Day: October 23, 2020

18437-78-0, Tris(4-fluorophenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 1a (70.5 mg, 0.20 mmol), 4-phenylthioxanthone (3 mg, 0.01 mmol), CH3OH (30 mL) were added to a pyrex reaction flash which was equipped with a magnetic stirrer. The mixture was irradiated by a 23 W household lamp at rt under air atmosphere. The photoreaction was completed after 40 minutes as monitored by TLC (eluent: petroleum ether). The solvent was removed and the residue was purified by flash column chromatography on silica gel (eluent: petroleum ether/ethyl acetate = 10/1?EA) to afford 2a as a solid (74 mg, 100percent); 1H NMR (400 MHz, CDCl3) delta 7.56 (dd, J = 11.6, 8.8 Hz, 6 H), 6.95 (dd, J = 8.8, 2.0 Hz, 6 H), 3.83 (s, 9 H).

18437-78-0, The synthetic route of 18437-78-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ding, Aishun; Li, Shijie; Chen, Yang; Jin, Ruiwen; Ye, Cong; Hu, Jianhua; Guo, Hao; Tetrahedron Letters; vol. 59; 43; (2018); p. 3880 – 3883;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

4020-99-9, Methoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

trans-RuC12(slMes)(3-methyl-2-butenylidene)(Ph2P(OMe)), trans-C763: In an argon filled glove box, a 40 mL scintillation vial equipped with a magnetic stir bar was charged with C705 (2.000 g, 2.84 mmol) and dichloromethane (15 ml). To the stirring solution was added Phosphinite Ph2P(OMe) (0.556 mL, 2.84 mmol) in dichloromethane (5 mL). The reaction was stirred at room temperature for one hour then devolatilized. The resulting residue was recrystallized from dichloromethane/pentane at room temperature affording trans-C763 (1.35 g, 62.2%, >95% purity). ?H NMR (400 IVIFIz, CD2C12, ppm): oe18.37 (d, J= 11.2 Hz, 1H), 7.36-7.29 (m, 2H), 7.27 -7.15 (m, 8H), 7.06 -7.000 (m, 1H), 6.88 (s, 2H), 6.79 (s, 2H), 4.13 -3.87 (m,4H), 3.15 (d, J= 12.8 Hz, 3H), 2.56 (s, 6H), 2.37 (s, 6H), 2.32 (s, 3H), 2.24 (s, 3H), 1.10 (s, 3H),1.03 (s, 3H). 3?PNIVIR(161.8 IVIFIz, CD2C12, ppm): oe 134.4 (s)., 4020-99-9

4020-99-9 Methoxydiphenylphosphine 77636, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; MATERIA, INC.; GIARDELLO, Michael, A.; TRIMMER, Mark, S.; WANG, Li-Sheng; DUFFY, Noah, H.; JOHNS, Adam, M.; RODAK, Nicholas, J.; FIAMENGO, Bryan, A.; PHILLIPS, John, H.; (127 pag.)WO2017/53690; (2017); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13991-08-7, 1,2-Bis(diphenylphosphino)benzene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Under argon atmosphere, 20 mL of dry acetonitrile was added to silver(I) bromide (170 mg , 0.904 mmol) and 1,2-bis(diphenylphosphino)benzene (404 mg, 0.904 mmol), and the mixture was stirred at room temperature for one hour and then heated to reflux for seven hours. The reaction solution was allowed to reach room temperature, concentrated, and filtrated after being suspended in 9 mL of chloroform. The filtrated matter was subjected to thermal recrystallization from acetonitrile-chloroform and dried to obtain 399 mg of the colorless crystal complex. Under argon atmosphere, 3 mL of dry dichloromethane was added to the above obtained complex (80.0 mg, 0.0631 mmol) and triphenylphosphine (33.1 mg, 0.126 mmol), and the mixture was stirred at 40C for 10 minutes. The reaction solution was concentrated, subjected to recrystallization by slow diffusion of chloroform-ether, and dried to provide 108 mg of the complex. The result of elemental analysis for the obtained complex is shown in Table 2-2, and the composition ratio of the complex was obtained. The present complex corresponds to the above composition formula (3). The NMR data of the obtained complex is provided below. 1H NMR (300 MHz, CDCl3) delta 7.48-7.17 (m, 31H), 7.07-7.03 (m, 8H); 13C NMR (75 MHz, CDCl3) delta 134.8 (t, J = 2.4 Hz), 134.6-134.2 (m), 130.2-130.0 (m), 129.7 (br), 129.0 (br), 128.9 (br), 128.7-128.6 (m); 31P NMR (122 MHz, CDCl3) delta 8.1 (br, W1/2 = 87 Hz) , -14.8 (br, W1/2 = 340 Hz). The result of DART-MS measurement for the obtained complex is provided below. DART-MS (M/Z): found; 815.16. calcd; 815.13 (M-Br)+. Based on the DART-MS measurement of the obtained complex, it was confirmed that the obtained complex contained the following structure.

13991-08-7, The synthetic route of 13991-08-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sumitomo Chemical Company, Limited; EP2360162; (2011); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13689-19-5,Tricyclohexylphosphine oxide,as a common compound, the synthetic route is as follows.

Ce(NO3)4(Cy3PO)2 An excess of CAN (0.45 g 0.82 mmol) in2.5 mL water were stirred with a solution of Cy3PO (0.24 g0.81 mmol) in 1.8 mL of chloroform for 10 minutes. The orangechloroform layer was separated, dried (MgSO4), filtered and mixedwith an equal volume of diethylether. Cooling to -30 C gave yellowneedles suitable for X-ray crystallography (0.19 g 46% based onCy3PO). Analysis (%) Expected (found): C 44.08 (44.92) H6.78 (6.73)N 5.71 (5.69).

13689-19-5, 13689-19-5 Tricyclohexylphosphine oxide 26187, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Coles, Simon J.; Fieldhouse, Sarah J.; Klooster, Wim T.; Platt, Andrew W.G.; Polyhedron; vol. 161; (2019); p. 346 – 351;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17261-28-8,2-(Diphenylphosphino)benzoic acid,as a common compound, the synthetic route is as follows.

17261-28-8, The 1a? (439 mg, 1 mmol) was dissolved in CH2Cl2 (10 mL) and trifluoroacetic acid (1 ml) was dropwise added at 0 ¡ãC. Then the reaction mixture was stirred for 18 h at room temperature. All volatile compounds were removed in vacuo and the residue was dissolved in water and treated with the saturated Na2CO3 solution. The resulting mixture was extracted with CH2Cl2 (3x) and the combined organic layers were dried over Na2SO4. After filtration and then evaporation of the solvent, the crude free amine was obtained without purification for the next step. To the solution of the free amine in CH2Cl2 (8 ml) was added O-(benztriazol-1-yl)-N,N,N?,N?-tetramethyluronium hexafluorophosphate (HBTU, 417 mg, 1.1 mmol), followed by the addition of diisopropylethylamine (367 uL, 2.2 mmol) and 2-(diphenylphosphino)benzoic acid (306 mg, 1 mmol), The reaction mixture was then stirred for 6 h at room temperature. The mixture was combined with CH2Cl2 and water, and the organic layer was separated, washed with saturated sodium bicarbonate (2x), and dried overNa2SO4. The solvent was removed in vacuo to afford the crude product as a colourless oil, which was purified by flash chromatography (20percent EtOAc in hexanes) yielding the precat. 1a as a white solid (514 mg, 82percent). Mp. 93?95 ¡ãC [alpha]D30 = +20.8 (c 1.20, CH2Cl2); 1H NMR (400 MHz, CDCl3): delta = 7.63?7.61 (m, 2 H), 7.38?7.18 (m, 15 H), 7.12?6.98 (m, 8 H), 6.71 (d, J = 8.0 Hz, 1 H), 5.08 (dd, J = 11.2, 3.6 Hz, 1 H), 4.53 (dd, J = 8.4, 5.6 Hz, 1 H), 3.68 (d, J =11.2, 1 H), 2.12 (s, 6 H), 2.12?2.04 (m, 1 H), 0.84 (d, J = 7.2 Hz, 3 H), 0.82 (d, J = 7.2 Hz, 3H); 13C NMR (100 MHz, CDCl3): delta (C-P coupling not removed) = 171.1, 168.7, 141.2, 141.0, 140.5, 137.6, 137.5, 137.4, 136.6, 136.4, 134.5, 133.9, 133.8, 133.7, 132.1, 130.3, 129.7, 128.7, 128.6, 128.5, 128.5, 128.4, 127.9, 127.7, 127.7, 127.5, 127.5, 126.9, 73.2, 58.5, 54.8, 40.5, 31.8, 19.1, 18.0; 31P NMR (162 MHz, CDCl3) delta = ? 10.2; HRMS (ESI): calcd. for C40H43N3O2P [M+H]+ 628.3093, found 628.3095.

The synthetic route of 17261-28-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Zheng, Xiaojun; Deng, Qifu; Hou, Qinglin; Zhang, Kaiqiang; Wen, Pushan; Hu, Shunqin; Wang, Haifei; Synthesis; vol. 50; 12; (2018); p. 2347 – 2358;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13991-08-7,1,2-Bis(diphenylphosphino)benzene,as a common compound, the synthetic route is as follows.

General procedure: Synthesis of the phosphine oxidesThe phosphine oxides were synthesized by oxidation ofthe corresponding phosphines. Calculated amounts of H2O2(30%) were added slowly to the vigorously stirred THF solutionof the respective phosphine. Stirring was maintainedat room temperature for 2 h. After evaporation of THF, theresidue was treated with acetone-ethyl acetate to obtain therespective phosphine oxide product as a precipitate. The precipitatesthus obtained were filtered off and dried in a vacuum.All melting points were above 360 C with decomposition. OPPO: 1H NMR (250 MHz, CDCl3): d = 7:19 (m, 8H,Phen-H), 7.35 (m, 12H, Phen-H), 7.57 (t, 2H, Phen-H), 7.75(m, 2H, Phen-H). – MS (EI): m=z = 478. Yield 82%.

13991-08-7, As the paragraph descriping shows that 13991-08-7 is playing an increasingly important role.

Reference£º
Article; Pietraszkiewicz, Marek; Mal, Suraj; Pietraszkiewicz, Oksana; Gorski, Krzysztof; Chelwani, Nitin; Zeitschrift fur Naturforschung, B: Chemical Sciences; vol. 69; 2; (2014); p. 239 – 247;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1070663-78-3,Dicyclohexyl(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine,as a common compound, the synthetic route is as follows.

1070663-78-3, EXAMPLE FORTY-FOUR: Synthesis of BrettPhosPdPhCl (18); In a nitrogen filled glovebox, a solution of BrettPhos (1, 51.0 mg, 96 mumol), chlorobenzene (100 muL) and THF (4 mL) was added to solid (COD)Pd(CH2SiPhMe2^ (40.8 mg, 80 mumol) in an oven-dried 20 mL vial. The vial was capped, and the resulting yellow solution was allowed to stand for 48 h at rt. After this time, pentane (14 mL) was layered on top of the THF solution and the vial was allowed to stand for 24 h resulting in the formation of crystals. After 24 h, the crystals were collected via vacuum filtration in the glovebox, and dried under vacuum to provide 18 (42 mg, 69%) as light-yellow microcrystalline powder: 1H NMR (400 MHz, CD2Cl2, mixture of rotomers) delta 7.28-7.30 (m, 2H – minor), 7.07-7.10 (m, 2H – minor), 7.04 (s, 2H – major), 7.02 (s, 2H – minor), 6.82-6.92 (m, major and minor), 6.76-6.82 (m, IH – minor, IH – major), 4.29 (s, 3H – minor), 3.79 (s, 3H -major), 3.59 (s, 3H – minor), 3.34 (s, 3H – major), 2.96-3.03 (m, IH – major), 2.88-2.95 (m, IH – major), 2.71-2.80 (m, 2H – major), 2.46-2.53 (m, 2H – major), 2.32-2.37 (m, 2H -minor), 1.50-1.90 (m, major and minor), 1.08-1.45 (m), 0.78-0.92 (m, major and minor), 0.55-0.65 (m, 2H – minor); 31P NMR (162 MHz, CD2Cl2, mixture of rotomers) delta 46.8 (minor), 38.6 (major). Anal CaIc for C4iH58C102PPd: C, 65.16; H, 7.74;. Found: C, 65.42; H, 7.53.

As the paragraph descriping shows that 1070663-78-3 is playing an increasingly important role.

Reference£º
Patent; MASSACHUSETTS INSTITUTE OF TECHNOLOGY; WO2009/76622; (2009); A2;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6372-42-5,Cyclohexyldiphenylphosphine,as a common compound, the synthetic route is as follows.,6372-42-5

158.6 g (332.8 mmol in terms of sulfur trioxide) of fuming sulfuric acid containing 16.8% by mass of sulfur trioxide was placed in a 3-neck flask having an internal capacity of 300 mL, equipped with a thermometer, a stirring device, a dropping funnel, and a nitrogen gas line, and 35.03 g (130.54 mmol) of diphenylcyclohexylphosphine (hereinafter referred to as DPCHxP) was introduced thereinto for 1 hour. Further, the liquid temperature was controlled to a range of 25 C. to 30 C. After completion of the addition, the reaction was carried out at 50 C. for 7 hours. (0225) While controlling the liquid temperature to a range of 25 C. to 30 C., the reaction solution was diluted with 480 g of ion exchange water, and then transferred to a separatory funnel, and 250 g of toluene and 60 g of triisooctylamine were added thereto, followed by thoroughly mixing, thereby acquiring an organic phase. The organic phase was separated by adding 330 g of an aqueous 5%-by-mass sodium hydroxide solution to the organic phase. A lower phase was acquired and 76 g of an aqueous 20%-by-mass sulfuric acid solution was added dropwise thereto. Then, 70 g of toluene and 70 g of tetrahydrofuran were added thereto, followed by sufficiently mixing, thereby acquiring an organic phase. To the organic phase was added 15.85 g (156.63 mmol) of triethylamine, followed by stirring in the range of 20 C. to 30 C. for 1 hour. This liquid was concentrated until the liquid amount reached 50 g in the range of 35 C. to 70 C. and 4 kPa to 55 kPa. A precipitate formed by stirring this concentrated solution at 10 C. for 1 hour was collected by filtration through natural filtering, thereby acquiring 5.68 g of a white solid. (0226) 31P-NMR (400 MHz, 305 K, DMSO-d6, phosphoric acid, ppm) delta: a (3-sulfonatophenyl)phenylcyclohexylphosphine triethylammonium salt as a mono-form showed a peak at -4.49 and an oxide formed by oxidation of the phosphorous atoms showed a peak at 32.76. (0227) The acquisition was a mixture including 5.32 g (11.83 mmol, 93.81% by mole) of a (3-sulfonatophenyl)phenylcyclohexylphosphine triethylammonium salt and 0.36 g (0.78 mmol, 6.19% by mole) of an oxide formed by oxidation of the phosphorous atoms. From the viewpoint that 5.68 g (12.61 mmol in terms of phosphorous atoms) of a desired product could be acquired using 35.03 g (130.54 mmol) of DPCHxP, the yield based on phosphorous atoms was 9.7%. This phosphorous compound was referred to as a ligand L.

6372-42-5 Cyclohexyldiphenylphosphine 80756, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; KURARAY CO., LTD.; YOSHIKAWA, Tatsuya; TSUJI, Tomoaki; (30 pag.)US2016/46549; (2016); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.719-80-2,Ethoxydiphenylphosphine,as a common compound, the synthetic route is as follows.

719-80-2, 2.06 grams (7.84 mmol) of 2-(4-fluoro-3-methyl-phenyl)-4,6-dimethylbenzyl chloride was treated with ethyldiphenylphosphinite (2.08 grams, 9.01 mmol) and heated to 150 C. for 3 hrs. After cooling to room temperature, the crude mixture was purified by silicagel chromatography ((10% acetone/90% methylene chloride) and the appropriate fractions concentrated and recrystallized from ether/hexane to provide the title compound (MP 109-111 C.).

719-80-2 Ethoxydiphenylphosphine 69754, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Merck & Co., Inc.; US5969017; (1999); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.166330-10-5,(Oxybis(2,1-phenylene))bis(diphenylphosphine),as a common compound, the synthetic route is as follows.

A solution of the ligand DPEphos (0.355g, 0.66 mmol) in30 mL of dichloromethane was added drop by drop to a solution of CoCl2.6H2O (0.166g, 0.70 mmol) in 50 mL dichloromethane. The reaction mixture was refluxed under nitrogen for 1 h. After cooling the reaction mixture, the solvent was evaporated and the resultant solid mass was washed several times with ether and hexane. Finally, after drying under vacuum,a blue compound was obtained which was re-crystallized from dichloromethane. Yield: 90percent. Anal. Calcd. forC36H28Cl2OP2Co (percent): C, 64.69; H, 4.22, Co, 8.82; Found: C,64.12; H, 4.19; Co, 8.78; Selected peak assignments in MSESIm/z (percent): 1360 (5), [2M+Na]+; 1301 (30), [2M-Cl]+; 746(20), [M+2K]2+; 690 (30) [M+Na]+; 539 (50), [DPEphos]+;Selected IR frequencies (cm-1, KBr): 3051, 2985 (C-H);1485, 1435 (C=C); 1101 (C-O-C); 506 (Co-P); 336, 322 (Co-Cl) ); UV-Vis (CH2Cl2), max (nm): 246, 647, 713., 166330-10-5

As the paragraph descriping shows that 166330-10-5 is playing an increasingly important role.

Reference£º
Article; Sahu, Debojeet; Banik, Biplab; Borah, Malabika; Das, Pankaj; Letters in Organic Chemistry; vol. 11; 9; (2014); p. 671 – 676;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate