With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.18437-78-0,Tris(4-fluorophenyl)phosphine,as a common compound, the synthetic route is as follows.
A solution of (mu3-S)FeCo2(CO)9 (0.069 g, 0.15 mmol) and tris(4-fluorophenyl)phosphane(0.063 g, 0.2 mmol) in CH2Cl2 (10 mL) was added to a solution of Me3NO2H2O (0.022 g,0.2 mmol) and stirred at room temperature for 1 h. The solvent was reduced in vacuo andthe residue was subjected to TLC separation using CH2Cl2:petroleum ether = 1:5 (v/v) aseluent. From the first main brown band, 1 (0.039 g, 35percent) was obtained as a black solid. Fromthe second main brown band, 2 (0.040 g, 26percent) was obtained as a black solid. 1: IR (CH2Cl2,cm?1): nuC?O 2082 (vs), 2039 (vs), 2017 (vs), 1982 (s). 1H NMR (500 MHz, CDCl3): 7.427.38 (m,6H, PhH), 7.14 (t, J = 7.5 Hz, 6H, PhH) ppm. 31P{1H} NMR (200 MHz, CDCl3, 85percent H3PO4): 47.30 (s)ppm. 13C{1H} NMR (125 MHz, CDCl3): 164.22 (d, JP-F = 251.6 Hz, p-PhC), 135.31, 135.21 (dd,JP-C = 12.6 Hz, JP-F = 8.6 Hz, o-PhC), 129.83 (d, JP-C = 44.9 Hz, i-PhC), 116.28, 116.11 (dd,JP-C = 11.4 Hz, JP-F = 21.1 Hz, m-PhC) ppm. Anal. Calcd for C26H12Co2F3FeO8PS: C, 41.85; H, 1.62.Found: C, 41.77; H, 1.98percent. 2: IR (CH2Cl2, cm?1): nuC?O 2047 (s), 2013 (vs), 1984 (s). 1H NMR(500 MHz, CDCl3): 7.42, 7.11 (2s, 24H, PhH) ppm. 31P{1H} NMR (200 MHz, CDCl3, 85percent H3PO4):44.89 (s) ppm. Anal. Calcd for C43H24Co2F6FeO7P2S: C, 49.93; H, 2.34. Found: C, 49.81; H, 2.22percent., 18437-78-0
18437-78-0 Tris(4-fluorophenyl)phosphine 140387, achiral-phosphine-ligands compound, is more and more widely used in various fields.
Reference£º
Article; Zhao, Peng; Liu, Xu-Feng; Wu, Hong-Ke; Journal of Coordination Chemistry; vol. 70; 17; (2017); p. 3080 – 3094;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate