Day: October 22, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1608-26-0,N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine,as a common compound, the synthetic route is as follows.

General procedure: A solution of methyl iodide (1.14 g, 8 mmol) was added dropwise for 1 min to the stirringmixture of tertiary phosphine (4 mmol) in anhydrous tetrahydrofuran (16 mL) at roomtemperature. After the mixture was stirred at room temperature for 12 h, the mixture wasevaporated in vacuo. The residue was washed with ether, and the precipitate was dried invacuo for 12 h at 40 C to give corresponding quaternary phosphonium iodide as a whitepowder.

1608-26-0, As the paragraph descriping shows that 1608-26-0 is playing an increasingly important role.

Reference£º
Article; Aoyagi, Naoto; Furusho, Yoshio; Endo, Takeshi; Tetrahedron Letters; vol. 54; 51; (2013); p. 7031 – 7034;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

4020-99-9, Methoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

trans-RuC12(slMes)(CHPh)(Ph2P(OMe)), trans-C785: trans-C727 (4.35 g, 6.0 mmol) was dissolved in degassed CH2C12 (50 mL) with a magnetic stir bar under nitrogen in a round-bottomed flask. The flask was capped with a gas adaptor. Methyl diphenylphosphinite (2.6 g, 12 mmol) was syringed to the flask under nitrogen flow. The green solution turned brown immediately, which was continued to stir at room temperature for lh. The lights were removed under high vacuum, yielding a mixture of black oil and brown crystalline material. The flask was chilled by liquid nitrogen and the resulting solid was broken into small pieces with a spatula. Hexanes (50 mL) was added and the solvent was reduced by a rotary evaporator. The pink solid was collected by a frit funnel with vacuum filtration and washed with hexanes twice (2 x 25 mL). The solid was dried under high vacuum for 16h. Yield: 2.91g (62%). ?H NIVIR (400 IVIHz, C6D6, ppm): oe 19.33 (s, 1H, Ru=CH), 7.86 (d, J = 8 Hz, 2H), 7.33 (m, 4H), 7.13 (t, J = 8 Hz, 1H), 7.10 – 6.88 (m, 6H), 6.83 (s, 2H), 6.80 (m, 2H), 6.32 (s, 2H), 3.46 – 3.38 (m, 2H), 3.34 – 3.25 (m, 2H),3.29 (d, J = 12Hz, 3H), 2.79 (s, 6H), 2.39 (s, 6H), 2.17 (s, 3H), 1.90 (s, 3H). 3?P NIVIR (162 IVIHz, C6D6, ppm): oe 132.5 (s).

4020-99-9, 4020-99-9 Methoxydiphenylphosphine 77636, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; MATERIA, INC.; GIARDELLO, Michael, A.; TRIMMER, Mark, S.; WANG, Li-Sheng; DUFFY, Noah, H.; JOHNS, Adam, M.; RODAK, Nicholas, J.; FIAMENGO, Bryan, A.; PHILLIPS, John, H.; (127 pag.)WO2017/53690; (2017); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6372-42-5,Cyclohexyldiphenylphosphine,as a common compound, the synthetic route is as follows.,6372-42-5

General procedure: To a solution of [Fe2(CO)6{mu-SCH2CH(CH2O2CCH3)S}] (0.044?g, 0.1?mmol) and tris(2-furyl)phosphine (0.023?g, 0.1?mmol) in CH2Cl2 (5?mL) was added a solution of Me3NO¡¤2H2O (0.011?g, 0.1?mmol) in MeCN (5?mL). The mixture was stirred at room temperature for 1?h and then the solvent was reduced on a rotary evaporator. The residue was subjected to TLC separation using CH2Cl2/petroleum ether?=?1:1 (v/v) as eluent. From the main red band, 0.062?g (95%) of complex 2 was obtained as a red solid.

As the paragraph descriping shows that 6372-42-5 is playing an increasingly important role.

Reference£º
Article; Chen, Fei-Yan; He, Jiao; Mu, Chao; Liu, Xu-Feng; Li, Yu-Long; Jiang, Zhong-Qing; Wu, Hong-Ke; Polyhedron; vol. 160; (2019); p. 74 – 82;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

4020-99-9, Methoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

cis-RuC12(slMes)(phenylindenylidene)(Ph2P(OMe)), cis-C885: trans-C748? 2Py (27.18 g, 30 mmol) was placed in a round-bottomed flask with a magnetic stir bar under nitrogen, to which degassed heptanes were added (5000 mL). Phosphinite Ph2P(OMe) (6.8 g, 31.5 mmol) was added via syringe. The reaction vessel was evacuated and refilled with N2 (3x). The mixture was stirred under N2 for 1 hr at ambient temperature (20 – 25 C). because there was some undissolved starting material, degassed CH2C12 (250 mL) was added and all solids were dissolved. The solution was passed through a silica plug (2.5? x 1.5?, D X H) and CH2C12 was used as eluent to remove the first red band of material, which was trans-C885. Then EtOAc was used as eluent to remove a second band that was concentrated and filtered providing brown crystals of cis-C885 (8.49 g). ?H NMR (400 MHz, CD2C12, ppm): oe 8.78 (dd, J = 8 Hz, J = 1 Hz, 1H), 7.52-7.24 (m, 8H), 7.13 – 6.89 (m, 9H), 6.75 (m, 2H), 6.43 (s, 1H), 6.40 (s, 1H), 6.24 (s, 1H), 6.11 (s, 1H), 3.98-3.63 (m, 4H), 3.66 (d, J = 10 Hz, 3H), 2.79 (s, 3H), 2.56 (s, 3H), 2.54 (s, 3H), 2.21 (s, 3H), 1.95 (s, 3H),1.66 (s, 3H). 3?P NIVIR (161.8 MHz, CD2C12, ppm): oe 133.3 (s), 4020-99-9

As the paragraph descriping shows that 4020-99-9 is playing an increasingly important role.

Reference£º
Patent; MATERIA, INC.; GIARDELLO, Michael, A.; TRIMMER, Mark, S.; WANG, Li-Sheng; DUFFY, Noah, H.; JOHNS, Adam, M.; RODAK, Nicholas, J.; FIAMENGO, Bryan, A.; PHILLIPS, John, H.; (127 pag.)WO2017/53690; (2017); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

855-38-9, Tris(4-methoxyphenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,855-38-9

A mixture of 2-(8-bromodecyl)isoindoline-1 ,3-dione (0.91 g, 2.70 mmol) and tris(4- methoxyphenyl)phosphine (1 g, 2.84 mmol) in MeCN (10 mL) was heated at 70 C overnight. On cooling the solvent was removed in vacuo and the resulting residue purified by column chromatography eluting with 10% MeOH in DCM to give [8-(1 ,3-dioxo-2,3- dihydro-1 H-isoindol-2-yl)octyl]tris(4-methoxyphenyl)phosphonium bromide (1 .56 g, 82%) as a white foam. 1 H NMR (Method A) (DMSO-d6): delta (delta) ppm 7.88-7.81 (4H, m), 7.65 (6H, m), 7.28 (6H, m), 3.88 (9H, s), 3.54 (2H, t), 3.31 (2H, m), 1 .61 -1.36 (6H, m), 1 .23 (6H, m); 31 P NMR (162 MHz, DMSO-d6): delta ppm +21.7 ppm; LC-MS (Method G) 610 [M]+; RT 2.13 min

The synthetic route of 855-38-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NOVINTUM BIOTECHNOLOGY GMBH; SPAREY, Tim; RATCLIFFE, Andrew; STEVENSON, Brett; LAGASSE, Franz; COCHRANE, Edward; LASSALLE, Gilbert; (104 pag.)WO2018/193111; (2018); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

5518-52-5, Tri(furan-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5518-52-5, A solution of 10-bromomethyl-10-desmethyl- erythralosamine N-oxide (4) (0.196 g, 0.310 mmol) in NMP (3 ml) was degassed and tris (2-furyl) phosphine (0.018 g, 0.077 mmol) and PD2DBA3. CHC13 (0.010 G, 0.010 mmol) added. The reaction mixture was heated at 50 C for 10 min and more tris (2-furyl) phosphine (0.12 ml, 0.372 mmol) added. The reaction mixture was heated at 80C for 22 h. The product was extracted with ethyl acetate, the organic phase washed with aqueous sodium hydrogen carbonate, brine and dried (MGSOG). The NMP was removed under reduced pressure and the residual material subjected to flash chromatography on silica gel using CH2C12 : MEOH : NH3 90: 4: 1, yield 0.096 g (51%) of a white crystalline solid. HRMS: [M+1] 606.3654. Calc. for C33HS1NO9 : 606.3636.

As the paragraph descriping shows that 5518-52-5 is playing an increasingly important role.

Reference£º
Patent; ALPHARMA APS; COCKBAIN, Julian; WO2004/56843; (2004); A2;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

1608-26-0, N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In an eggplant-shaped two-neck flask equipped with a reflux condenser, a dropping funnel and a magnetic stirrer, 37.4 g (178 mmol) of diethylsulfate were added dropwise to 24.2 g (149 mmol) of hexamethylphosphorous triamide at room temperature in a nitrogen gas atmosphere. After 3-day stirring at room temperature, a white solid salt was obtained. The salt was washed sufficiently with ether and vacuum-dried at 50 C. for 5 hours to obtain tri(dimethylamino)butylphosphonium butylsulfate with 94% yield.The resulting compound was identified with a nuclear magnetic resonance spectrometer (BRUKER Ultra Shield 300 NMR Spectrometer, supplied by BRUKER Corp.). The spectrum data are shown below.1H-NMR (300 MHz, solvent: acetone-d6, reference material: tetramethylsilane) delta 3.83 (t, 2H) 2.85 (d, 18H) 2.73-2.63 (m, 2H) 1.70-1.33 (m, 8H) 0.97 (t, 3H) 0.90 (t, 3H)The structural formula is shown below (a dashed line in the formula represents a conjugated structure).

1608-26-0, 1608-26-0 N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine 15355, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Kanto Denka Kogyo Co., Ltd.; US2009/23954; (2009); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13440-07-8,Di(naphthalen-1-yl)phosphine oxide,as a common compound, the synthetic route is as follows.

In a nitrogen atmosphere, in a glove box, Add 0.01 mmol of nickel chloride and 0.52 mmol of bis-naphthylphosphine, respectively. 1.5 equivalents of t-BuOK (potassium tert-butoxide), sequentially added to the Schlenk reaction tube, Subsequently, 0.4 mmol of phenylpropanonitrile compound was added,Vacuuming and backfilling with nitrogen; under a nitrogen atmosphere, The solvent was added to 3 ml of 1,4-dioxane, and the reaction was continued at 120 C for 16 h. After the reaction is completed, it is cooled to room temperature and separated by column chromatography. That is the target product: Phenylethylnaphthylphosphine oxide with a yield of 99%., 13440-07-8

The synthetic route of 13440-07-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Hunan University; Zhang Jishu; Qi Tafamingrenqingqiubugongkaixingming; (13 pag.)CN109438512; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13440-07-8,Di(naphthalen-1-yl)phosphine oxide,as a common compound, the synthetic route is as follows.

Add 4-bromophenylacetylene (0.088 g, 0.5 mmol) to the reaction flask.Dinaphthylphosphorus (0.30 g, 1 mmol),CuCl (0.01 g, 0.1 mmol), tert-butyl peroxybenzoate(0.15 g, 1.5 mmol) and N-methylpyrrolidone(2 mL), 70oC reaction;TLC tracks the reaction until it is completely over;The crude product obtained after the completion of the reaction was separated by column chromatography (ethyl acetate: petroleum ether = 1:1) to give the desired product.(Yield 81%)., 13440-07-8

The synthetic route of 13440-07-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Nantong Textile Silk Industrial Technology Institute; Soochow University (Suzhou); Zou Jianping; Tao Zekun; Lv Shuaishuai; Li Chengkun; Li Jianan; (12 pag.)CN109096336; (2018); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6224-63-1,Tri-m-tolylphosphine,as a common compound, the synthetic route is as follows.

General procedure: 4.3.23 methyl 2-phenyl-5-(3-methylphenyl)thiazole-4-carboxylate (4b) A suspension of Pd(OAc)2 (10 mol percent), Ar3P (0.33 mmol or 0.75 mmol), AgOAc (3.0 mmol), TFA (1.0 mmol) and azole-4-carboxylates (0.5 mmol) in NMP (2 mL) was introduced to a Schlenk tube. After stirring at 120 C under argon for 24 h (reactions with 0.33 mmol of Ph3P), or 48 h (reactions with 0.75 mmol of Ph3P), the reaction mixture was diluted with ethyl acetate, and then filtered through a pad of Celite. Volatiles were removed in vacuo to give the crude products, which was purified by flash column chromatography on silica gel to afford pure arylated products Yield 125 mg (81percent). 1H NMR (300 MHz, CDCl3) delta 2.41 (s, 3H), 3.86 (s, 3H), 7.23-7.34 (m, 4H), 7.44-7.46 (m, 3H), 7.96-7.99 (m, 2H) ppm; 13C NMR (75 MHz, CDCl3) delta 165.0, 161.7, 145.6, 139.8, 137.0, 131.8, 129.6, 129.5, 129.2, 129.1, 128.0, 127.2, 126.0, 125.8, 51.3, 20.4 ppm., 6224-63-1

6224-63-1 Tri-m-tolylphosphine 80362, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Li, Ziyuan; Zhou, Haipin; Xu, Jinyi; Wu, Xiaoming; Yao, Hequan; Tetrahedron; vol. 69; 15; (2013); p. 3281 – 3286;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate