5518-52-5, Tri(furan-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
5518-52-5, A solution of 10-bromomethyl-10-desmethyl- erythralosamine N-oxide (4) (0.196 g, 0.310 mmol) in NMP (3 ml) was degassed and tris (2-furyl) phosphine (0.018 g, 0.077 mmol) and PD2DBA3. CHC13 (0.010 G, 0.010 mmol) added. The reaction mixture was heated at 50 C for 10 min and more tris (2-furyl) phosphine (0.12 ml, 0.372 mmol) added. The reaction mixture was heated at 80C for 22 h. The product was extracted with ethyl acetate, the organic phase washed with aqueous sodium hydrogen carbonate, brine and dried (MGSOG). The NMP was removed under reduced pressure and the residual material subjected to flash chromatography on silica gel using CH2C12 : MEOH : NH3 90: 4: 1, yield 0.096 g (51%) of a white crystalline solid. HRMS: [M+1] 606.3654. Calc. for C33HS1NO9 : 606.3636.
As the paragraph descriping shows that 5518-52-5 is playing an increasingly important role.
Reference£º
Patent; ALPHARMA APS; COCKBAIN, Julian; WO2004/56843; (2004); A2;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate