Day: October 30, 2020

50777-76-9, 2-(Diphenylphosphino)benzaldehyde is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

50777-76-9, Fluorene (16.62 g, 0.1 mol) was added to a solution of (3.9 g, 0.17 mol) sodium in 200-mL ethanol, the mixture was kept at 60 ¡ãC then a solution of (29 g, 0.1 mol) 2-diphenylphosphino benzaldehyde in 40-mLethanol was added dropwise. The mixture turned red after 2 h then the reaction was cooled and the solids were crystallized from dichloromethane?hexane. Yield: 85percent, m.p.:153 ¡ãC.

As the paragraph descriping shows that 50777-76-9 is playing an increasingly important role.

Reference£º
Article; Nemati Kharat, Ali; Rajabi Kouchi, Fereshteh; Tamaddoni Jahromi, Bahareh; Journal of Coordination Chemistry; vol. 69; 1; (2016); p. 12 – 19;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13991-08-7, 1,2-Bis(diphenylphosphino)benzene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

42.5 mg mesityl -Cu and 3ml of Toluene were added to 46.3(0.23 mmol) of 7-TpIn and 103.7mg (0.23 mmol) of dppb in a glove box. It formsa yellow solution. It was dried in vacuum, dissolved in dichloromethane and coatedwith a layer of hexane. It forms yellow crystals. Under UV (356nm), these emitlight in a strong yellow. Yield: 68%.

13991-08-7, The synthetic route of 13991-08-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK PATENTGMBH; WESEMANN, LARS; KLEIH, MATTHIAS; MAYER, HERMANN, AUGUST; (72 pag.)JP2016/501830; (2016); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

855-38-9, Tris(4-methoxyphenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,855-38-9

A mixture of 12-bromododecanoic acid (302 mg, 1.08 mmol) and tris(4-methoxyphenyl)phosphine (400 mg, 1.14 mmol) in degassed MeCN (5 mL) under N2 was heated at 80 00 for 3 d. On cooling the solvent was removed in vacuo and the resultingresidue purified by column chromatography eluting with 0-10% MeOH in DCM to give (11-carboxyundecyl)tris(4-methoxyphenyl)phosphonium bromide (545 mg, 80%) as a white solid.

As the paragraph descriping shows that 855-38-9 is playing an increasingly important role.

Reference£º
Patent; NOVINTUM BIOTECHNOLOGY GMBH; SPAREY, Tim; RATCLIFFE, Andrew; COCHRANE, Edward; STEVENSON, Brett; HALLETT, David; LAGASSE, Franz; LASSALLE, Gilbert; FROIDBISE, Alexandre; (106 pag.)WO2018/193113; (2018); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.12150-46-8,1,1-Bis(diphenylphosphino)ferrocene,as a common compound, the synthetic route is as follows.

The heteroleptic nickel, palladium and platinum complexes (1?10) were prepared according to the general procedure shown in Scheme 1. To a stirring 15 ml methanolic solution of the ligand K2(p-CH3C6H4SO2N=CS2)¡¤2H2O (0.18 g, 0.5 mmol), K2(p-ClC6H4SO2N=CS2)¡¤2H2O (0.19 g, 0.5 mmol), K2(p-BrC6H4SO2N=CS2)¡¤2H2O (0.21 g, 0.5 mmol) or K2C2H5OCO(CN)CCS2 (0.13 g, 0.5 mmol) a 10ml aqueous solution of NiCl2¡¤6H2O (0.12 g, 0.5 mmol), K2PdCl4 (0.163 g, 0.5 mmol) or K2PtCl4 (0.21 g, 0.5 mmol) was added and in each case the reaction mixture was stirred for half an hour to get a clear solution. To this 25 ml solution was added a 10 ml dichloromethane solution of 1,1?-bis(diphenylphosphino)ferrocene (0.28 g, 0.5 mmol) with vigorous stirring and then further stirred for 12 h in the case of Ni and 24 h for Pd and Pt complexes. The volume of the reaction mixtures were reduced to 15 ml on rotary evaporator and the solid products thus obtained were filtered off and washed with H2O?CH3OH (40:60 v/v) and dried in vacuo over calcium chloride.

12150-46-8, 12150-46-8 1,1-Bis(diphenylphosphino)ferrocene 51341936, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Singh, Santosh K.; Chauhan, Ratna; Diwan, Kiran; Drew, Michael G.B.; Bahadur, Lal; Singh, Nanhai; Journal of Organometallic Chemistry; vol. 745-746; (2013); p. 190 – 200;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13689-20-8, Cyclohexyldiphenylphosphine oxide is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Add cyclohexyldiphenylphosphine (28.4 mg, 0.1 mmol), copper triflate (3.6 mg, 0.01 mmol),Tetramethyldisilazane (26.7 mg, 0.2 mmol) and toluene (1 mL), the mixture was stirred at 80oC;TLC follows the reaction to completion;The crude product obtained after the reaction was recrystallized from toluene to obtain the target product (yield 82%). The analytical data of the product are as follows:, 13689-20-8

The synthetic route of 13689-20-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Soochow University (Suzhou); Zou Jianping; Li Chengkun; Yan Xuping; Wang Yijie; (14 pag.)CN110256489; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4020-99-9,Methoxydiphenylphosphine,as a common compound, the synthetic route is as follows.

In 1000 ml by adding reaction bottle 108g (0.5mol) diphenyl methoxy phosphorus (? 99.5% purity) and 86g (0.5mol) (content ? 99.2%) making between, to elevate temperature under stirring condition 50 C, and at this temperature thermal insulation 8 hours, and cooled to the end of the 10 C, directly enters the reaction of the next., 4020-99-9

The synthetic route of 4020-99-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Suzhou Chenghe Medical Company Chemistry Limited Company; Xia, Qiujing; (5 pag.)CN105418677; (2016); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

819867-21-5,819867-21-5, Di-tert-butyl(2′,6′-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

3-((1H-benzimidazol-1-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide Copper (I) iodide (396 mg, 4 mol.%) is added to a suspension of iododerivative (26.9 g, 52 mmol) and 1-ethynyl-1H-benzimidazole (7.4 g, 52 mmol) in a mixture of degassed dry triethylamine (100 ml) and degassed dry THF (40 ml) and the reaction mixture is stirred for 10 min. Pd(Ph3P)2Cl2 (730 mg, 2 mol.%), PPh3 (1.1 g) and di-tert-butyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine (100 mg) are then added, the reaction mixture is degassed twice and stirred at 65C for 80 h under inert atmosphere. Solvents are evaporated and the residue is purified chromatographically, using chloroform:methanol mixture of increasing polarity, yielding the desired product (13 g, 47%).

As the paragraph descriping shows that 819867-21-5 is playing an increasingly important role.

Reference£º
Patent; Obshchestvo S Ogranichennoy Otvetstvennostyou “Fusion Pharma”; CHILOV, Germes Grigorievich; TITOV, Ilya Yurievich; EP2743266; (2014); A2;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

50777-76-9,50777-76-9, 2-(Diphenylphosphino)benzaldehyde is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The iminophosphine ligands were prepared according to the method reported by Shirakawa and co-workers [70]. To 2-(diphenylphosphino)enzaldehyde(1) (200 mg, 0.689 mmol) 0.758 mmol (1.1 M equivalent) of the corresponding amine and 10 mL of freshly distilled toluene were added. The mixture was stirred under reflux (150?160 ¡ãC oil bath temperature) for 6 h.The solvent was removed in vacuo and the crude product was purified by bulb-to-bulb vacuum distillation (170 ¡ãC at 0.05 mm Hg,consistently used for all products) using a Kugel Rohr apparatus into which argon was continuously piped to prevent the ingress of oxygen. Since the iminophosphine products were unstable onsilica, no Rf-values are included for the iminophosphine ligands.

The synthetic route of 50777-76-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Traut-Johnstone, Telisha; Kanyanda, Stonard; Kriel, Frederik H.; Viljoen, Tanya; Kotze, P.D. Riekert; Van Zyl, Werner E.; Coates, Judy; Rees, D. Jasper G.; Meyer, Mervin; Hewer, Raymond; Williams, D. Bradley G.; Journal of Inorganic Biochemistry; vol. 145; (2015); p. 108 – 120;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.855-38-9,Tris(4-methoxyphenyl)phosphine,as a common compound, the synthetic route is as follows.,855-38-9

EXAMPLE 3 N-(4-Fluorophenyl)-6-[3-(trifluoromethyl)phenoxy]-pyridine-2-carboxamide 10.26 g (37.5 mmol) of 2-chloro-6-[3-(trifluoromethyl)phenoxy]pyridine (content: 99.5 percent, prepared according to Example 1), 6.25 g (56.2 mmol) of 4-fluoroaniline, 4.37 g (41.3 mmol) of sodium carbonate, 26.3 mg (37.5 mumol) of dichlorobis(triphenylphosphine)palladium(II) and 0.40 g (1.125 mmol) of tris(4-methoxyphenyl)phosphine (IV, R8 =R9 =R10 =methoxy) in 37.5 ml of xylene were placed in an autoclave at room temperature. The autoclave was flushed with inert gas, a carbon monoxide pressure of 5 bar was then applied and the mixture was heated to 150 C. The CO pressure was raised to 18 bar and the mixture was stirred for 21 hours at 150 C. After cooling to room temperature and depressurization, 50 ml of xylene and 50 ml of water were added to the reaction mixture, which was filtered. The aqueous phase was extracted with 25 ml of xylene and the combined organic phases were washed with 30 ml of water. Neither unconverted educt nor by-products were detectable by GC in the xylene phase. After distillation of the solvent, the crude product (15.83 g) was obtained in the form of a yellow solid.

As the paragraph descriping shows that 855-38-9 is playing an increasingly important role.

Reference£º
Patent; Lonza AG; US5900484; (1999); A;; ; Patent; Lonza AG; US5892032; (1999); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.224311-49-3,2′-(Di-tert-butylphosphino)-N,N-dimethyl-[1,1′-biphenyl]-2-amine,as a common compound, the synthetic route is as follows.

Bis[3-(1-naphthyl)-1H-inden-7-yl] ether Under an argon atmosphere, to a mixture of 5.50 g (15.6 mmol) of 4-bromo-1-(1-naphthyl)-2,3-dihydro-1H-inden-1-yl methyl ether, 4.00 g (15.5 mmol) of 3-(1-naphthyl)-1H-inden-7-ol, 6.60 g (31.1 mmol) of K3PO4, and 150 ml of toluene, a mixture of 183 mg (0.32 mmol) of Pd(dba)2 and 212 mg (0.62 mmol) of N-{2′-[di(tert-butyl)phosphino][1,1′-biphenyl]-2-yl}-N,N-dimethylamine was added. The resulting mixture was stirred for 8 hours at 100 C. Then, 300 ml of water was added, the organic layer was separated, and the aqueous layer was extracted with 3*75 ml of CH2Cl2. The combined extract was dried over Na2SO4 and evaporated to dryness. The crude 1-(1-methoxy-4-{[1-methoxy-1-(1-naphthyl)-2,3-dihydro-1H-inden-4-yl]oxy}-2,3-dihydro-1H-inden-1-yl)naphthalene was purified using a short colunm with Silica Gel 60 (40-63 mum, d 50 mm, 170 mm, eluant: CH2Cl2). This product was demethoxylated in a mixture of 170 ml of 16 M HCl and 170 ml of methanol for 7 hours at reflux. The crude product was extracted with 3*150 ml of CH2Cl2. The combined extract was washed with 2*100 ml of water, dried over K2CO3, and evaporated to dryness. The analytically pure product was obtained by flash chromatography on Silica Gel 60 (40-63 mum, d 35 mm, 1300 mm, eluant: hexanes-CH2Cl2=5:1). Yield, 2.65 g (34%) of a white solid., 224311-49-3

As the paragraph descriping shows that 224311-49-3 is playing an increasingly important role.

Reference£º
Patent; Voskoboynikov, Alexander Z.; Izmer, Vyatcheslav V.; Asachenko, Andrey F.; Nikulin, Mikhail V.; Ryabov, Alexey N.; Lebedev, Artyom Y.; Coker, Catalina L.; Canich, Jo Ann M.; US2007/135597; (2007); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate