With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.719-80-2,Ethoxydiphenylphosphine,as a common compound, the synthetic route is as follows.
General procedure: Equimolar mixture of chloride 2a and respective phosphite or phosphinite 3 in benzene was kept at room temperature for 12 h. Solvent was evaporated in vacuo, solid residue was triturated with petroleum ether. In case of reaction of 2a with phosphinite 3c the precipitated phosphine oxide 4c was separated by filtration and washed with benzene. 4.5.3. [1-(Benzyloxycarbonylamino)-2,2,3,3-tetrafluoropropyl](dipheny)phosphine oxide 4c. Yield 59%; mp 177-179 C. 1H NMR (CDCl3): delta = 4.96 (d, 1H, 2JHH = 12 Hz, PhCHA), 5.03 (d, 1H, 2JHH = 12 Hz, PhCHB), 5.34 (m, 1H, CHP), 5.53 (d, 1H, 3JHH = 10 Hz, NH), 6.27 (tt, 1H, 2JHF = 54, 3JHF = 5 Hz, HCF2), 7.2-7.9 (m, 15H, Ph) ppm. 19F NMR (CDCl3): delta = -120.4 (m, 1F, CFAFB), -120.6 (m, 1F, CFAFB), -139.2 (d, 1F, 2JFH = 54 Hz, HCFAFB), -139.5 (d, 1F, 2JFH = 54 Hz, HCFAFB) ppm. 31P NMR (CDCl3): delta = 29.1 ppm. 13? NMR (CDCl3) (selected signals): delta = 51.81 (dt, 1JCP = 74, 2JCF = 24 Hz, CHP), 66.50 (CH2), 109.43 (dt, 1JCF = 252, 2JCF = 30 Hz, HCF2), 156.34 (C=O) ppm. Anal. calcd for C23H20F4NO3P: C, 59.36; H, 4.33; N, 3.01. Found: C, 59.67; H, 4.43; N, 3.17., 719-80-2
As the paragraph descriping shows that 719-80-2 is playing an increasingly important role.
Reference£º
Article; Onys’ko, Petro P.; Zamulko, Kateryna A.; Kyselyova, Olena I.; Yelenich, Ivanna P.; Rassukana, Yuliya V.; Journal of Fluorine Chemistry; vol. 185; (2016); p. 191 – 196;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate