With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.18437-78-0,Tris(4-fluorophenyl)phosphine,as a common compound, the synthetic route is as follows.
To a solution of complex 1 (0.086 g, 0.2 mmol) and P(4-C6H4F)3 (0.063 g, 0.2 mmol) in CH2Cl2 was added asolution of Me3NO*2H2O (0.026 g, 0.23 mmol) in MeCN.The mixture was stirred at room temperature for 1 h, and then the solvent was reduced on a rotary evaporator. The residue was subjected to TLC using petroleum ether aseluent. The main red band afforded 0.101 g (70 percent) ofcomplex 5 as a red solid. IR (KBr disk, cm-1): mC:O 2049(vs), 1983 (vs), 1937 (vs). 1H NMR (500 MHz, CDCl3):7.49?7.45 (m, 6H, PPhH), 7.05 (t, J = 8 Hz, 6H, PPhH),6.53 (d, J = 7.5 Hz, 1H, 6-PhH), 6.22 (s, 1H, 2-PhH), 6.06(d, J = 7.5 Hz, 1H, 6-PhH), 1.86 (s, 3H, CH3) ppm. 31P{1H} NMR (200 MHz, CDCl3, 85percent H3PO4): 60.54(s) ppm. 13C{1H} NMR (125 MHz, CDCl3): 213.50 (d, 2JP-C= 7.2 Hz, PFeCO), 213.22 (d, 2JP-C = 6.7 Hz, PFeCO),208.96 (CO), 163.73 (dd, 4JP-C = 1.4 Hz, 1JF-C =250.9 Hz, p-PPhC), 147.92 (d, JP-C = 2.4 Hz, C6H3C), 143.92(d, JP-C = 2.5 Hz, C6H3C), 135.78, 128.92, 127.00, 125.72(4 s, C6H3C), 135.15 (dd, 2JP-C = 12.9 Hz, 3JF-C = 8.2 Hz, o-PPhC), 131.46 (dd, 1JP-C = 41.5 Hz, 4JF-C = 3.3 Hz, i-PPhC),115.81 (dd, 3JP-C = 10.7 Hz, 2JF-C = 21.2 Hz, m-PPhC),20.28 (CH3) ppm.
18437-78-0, As the paragraph descriping shows that 18437-78-0 is playing an increasingly important role.
Reference£º
Article; Liu, Xu-Feng; Transition Metal Chemistry; vol. 41; 5; (2016); p. 547 – 554;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate