With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1070663-78-3,Dicyclohexyl(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine,as a common compound, the synthetic route is as follows.
1070663-78-3, EXAMPLE FORTY-FOUR: Synthesis of BrettPhosPdPhCl (18); In a nitrogen filled glovebox, a solution of BrettPhos (1, 51.0 mg, 96 mumol), chlorobenzene (100 muL) and THF (4 mL) was added to solid (COD)Pd(CH2SiPhMe2^ (40.8 mg, 80 mumol) in an oven-dried 20 mL vial. The vial was capped, and the resulting yellow solution was allowed to stand for 48 h at rt. After this time, pentane (14 mL) was layered on top of the THF solution and the vial was allowed to stand for 24 h resulting in the formation of crystals. After 24 h, the crystals were collected via vacuum filtration in the glovebox, and dried under vacuum to provide 18 (42 mg, 69%) as light-yellow microcrystalline powder: 1H NMR (400 MHz, CD2Cl2, mixture of rotomers) delta 7.28-7.30 (m, 2H – minor), 7.07-7.10 (m, 2H – minor), 7.04 (s, 2H – major), 7.02 (s, 2H – minor), 6.82-6.92 (m, major and minor), 6.76-6.82 (m, IH – minor, IH – major), 4.29 (s, 3H – minor), 3.79 (s, 3H -major), 3.59 (s, 3H – minor), 3.34 (s, 3H – major), 2.96-3.03 (m, IH – major), 2.88-2.95 (m, IH – major), 2.71-2.80 (m, 2H – major), 2.46-2.53 (m, 2H – major), 2.32-2.37 (m, 2H -minor), 1.50-1.90 (m, major and minor), 1.08-1.45 (m), 0.78-0.92 (m, major and minor), 0.55-0.65 (m, 2H – minor); 31P NMR (162 MHz, CD2Cl2, mixture of rotomers) delta 46.8 (minor), 38.6 (major). Anal CaIc for C4iH58C102PPd: C, 65.16; H, 7.74;. Found: C, 65.42; H, 7.53.
As the paragraph descriping shows that 1070663-78-3 is playing an increasingly important role.
Reference£º
Patent; MASSACHUSETTS INSTITUTE OF TECHNOLOGY; WO2009/76622; (2009); A2;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate