With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1608-26-0,N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine,as a common compound, the synthetic route is as follows.
General procedure: A mixture of the aminobenzamidine 1 (5.0 mmol) andtris (dimthylamino) phosphine (5.0 mmol) dissolved in anhydroustoluene (10 mL) were heated under reflux for 48 h.After evaporating the solvent in vacuum, the resulting solidproduct was recrystallized from CCl4 (2b, 2d) or alternativelythe obtained oil (2a, 2c) was purified by columnchromatography using silica gel (60-120 mesh) with ethylacetate: petroleum ether (4 : 6) as eluant.
1608-26-0, 1608-26-0 N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine 15355, achiral-phosphine-ligands compound, is more and more widely used in various fields.
Reference£º
Article; Hichri, Sarra; Abderrahim, Raoudha; Letters in Organic Chemistry; vol. 13; 4; (2016); p. 289 – 292;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate