With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.
To a solution of 6 (60 mg, 0.15 mmol) in dried and deoxygenated CH2Cl2 (5 mL) under agron atmosphere, were added CuSO4 (71.8 mg, 0.45 mmol) and diphenylphosphinobenzaldehyde 7 (48.6 mg, 0.17 mmol). After 7 hrs, the reaction mixture was filtered via canula and the solvent was evaporated. The mixture was purified by column chromatography Ethyl acetate: Hexanes: triethylamine (1 : 2: 0.02) affording 8 (100 mg, quant.) as a colorless oil. [alpha]D20: -32.7 (c 1.0, CHCl3). 1H NMR (500 MHz, CDCl3): delta = 8.58 (d, 1H, J = 3.8 Hz, NCHPh), 7.82-7.81 (m, 2H, arom), 7.63-7.17 (m, 22H, arom, triazol), 6.87-6.84 (m, 1H, arom), 5.64 (s, 1H, PhCHOO), 5.60 (d, 1H, J = 8.5 Hz, H-1), 4.38 (m, 1H, H-6), 4.13-4.04 (m, 2H, H-2, H-5), 3.89-3.85 (m, 2H, H-3,H-6)’, 3.80-3.74 (m, 1H, H-4). 13C-NMR (125 MHz, CDCl3): delta = 164.9, 164.8, 147.3, 138.7, 138.5, 138.4, 138.3, 137.7, 137.6, 136.9, 134.2 134.1, 133.7, 133.5, 130.6, 130.2, 129.3, 128.8, 128.7, 128.6, 128.5, 128.5, 128.4, 128.3, 126.3, 125.8, 119.7, 102.1, 87.2, 79.8, 72.4, 69.8, 68.3. 31P-NMR (121.4 MHz, CDCl3) : delta = 10.69 ppm. HMRS: Calcd for C40H36N4O4P [M]: 667.24770, found: 667.24770 (0.4 ppm)., 50777-76-9
Big data shows that 50777-76-9 is playing an increasingly important role.
Reference£º
Article; Khiar, Noureddine; Navas, Raquel; Ferna?ndez, Inmaculada; Tetrahedron Letters; vol. 53; 4; (2012); p. 395 – 398;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate