Day: October 29, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13991-08-7,1,2-Bis(diphenylphosphino)benzene,as a common compound, the synthetic route is as follows.

The experimental multi-tooth phosphine coordination silver complex double emitting dye synthesis method according to the following steps:1 mmol of multidentate phosphine ligand, 1 mmol of AgI, 5 ml of DCM were mixed and reacted at 40 C. for 10 hours. The mixture was spin-dried and purified by column chromatography with DCM and PE to obtain a multidentate phosphine coordination silver complex.Wherein the ratio of multidentate phosphine ligand to AgI is 1: 1.The volume ratio of DCM to PE in the mixed solvent of DCM and PE is 1:20.

13991-08-7, As the paragraph descriping shows that 13991-08-7 is playing an increasingly important role.

Reference£º
Patent; Heilongjiang University; Xu Hui; Zhang Jing; Han Chunmiao; (47 pag.)CN106833010; (2017); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

564483-19-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.564483-19-8,Di-tert-butyl(2′,4′,6′-triisopropyl-[1,1′-biphenyl]-2-yl)phosphine,as a common compound, the synthetic route is as follows.

General procedure: In a nitrogen-filled glovebox, phosphine ligand (0.21 mmol,1.00 eq.) and [(1,5-cyclooctadiene) Pd(CH2TMS)2] (80 mg,0.21 mmol, 1.00 eq.) were suspended in pentane (5.0 mL). The reaction mixture was stirred vigorously at room temperature, duringwhich time a solid precipitated from solution. After 48 h, thenon-homogenous mixture was filtered though a sintered glass frit.The filter cake was washed with pentane (10.0 mL) to yield thedesired complex. 9: Yellow-green solid (Yield: 106 mg, 79%). IR (neat): 2931,2850, 1580, 1456, 1419, 1376, 1359, 1293, 1252, 1170, 1155,1087, 1044, 1013, 929, 870, 851, 798, 746, 715 cm1.

The synthetic route of 564483-19-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Lee, Hong Geun; Milner, Phillip J.; Colvin, Michael T.; Andreas, Loren; Buchwald, Stephen L.; Inorganica Chimica Acta; vol. 422; (2014); p. 188 – 192;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13689-19-5,Tricyclohexylphosphine oxide,as a common compound, the synthetic route is as follows.

The same general procedure was adopted for the synthesis of all the complexes. The lanthanide chloride and tricyclohexylphosphine oxide were dissolved in hot ethanol. Heating was continued for 1h and the solution was allowed to slowly evaporate at room temperature during which time crystalline material formed. The crystals were filtered, washed with cold ethanol and dried at the pump.

13689-19-5, As the paragraph descriping shows that 13689-19-5 is playing an increasingly important role.

Reference£º
Article; Lees, Anthony M.J.; Platt, Andrew W.G.; Polyhedron; vol. 67; (2014); p. 368 – 372;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.564483-19-8,Di-tert-butyl(2′,4′,6′-triisopropyl-[1,1′-biphenyl]-2-yl)phosphine,as a common compound, the synthetic route is as follows.

564483-19-8, Example 16 3-(3-tert-Butyl-5-phenoxy-phenyl)-1H-pyridin-2-one (I-45) step 1-A mixture of 3-(3-bromo-5-tert-butyl-phenyl)-2-methoxy-pyridine (123 mg, 0.384 mmol), phenol (46 mg, 0.489 mmol), Pd(OAc)2 (4.1 mg, 0.018 mmol), 2-di-tert-butylphosphino-2′,4′,6′-tri-isopropyl-1,1′-biphenyl (9.9 mg, 0.023 mmol) and K3PO4 (167 0.787 mmol)) in a Schlenk flask was purged with argon before toluene (5 mL) was added. The reaction under an argon atmosphere was heated overnight at 115 C. The reaction was cooled to RT, filtered through CELITE, and the filtrate was concentrated. The crude residue was purified by SiO2 chromatography eluding with an EtOAc/hexane gradient (0 to 2% EtOAc) to afford 40 mg (41%) of 3-(3-tert-butyl-5-phenoxy-phenyl)-2-methoxy-pyridine (124). step 2-A solution of 124 (52 mg, 0.157 mmol), 48% HBr (50 L, 0.436 mmol) and HOAc (3 mL) in sealed tube was heated at 70 C. overnight. The reaction mixture was cooled to RT, carefully poured into a cold saturated aqueous NaHCO3 and then extracted with EtOAc. The organic layer was washed with brine, dried (Na2SO4), filtered and concentrated. The crude residue was purified on a preparative SiO2 TLC plate developed with 66% EtOAc/hexanes to afford 48 mg (96%) of I-45 as a foam.

As the paragraph descriping shows that 564483-19-8 is playing an increasingly important role.

Reference£º
Patent; Roche Palo Alto LLC; US2010/21423; (2010); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6224-63-1,Tri-m-tolylphosphine,as a common compound, the synthetic route is as follows.

General procedure: A solution of N,N,N’-trisubstitutedacyl thiourea (0.564mmol) and phosphine ligand (0.564mmol) in a minimal amount of methanol, was added drop wise to a solution of K2PdCl4 (0.564mmol) in 40mL of methanol at 50?60¡ãC. The resulting mixture was stirred for 3?4 h and the precipitated complexes (1?8) (Scheme 1 ) were filtered, and washed with methanol. Single crystal X-ray diffraction measurement quality crystals were obtained by slow evaporation of chloroform/methanol (3:1) solution of the complexes. The 1H and 13C NMR, FT-IR, the elemental analyses, melting point data for the complexes (1?8) are as follows:(7) (Tri(m-tolyl)phosphine-kappaP)(1-(2,4-dichlorobenzoyl)-3-(N-methylphenyl)thioureido-kappa2(O, S)palladium(II) chloride Quantities used were 0.184?g (0.564?mmol) K2PdCl4, 0.192?g (0.564?mmol) 1-(2,4-dichlorobenzoyl)-3-(N-methylphenyl)thiourea, 0.172?g (0.564?mmol) tri(m-tolyl)phosphine in methanol. Yield???80percent; Orange solid; m.p. 215-217?¡ãC. FTIR (cm-1); 3139(w), 2996(w), 2882(w), 1622(m), 1512(s), 1420(s), 1368(w), 1318(w), 1242(w), 1189(w), 1095(m), 1061(w), 1018(w), 988(w), 934(m), 910(s), 860(s), 784(s), 744(s), 692(s), 614(w). H NMR (300?MHz, CDCl3) delta 2.36 [(s, 9H, 3(-CH3)], 3.59 (s, 3H, N-CH3), 6.84-8.40 (m, 20H, ArH); 13C NMR (75.5?MHz, CDCl3) delta 21.6 (3C), 42.2 (C), 114.6 (C), 114.9 (C), 124.6 (C), 125.4 (C), 127.2 (2C), 127.5 (C),128.8 & 128.9 (d, 3C,13C-31P, 2J?=?12.0?Hz), 129.1(C), 129.3 (3C), 132.7 & 132.8 (d, 3C, 13C-31P, 3J?=?9.0?Hz), 134.7 & 134.9 (d, 3C, 13C-31P, 2J?=?11.5?Hz), 141.3 (3C), 151.1 (3C), 171.3 (1C, C=O), 173.9 (1C, C=S); 31P NMR (121.5?MHz, CDCl3) delta 32.87; Anal. Calc. for C36H32Cl3N2OPPdS (Mol. mass: 784.47) C, 55.12; H, 4.11; N, 3.57; S, 4.09. Found: C, 54.91; H, 3.99; N, 3.59; S, 4.03., 6224-63-1

As the paragraph descriping shows that 6224-63-1 is playing an increasingly important role.

Reference£º
Article; Khan, Muhammad Riaz; Zaib, Sumera; Khan, Azim; Badshah, Amin; Rauf, Muhammad Khawar; Imtiaz-ud-Din; Tahir, Muhammad Nawaz; Shahid, Muhammad; Iqbal, Jamshed; Inorganica Chimica Acta; vol. 479; (2018); p. 189 – 196;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.166330-10-5,(Oxybis(2,1-phenylene))bis(diphenylphosphine),as a common compound, the synthetic route is as follows.

2.679 g (8.635 mmol) of Rh(COD)(acac) was mixed with 20 ml of MEK in a 0.1 litre Schlenk flask. To the resulting slurry was added by syringe 1.22 ml of neat 54percent wt tetrafluoroboric acid in diethylether (8.74 mmol) by syringe over a period of 2 minutes, resulting in a red solution. After 5 minutes, 1.17 ml (9.66 mmol) of 1,5-cyclooctadiene was added by syringe. The brown red slurry was stirred for 20 minutes. Then 4.65 g (8.635 mmol) of DPEPhos was added in 2 portions over a period of 3 minutes. A orange slurry resulted after 5 minutes. The stirred slurry was reduced by evaporating MEK solvent until a slurry of the cationic complex in about 10 ml of residual solvent was obtained. To this slurry was added 20 ml of ethanol. The resulting orange slurry was degassed and stirred at room temperature for 1 hour before being filtered and washed with 2×5 ml of cold ethanol. After drying overnight (1 mbar, 2O0C), gave 7.26 g of complex [Rh cod DPEPhos] BF4 with approximately 0.75 equivalents of ethanol , Yield = 98.5 percent (8.51 mmol)., 166330-10-5

The synthetic route of 166330-10-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; JOHNSON MATTHEY PUBLIC LIMITED COMPANY; NEDDEN, Hans Guenter; WO2010/1173; (2010); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.18437-78-0,Tris(4-fluorophenyl)phosphine,as a common compound, the synthetic route is as follows.

A solution of (mu3-S)FeCo2(CO)9 (0.069 g, 0.15 mmol) and tris(4-fluorophenyl)phosphane(0.063 g, 0.2 mmol) in CH2Cl2 (10 mL) was added to a solution of Me3NO2H2O (0.022 g,0.2 mmol) and stirred at room temperature for 1 h. The solvent was reduced in vacuo andthe residue was subjected to TLC separation using CH2Cl2:petroleum ether = 1:5 (v/v) aseluent. From the first main brown band, 1 (0.039 g, 35percent) was obtained as a black solid. Fromthe second main brown band, 2 (0.040 g, 26percent) was obtained as a black solid. 1: IR (CH2Cl2,cm?1): nuC?O 2082 (vs), 2039 (vs), 2017 (vs), 1982 (s). 1H NMR (500 MHz, CDCl3): 7.427.38 (m,6H, PhH), 7.14 (t, J = 7.5 Hz, 6H, PhH) ppm. 31P{1H} NMR (200 MHz, CDCl3, 85percent H3PO4): 47.30 (s)ppm. 13C{1H} NMR (125 MHz, CDCl3): 164.22 (d, JP-F = 251.6 Hz, p-PhC), 135.31, 135.21 (dd,JP-C = 12.6 Hz, JP-F = 8.6 Hz, o-PhC), 129.83 (d, JP-C = 44.9 Hz, i-PhC), 116.28, 116.11 (dd,JP-C = 11.4 Hz, JP-F = 21.1 Hz, m-PhC) ppm. Anal. Calcd for C26H12Co2F3FeO8PS: C, 41.85; H, 1.62.Found: C, 41.77; H, 1.98percent. 2: IR (CH2Cl2, cm?1): nuC?O 2047 (s), 2013 (vs), 1984 (s). 1H NMR(500 MHz, CDCl3): 7.42, 7.11 (2s, 24H, PhH) ppm. 31P{1H} NMR (200 MHz, CDCl3, 85percent H3PO4):44.89 (s) ppm. Anal. Calcd for C43H24Co2F6FeO7P2S: C, 49.93; H, 2.34. Found: C, 49.81; H, 2.22percent., 18437-78-0

18437-78-0 Tris(4-fluorophenyl)phosphine 140387, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Zhao, Peng; Liu, Xu-Feng; Wu, Hong-Ke; Journal of Coordination Chemistry; vol. 70; 17; (2017); p. 3080 – 3094;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7650-91-1,Benzyldiphenylphosphine,as a common compound, the synthetic route is as follows.

The complex was obtained from benzyldiphenylphosphine in 54% yield by using a reported procedure [41]. M.p. 196-199C (dec.) [lit. [42] 198C (dec.)]. The 1H and 31P{1H} NMR data for the synthesized complex were consistent with the literature data [30]., 7650-91-1

The synthetic route of 7650-91-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Korte, Nicholas J.; Stepanova, Valeria A.; Smoliakova, Irina P.; Journal of Organometallic Chemistry; vol. 745-746; (2013); p. 356 – 362;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13991-08-7, 1,2-Bis(diphenylphosphino)benzene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Under argon atmosphere, 1,2-bis(diphenylphosphino)benzene (34.6 mg, 0.0776 mmol) was added to 5 mL of the solution of silver(I) tetrafluoroborate (15.1 mg, 0.0776 mmol) in dichloromethane, and the mixture was stirred at room temperature for 30 minutes. Then, 2,9-dichloro-1,10-phenanthroline (23.2 mg, 0.0931 mmol) was added to the reaction solution, which was heated to reflux with stirring for two hours. The reaction solution was filtrated, and the filtrate was concentrated, subjected to recrystallization by slow diffusion of dichloromethane-ether, and dried to provide 46.0 mg of the yellow solid complex. [Show Image] The NMR data of the obtained complex is provided below. 1H NMR (300 MHz, CDCl3) delta 8.80 (d, J = 8.1 Hz, 2H), 8.24 (s, 2H), 8.15 (d, J = 8.1 Hz, 2H), 7.62-7.51 (m, 4H), 7.39-7.29 (m, 20H); 31P NMR (122 MHz, CDCl3) delta -4.4 (d, J (31P-107Ag, 109Ag) = 325, 373 Hz). The composition of the obtained complex was determined according to the same method as in Example 15. The present complex corresponds to the above composition formula (5).

13991-08-7, As the paragraph descriping shows that 13991-08-7 is playing an increasingly important role.

Reference£º
Patent; Sumitomo Chemical Company, Limited; EP2360162; (2011); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

To a solution of 6 (60 mg, 0.15 mmol) in dried and deoxygenated CH2Cl2 (5 mL) under agron atmosphere, were added CuSO4 (71.8 mg, 0.45 mmol) and diphenylphosphinobenzaldehyde 7 (48.6 mg, 0.17 mmol). After 7 hrs, the reaction mixture was filtered via canula and the solvent was evaporated. The mixture was purified by column chromatography Ethyl acetate: Hexanes: triethylamine (1 : 2: 0.02) affording 8 (100 mg, quant.) as a colorless oil. [alpha]D20: -32.7 (c 1.0, CHCl3). 1H NMR (500 MHz, CDCl3): delta = 8.58 (d, 1H, J = 3.8 Hz, NCHPh), 7.82-7.81 (m, 2H, arom), 7.63-7.17 (m, 22H, arom, triazol), 6.87-6.84 (m, 1H, arom), 5.64 (s, 1H, PhCHOO), 5.60 (d, 1H, J = 8.5 Hz, H-1), 4.38 (m, 1H, H-6), 4.13-4.04 (m, 2H, H-2, H-5), 3.89-3.85 (m, 2H, H-3,H-6)’, 3.80-3.74 (m, 1H, H-4). 13C-NMR (125 MHz, CDCl3): delta = 164.9, 164.8, 147.3, 138.7, 138.5, 138.4, 138.3, 137.7, 137.6, 136.9, 134.2 134.1, 133.7, 133.5, 130.6, 130.2, 129.3, 128.8, 128.7, 128.6, 128.5, 128.5, 128.4, 128.3, 126.3, 125.8, 119.7, 102.1, 87.2, 79.8, 72.4, 69.8, 68.3. 31P-NMR (121.4 MHz, CDCl3) : delta = 10.69 ppm. HMRS: Calcd for C40H36N4O4P [M]: 667.24770, found: 667.24770 (0.4 ppm)., 50777-76-9

Big data shows that 50777-76-9 is playing an increasingly important role.

Reference£º
Article; Khiar, Noureddine; Navas, Raquel; Ferna?ndez, Inmaculada; Tetrahedron Letters; vol. 53; 4; (2012); p. 395 – 398;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate