t, 2H, Phen-H). ? MS(EI): m=z = 570. Yield 84percent., 166330-10-5

The synthetic route of 166330-10-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Pietraszkiewicz, Marek; Mal, Suraj; Pietraszkiewicz, Oksana; Gorski, Krzysztof; Chelwani, Nitin; Zeitschrift fur Naturforschung, B: Chemical Sciences; vol. 69; 2; (2014); p. 239 – 247;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

855-38-9, Tris(4-methoxyphenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,855-38-9

General procedure: To a solution of [Fe2(CO)6{mu-SCH(CH3)CH(CH3)S}] (0.040 g, 0.10 mmol) and tris(4-fluorophenyl)phosphine (0.032 g, 0.10 mmol) in CH2Cl2 (5 mL) was added a solution of Me3NO¡¤2H2O (0.011 g, 0.10 mmol) in MeCN (5 mL). The mixture was stirred at room temperature for 1 h, and then the solvent was reduced on a rotary evaporator. The residue was subjected to TLC using CH2Cl2/petroleum ether = 2:5 (v/v) as eluent.

855-38-9 Tris(4-methoxyphenyl)phosphine 70071, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Lin, Hui-Min; Wang, Ling-Hui; Liu, Xu-Feng; Liu, Xing-Hai; Jiang, Zhong-Qing; Transition Metal Chemistry; vol. 45; 1; (2020); p. 47 – 53;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1608-26-0,N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine,as a common compound, the synthetic route is as follows.

General procedure: A mixture of 0.8 g of the substrate 1a (4.8 mmol) and 9a(5.2 mmol) in 20 cm3 THF was heated at the reflux temperature for 6 h (TLC), and the excess of the volatile materials was removed under vacuum. The precipitate was collected and washed several times with CH2Cl2 to give the1:1 dipolar adduct 10a. Compound 10a (1.33 g, 85% yield) was pure enough for carrying out the spectroscopic analyses and stable for few days at -10 C. When 10a was quenched with acetic acid containing a catalytic amount of polyphosphoric acid (PPA), and the reaction mixture was heated at 110 C for 2 h (TLC), 2-oxothiazaphosphinane-2-methylamidate (11a) was obtained (0.81 g, 64% yield). 2-Oxothiazaphosphinane-2-ethylamidate (11b) was also obtained (0.91 g, 67% yield) when 1a was allowed to reactwith 9b, using the same conditions and stoichiometric quantities, and was used directly for the second step without separation or identification. 4-Oxo-1(2-[tris(dimethylamino)phosphonio]propyl)-1,4-dihydropyrimidine-2-thiolate (10a, C13H26N5OPS)Yellow substance; m.p.: 177 C (EtOH); 1H NMR(500 MHz, CDCl3): d = 2.83 (d, 3JPH = 9.8 Hz, 18H,[(Me)2N]3P), 1.18 (ddt (m), 3H, MeCP), 4.52-4.60 (m, 2H,H2CN), 5.88, 6.94 (2d, JHH = 7.4 Hz, 2 9 1H, HC5,HC6), 7.32-7.38 (m, 1H, HCP) ppm; 13C NMR (125 MHz,CDCl3): d = 169.9 (C=O), 160.8 (C=N), 135.4 (d,4JPC = 3.8 Hz, C6), 94.9 (C5), 51.4 (d, 2JPC = 12.8 Hz,MeCP), 36.9 (d, 2JPC = 13.7 Hz, [(Me2)N]3P), 22.6 (d,1JPC = 133.2 Hz, CP), 13.6 (d, 2JPC = 11.6 Hz, MeCP)ppm; 31P NMR (200.7 MHz, DMSO-d6): d = 45.7 ppm;IR (KBr): v = 1685 (C=O), 1480 (S-enolic), 1322, 862(PNMe) cm-1; MS (70 eV): m/z (%) = 331 (M+, 54)., 1608-26-0

The synthetic route of 1608-26-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Abdou, Wafaa M.; Kamel, Azza A.; Shaddy, Abeer A.; Monatshefte fur Chemie; vol. 148; 12; (2017); p. 2195 – 2210;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

4020-99-9, Methoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In 1000 ml by adding reaction bottle 99.5g (0.46mol) diphenyl methoxy phosphorus (? 99.5% purity) and 87.4g (0.51mol) (content ? 99.2%) making between, under stirring condition temperature to 55 C, and at this temperature thermal insulation 10 hours, and cooled to the end of the 10 C, directly enters the reaction of the next., 4020-99-9

As the paragraph descriping shows that 4020-99-9 is playing an increasingly important role.

Reference£º
Patent; Suzhou Chenghe Medical Company Chemistry Limited Company; Xia, Qiujing; (6 pag.)CN105439828; (2016); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

1608-26-0, N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EMBODIMENT I (1R,cis)-2-[2-(2,2-dichlorovinyl)-3,3-dimethylcyclopropyl]ethanal dimethyl acetal Tri(dimethylamino)phosphine (168.3 mmol) was added over a period of 12 minutes to a stirred solution of carbon tetrachloride (167.4 mmol) in pentane (360 ml) kept at 0 C. under nitrogen in a 1-liter flask. Then, the mixture in the flask was stirred for 30 minutes at 0 C. This finished the first step. At 0 C. (1R,cis)-2-(2,2-dimethoxyethyl)-3,3-dimethylcyclopropanecarbaldehyde (66.4 mmol) was added dropwise to the suspension in the flask over a period of nine minutes. The temperature was increased to 12 C. over a period of 15 minutes and stirring was continued at the temperature for a further 15 minutes. This finished the second step. Then water (75 ml) was added at 12 C. and–after removal of the aqueous phase–the organic phase was washed with two 35-ml portions of water. The washed organic phase was dried over anhydrous magnesium sulphate and the solvent was evaporated from the dried solution to give a residue (17.4 g) containing the desired product (100% (1R,cis), purity 88%, yield 91.1%). The NMR spectrum of the desired product showed the following absorptions: delta=1.00 ppm singlet H3 C–C–CH3 delta=3.33 ppm singlet C–(O–CH3)2 delta=5.59 ppm doublet C=CH delta=1.13 ppm singlet H3 C–C–CH3 delta=4.33 ppm triplet (H3 C–O)2 –CH– multiplets for the two H atoms bound to the ring and for HC–CH2 –CH., 1608-26-0

The synthetic route of 1608-26-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Shell Oil Company; US4298757; (1981); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6372-42-5, Cyclohexyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,6372-42-5

General procedure: To a solution of 1 (0.2 mmol) in 2 mL of CH3CN/H2O(v/v = 100/1) was added Selectfluor (71 mg, 0.2 mmol). The mixture was stirred at room temperature for 5-60minutes. After removal of the solvent, the residue was then purified by flash column chromatography on silica gel with petroleum ether/ethyl acetate to give the desired product 2.

6372-42-5 Cyclohexyldiphenylphosphine 80756, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Chen, Qian; Zeng, Jiekun; Yan, Xinxing; Huang, Yulin; Du, Zhiyun; Zhang, Kun; Wen, Chunxiao; Tetrahedron Letters; vol. 57; 30; (2016); p. 3379 – 3381;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

7650-91-1, Benzyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7650-91-1, 1. “A”reaction. Benzyldiphenylphosphine (approximately 2.0 g or 13 mmol from Strem Chemicals, Inc. of Newburyport, Massachusetts (“Strem”) ) and platinum (II) chloride (approximately 1.8 g or 12 mmol ; Strem) can be combined in the presence of tetrabutylammonium chloride (approximately 330 mg or 0.12 mmol from Sigma-Aldrich Corp. of St. Louis, Missouri (“Aldrich”)) in chlorobenzene (approximately 100 mL; ALDRICH) and can be stirred at approximately 130 C for approximately 10 minutes under nitrogen, after which time the volatile components can be removed in vacuo. The solid residue may be suspended in methanol, and the resulting solid can be isolated via filtration, washed with ether, and allowed to dry in vacuo. The yield of this resulting solid can be approximately 3.5 g. 2. “B”reaction. The entire yield of the resulting solid from the A reaction can be combined with 2,2, 6,[6-TETRAMETHYL-3, 5-HEPTANEDIONE, sodium salt (approximately 1.8 g or 8.7 mmol that can be prepared from the corresponding acid and sodium hydride (both from ALDRICH)) and 2- ethoxyethanol (approximately 50 mL; ALDRICH). The contents may be stirred under nitrogen at approximately 120 C for approximately 45 minutes. The volatile components can then be removed in vacuo. The desired product can be purified from a resulting crude dark brown solid via silica gel flash chromatography with hexanes/ethyl acetate (at a ratio of approximately 20: 1) as the eluting solvent (product Rf = 0.7). The desired product (approximately 250 mg or 0.38 mmol, 3.2% from PtCI2) can be isolated as a colorless foamy solid that exhibits blue luminescence under 254 and 365 nm illumination. 1H NMR (300 MHz, CD2CI2, 296 K): 7.76-7. 83 (4H, m), 7.38-7. 46 (4H, m), 7.13-7. 25 (2H, m), 6.90-7. 13 (3H, m), 5.86 (1H, s), 3.71 (2H, d, J = 11.6 Hz), 1.29 (9H, s), 1.09 (9H, s) ppm.

As the paragraph descriping shows that 7650-91-1 is playing an increasingly important role.

Reference£º
Patent; E.I. du Pont de Nemours and Company; WO2004/16710; (2004); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

657408-07-6, Dicyclohexyl(2′,6′-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,657408-07-6

Step 2 To a 500 mL round flask was added 3-(2,6-dichlorophenyl)-6,7-dimethylimidazo[1,2-f]phenanthridine (2.4 g, 6.1 mmol), phenylboronic acid (3.74 g, 30 mmol), Pd2(dba)3 (1.1 g, 1.2 mmol), 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl (S-Phos, 1.97 g, 4.8 mmol), potassium phosphate tribasic (7.64 g, 36 mmol), and 100 mL of toluene. The reaction was heated to reflux and stirred under a nitrogen atmosphere for 12 hours. After cooling, the mixture was purified by a silica gel column. Yield of 3-(2,6-diphenylphenyl)-6,7-dimethylimidazo[1,2-f]phenanthridine was 0.9 g.

657408-07-6 Dicyclohexyl(2′,6′-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine 11269872, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Universal Display Corporation; EP2243785; (2010); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

50777-76-9, 2-(Diphenylphosphino)benzaldehyde is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The iminophosphine ligands were prepared according to the method reported by Shirakawa and co-workers [70]. To 2-(diphenylphosphino)enzaldehyde(1) (200 mg, 0.689 mmol) 0.758 mmol (1.1 M equivalent) of the corresponding amine and 10 mL of freshly distilled toluene were added. The mixture was stirred under reflux (150?160 ¡ãC oil bath temperature) for 6 h.The solvent was removed in vacuo and the crude product was purified by bulb-to-bulb vacuum distillation (170 ¡ãC at 0.05 mm Hg,consistently used for all products) using a Kugel Rohr apparatus into which argon was continuously piped to prevent the ingress of oxygen. Since the iminophosphine products were unstable onsilica, no Rf-values are included for the iminophosphine ligands., 50777-76-9

Big data shows that 50777-76-9 is playing an increasingly important role.

Reference£º
Article; Traut-Johnstone, Telisha; Kanyanda, Stonard; Kriel, Frederik H.; Viljoen, Tanya; Kotze, P.D. Riekert; Van Zyl, Werner E.; Coates, Judy; Rees, D. Jasper G.; Meyer, Mervin; Hewer, Raymond; Williams, D. Bradley G.; Journal of Inorganic Biochemistry; vol. 145; (2015); p. 108 – 120;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate