With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1079-66-9,Chlorodiphenylphosphine,as a common compound, the synthetic route is as follows.
Under nitrogen protection,1L three bottles,From 29.3 g of 2-bromotoluene,5 g of magnesium turnings and 400 mlOf anhydrous methyl tetrahydrofuran to produce a Grignard reagent,Refluxed for 6 hours,To the room temperature, 2 g of tetrakis (triphenylphosphine) palladium was added,Stirred for 10 minutes,40 g of diphenylphosphonium chloride was added dropwise at room temperature,The reaction was refluxed for 6 hours.To the reaction solution was added dropwise 200 mL of an ice-water bathThe saturated aqueous ammonium chloride solution was quenched,Liquid separation,The organic phase is dissolved,Add methanol crystallization,Filtration gave 45 g of white 2-diphenylphosphine toluene,Yield 95%.
1079-66-9, The synthetic route of 1079-66-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Panjin Gelin Kaimo Technology Co., Ltd.; Rao, Zhihua; Gong, Ningrui; (12 pag.)CN105859774; (2016); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate