Day: November 2, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.224311-51-7,2-(Di-tert-Butylphosphino)biphenyl,as a common compound, the synthetic route is as follows.

Example 123A 4-(5-Bromo-pyridin-3-yl)-piperazine-1-carboxylic Acid Tert-Butyl Ester A solution of the 3,5-dibromo-pyridine (12.8 g, 68.8 mmol) and piperazine-1-carboxylic acid tert butyl ester (10 g, 42.4 mmol) in 200 mL of dioxane was treated with Pd2(dba)3 (5 g, 5.5 mmol), 2-(di-tbutyl-phosphino)biphenyl (4 g, 13.4 mmol), and sodium t-butoxide (7.2 g, 75 mmol). The reaction was heated to 95¡ã C. for 8 h then cooled and filtered through celite. The mixture was evaporated and the residue was purified by flash column chromatography on silica gel, eluding with a solvent gradient of 1:4 ethyl acetate/hexane to 100percent ethyl acetate. Recovered 2.9 g of product (20percent). MS (ESI) m/z 344 (M+H)+., 224311-51-7

224311-51-7 2-(Di-tert-Butylphosphino)biphenyl 2734215, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Li, Qun; Woods, Keith W.; Zhu, Gui-Dong; Fischer, John P.; Gong, Jianchun; Li, Tongmei; Gandhi, Virajkumar; Thomas, Sheela A.; Packard, Garrick K.; Song, Xiaohong; Abrams, Jason N.; Diebold, Robert; Dinges, Jurgen; Hutchins, Charles; Stoll, Vincent S.; Rosenberg, Saul H.; Giranda, Vincent L.; US2003/187026; (2003); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

166330-10-5, (Oxybis(2,1-phenylene))bis(diphenylphosphine) is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a Schlenk flask containing Cu(CH3CN)4*BF4 (0.032g,0.1 mmol) and DPEphos (0.054g, 0.1 mmol) was added CH2Cl2 (10 mL) under nitrogen atmosphere, and the solution (i) was stirred at room temperature (RT) for 4 h. A CH2Cl2 (10 mL) and CH3OH (10 mL) mixture solution of NHPIP (0.034 g, 0.1 mmol) and KOH (0.006 g, 0.1 mmol) was also stirred at room temperature (RT) for 4 h to give solution (ii). Then, (ii) was added into (i) by a syringe under nitrogen. After reaction of 48 h at RT, the solution was filtered and the solventwas removed by a rotary evaporator. The residue was dissolved in diethyl ether, and orange block crystals were obtained by the solvent evaporation method (0.080 g, 85percent). IR (nu, cm?1, Figure S1 (Supporting Information)): 3374 m, 2929 s, 2851 m, 1740 w, 1701 w, 1651 w, 1590 s, 1542 w, 1511 m, 1461 m, 1436 s, 1384 m, 1331 s, 1260 w, 1216 w, 1102 m, 1170 w, 1029 w, 859 w, 805 w, 734 m, 696 m. 1H NMR (400 MHz, [D6]DMSO, Figure S2): delta 8.94 (d, J = 8.1Hz, 2H), 8.58 (d, J = 8.5 Hz, 4H), 8.28 (d, J = 8.5 Hz, 2H), 7.66 (dd, J = 7.8, 4.7 Hz, 2H), 7.44 (t, J = 7.8 Hz, 2H), 7.31?7.22 (m, 6H), 7.18 (t, J = 7.4 Hz, 8H), 7.08 (t, J = 7.5Hz, 2H), 6.97 (d, J = 5.4 Hz, 8H), 6.62 (s, 2H). Anal. Calcd. for C55H38CuN5O3P2: C, 70.10; H, 4.06; N, 7.43percent. Found: C,71.2; H, 4.35; N, 7.62percent., 166330-10-5

166330-10-5 (Oxybis(2,1-phenylene))bis(diphenylphosphine) 4285986, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Liu, Xin Fang; Zhang, Xiao Yu; Li, Rong Fang; Feng, Xun; Bulletin of the Korean Chemical Society; vol. 37; 3; (2016); p. 282 – 286;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

719-80-2, Ethoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

719-80-2, Preparation Example 206,7,8-Trifluoro-4-thiophenyl-3 (diphenylphosphorylmethyl)-quinoline (B13); A solution of G13 (5.2 g, 13.4 mmol) and ethyl diphenylphosphinite (6.2 ml, 27 mmol) in toluene (25 ml) was refluxed for 2 h during which time the precipitated solid developed. After cooling to room temperature, the solid was isolated by filtration and washed with toluene. The product was then dried to obtain the title compound (6.6 g, 96.9% yield), mp: 244-245 C.

719-80-2 Ethoxydiphenylphosphine 69754, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY; US2011/46379; (2011); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

18437-78-0, Tris(4-fluorophenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To 20 mL methanolic suspension of palladium(II) chloride (0.177 g,1 mmol) in a round bottom three-neck flask was added tris(4-fluorophenyl)phosphine (0.316 g, 1 mmol) solution in acetone (20 mL) and sodium 4-(3-methoxyphenyl)piperazine-1-carbodithioate (0.290 g, 1 mmol) solution in methanol (30 mL) in a dropwise manner.The reaction mixture was refluxed for 6 h with constant stirring. The formed greenish precipitate was separated by filtration (scheme 1). This precipitate was re-dissolved in acetone, and on slow evaporation, needle crystals were obtained.Yield: (0.470 g, 60percent), m.p. 250 ¡ãC. Mol. Wt: 745.48: Anal. Calcd C30H27ClF3N2OPPdS2: C, 49.62 (49.65); H, 3.72 (3.68); N, 3.86 (3.80); S, 8.82 (8.79): IR(4000?200 cm?1): 1584 nu(C?N); 1002 nu(CSSsym); 250 nu(Pd?S); 338 nu(Pd?Cl); 218 nu(Pd?P):1H NMR (CDCl3,300 MHz) delta (ppm): 3.81 (s, 3H, H10), 3.89 (t, 4H, H3, H3?, 3J1H,1H = 4.8 Hz), 4.06 (t, 4H, H2, H2?, 3J1H,1H = 5.1 Hz), 6.44 (s, 1H, H5), 6.45 (d, 1H, H9,3J1H,1H = 2.4 Hz), 6.52 (dd, 1H, H8, 3J1H,1H = 2.4, 2.7 Hz), 6.54 (d, 1H, H7, 3J1H,1H = 2.4 Hz), 7.14?7.73 (m, 12H, H12, H12?, H13, H13?). 13C NMR (CDCl3, 75 MHz) delta (ppm): 46.5 (C3, C3?), 48.9 (C2, C2?), 55.3 (C10), 103.6 (C5), 105.9 (C7), 109.6 (C9),116.0 (C12), 125.3 (C13), 130.2 (C8), 151.4 (C4), 160.7 (C6), 163.2 (C11), 165.7 (C14),206.2 (C1). 31P NMR (121.49 MHz, CDCl3) delta (ppm): 24.36.

18437-78-0, As the paragraph descriping shows that 18437-78-0 is playing an increasingly important role.

Reference£º
Article; Khan, Shahan Zeb; Amir, Muhammad Kashif; Naseer, Muhammad Moazzam; Abbasi, Rashda; Mazhar, Kehkashan; Tahir, Muhammad Nawaz; Awan, Iqra Zubair; Zia-Ur-Rehman; Journal of Coordination Chemistry; vol. 68; 14; (2015); p. 2539 – 2551;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6737-42-4, 1,3-Bis(diphenylphosphino)propane is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6737-42-4, Accurate weighing1,3-bis(diphenylphosphino)propane (0.1237 g, 0.3 mmol), potassium acetate (0.1325 g,1.35 mmol) was added to a 25 mL Schlenk reaction flask followed by 2-methylbromobenzene (128 muL, 0.9 mmol), solventIt was dimethyl sulfoxide (2 mL) and reacted at 60 C for 24 h. After completion of the reaction, it was extracted with ethyl acetate/water and dried over anhydrous sodium sulfate.The organic phase was removed under reduced pressure. EtOAc (EtOAc/EtOAc)80%.

6737-42-4 1,3-Bis(diphenylphosphino)propane 81219, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Dalian University of Technology; Yu Xiaoqiang; Bao Ming; Feng Xiujuan; Yin Qing; (15 pag.)CN109970789; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

1608-26-0, N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a well-stirred solution of compounds (2a-2b) (2mmol) in anhydrous toluene (15 mL) was added hexamethylphosphoroustriamide (2mmol). The mixture was heated under reflux for 12 h. Silica gel TLC indicated the completion of the reaction. The solvent was evaporated under reduced pressure, and the residue was purified on silica gel preparative TLC using ethyl acetate as eluent. A mixture of compounds (3a-3b) (1mmol), S8 (5 mmol) and anhydrous toluene (10mL) was refluxed for 4h, and then cooled. The sulfur excess was filtered off, and the solvent was removed under reduced pressure. Flash column chromatography on silica gelusing petroleum ether as eluant affords (4a-4b)., 1608-26-0

As the paragraph descriping shows that 1608-26-0 is playing an increasingly important role.

Reference£º
Article; Balti, Monaem; Efrit, Mohamed Lotfi; Journal of Sulfur Chemistry; vol. 37; 4; (2016); p. 466 – 475;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

719-80-2, Ethoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

719-80-2, General procedure: 2-Chloromethylbenzothiazole (1) (0.183 g, 0.001 mol) andpotassium iodide (KI) (0.166 g, 0.001 mol) were taken intoa round bottomed flask containing 20 mL of THF. Thereaction mixture was stirred for 3 h at 40C. After completionof the reaction as checked by TLC, cooled the reactionmass to RT and then filtered to remove the salt (KCl),resulted in iodo compound, 2-(iodomethyl) benzo[d]thiazole(2). The filtrate was transferred into a flask and sodiumazide (NaN3) (0.065 g, 0.001 mol) was added. The reactionmixture was stirred at 25-30C for 3 h to form an intermediate,2-azidomethylbenzothiazole (3). The reaction mixturewas filtered to remove the salt, NaI, and filtrate was takenfor the next step.Triphenylphosphine (4a) (0.262 g, 0.001mol) was added to 3under N2 atmosphere. The reaction mixture was stirred at 65-70C for 4 h and the progress of the reaction was monitored byTLC using ethylacetate: n-hexane (2:3) as an eluent. After completionof the reaction, the solvent was removed from the reactionmixture in a rotaevaporator to get the crude product and itwas purified by column chromatography using ethylacetate:nhexane(1:4) to obtain pure product, N-(1,3-Benzothiazol-2-ylmethyl)-N-(1,1,1-triphenyl-lambda5-phosphanylidene) amine (5a).The same procedure was adopted for the synthesis of remainingtitle compounds and the physical data of these compounds aresummarized in Table 1.

719-80-2 Ethoxydiphenylphosphine 69754, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Madhava; Subramanyam; Thaslim Basha; Jawahar Babu; Naga Raju; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 191; 1; (2016); p. 16 – 21;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.719-80-2,Ethoxydiphenylphosphine,as a common compound, the synthetic route is as follows.

General procedure: Equimolar mixture of chloride 2a and respective phosphite or phosphinite 3 in benzene was kept at room temperature for 12 h. Solvent was evaporated in vacuo, solid residue was triturated with petroleum ether. In case of reaction of 2a with phosphinite 3c the precipitated phosphine oxide 4c was separated by filtration and washed with benzene. 4.5.3. [1-(Benzyloxycarbonylamino)-2,2,3,3-tetrafluoropropyl](dipheny)phosphine oxide 4c. Yield 59%; mp 177-179 C. 1H NMR (CDCl3): delta = 4.96 (d, 1H, 2JHH = 12 Hz, PhCHA), 5.03 (d, 1H, 2JHH = 12 Hz, PhCHB), 5.34 (m, 1H, CHP), 5.53 (d, 1H, 3JHH = 10 Hz, NH), 6.27 (tt, 1H, 2JHF = 54, 3JHF = 5 Hz, HCF2), 7.2-7.9 (m, 15H, Ph) ppm. 19F NMR (CDCl3): delta = -120.4 (m, 1F, CFAFB), -120.6 (m, 1F, CFAFB), -139.2 (d, 1F, 2JFH = 54 Hz, HCFAFB), -139.5 (d, 1F, 2JFH = 54 Hz, HCFAFB) ppm. 31P NMR (CDCl3): delta = 29.1 ppm. 13? NMR (CDCl3) (selected signals): delta = 51.81 (dt, 1JCP = 74, 2JCF = 24 Hz, CHP), 66.50 (CH2), 109.43 (dt, 1JCF = 252, 2JCF = 30 Hz, HCF2), 156.34 (C=O) ppm. Anal. calcd for C23H20F4NO3P: C, 59.36; H, 4.33; N, 3.01. Found: C, 59.67; H, 4.43; N, 3.17., 719-80-2

As the paragraph descriping shows that 719-80-2 is playing an increasingly important role.

Reference£º
Article; Onys’ko, Petro P.; Zamulko, Kateryna A.; Kyselyova, Olena I.; Yelenich, Ivanna P.; Rassukana, Yuliya V.; Journal of Fluorine Chemistry; vol. 185; (2016); p. 191 – 196;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1079-66-9,Chlorodiphenylphosphine,as a common compound, the synthetic route is as follows.

Under nitrogen protection,1L three bottles,From 29.3 g of 2-bromotoluene,5 g of magnesium turnings and 400 mlOf anhydrous methyl tetrahydrofuran to produce a Grignard reagent,Refluxed for 6 hours,To the room temperature, 2 g of tetrakis (triphenylphosphine) palladium was added,Stirred for 10 minutes,40 g of diphenylphosphonium chloride was added dropwise at room temperature,The reaction was refluxed for 6 hours.To the reaction solution was added dropwise 200 mL of an ice-water bathThe saturated aqueous ammonium chloride solution was quenched,Liquid separation,The organic phase is dissolved,Add methanol crystallization,Filtration gave 45 g of white 2-diphenylphosphine toluene,Yield 95%.

1079-66-9, The synthetic route of 1079-66-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Panjin Gelin Kaimo Technology Co., Ltd.; Rao, Zhihua; Gong, Ningrui; (12 pag.)CN105859774; (2016); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

12150-46-8, 1,1-Bis(diphenylphosphino)ferrocene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A benzene solution (20mL) of 1 (100mg, 0.148mmol) and dppf (82mg, 0.148mmol) was refluxed for 45min. The solvent was removed under reduced pressure and the residue was chromatographed by TLC on silica gel. Elution with n-hexane/CH2Cl2 (3:1 v/v) developed two bands. The faster moving band gave a very dark solid, tentatively assigned as [Fe3(CO)9(mu3-Te)2(kappa1-dppfO)] (15mg, 9percent), and the second band afforded [Fe3(CO)8 (mu3-Te)2 (kappa2-dppf)] (6) (60mg, 35percent) as red crystals after recrystallization from hexane/CH2Cl2 at 4¡ãC. Characterization data for [Fe3(CO)8(mu3-Te)2(kappa1-dppfO)]: IR (nu(CO), CH2Cl2): 2053s, 2039vs, 2010vs, 1996 vs, 1964s cm?1. 1H NMR (CDCl3): delta 8.23?7.43 (m, 20H), 4.4?4.38 (m, 4H), 3.35?3.31 (m, 4H). 31P{1H} NMR (CDCl3): delta 51.0 (s), 28.0 (s). Characterization data for 6: IR (nu(CO), CH2Cl2): 2039s, 1998vs, 1963s, 1951mcm?1. 1H NMR (CDCl3): delta 7.60?7.43 (m, 8H), 7.4?7.43 (m, 12H), 4.47 (s, 4H), 4.38 (s, 4H). 31P{1H} NMR (CDCl3): delta 51.2 (s). ESI-MS: m/z 1145.47 (M+, calc. 1145.35).

12150-46-8, The synthetic route of 12150-46-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Rahaman, Ahibur; Lisensky, George C.; Tocher, Derek A.; Richmond, Michael G.; Hogarth, Graeme; Nordlander, Ebbe; Journal of Organometallic Chemistry; vol. 867; (2018); p. 381 – 390;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate