Day: October 21, 2020

7650-91-1, Benzyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7650-91-1, General procedure: The following procedure was used in place of the general procedure for this reaction: SiO2 (0.0561 g) and di-(mu-acetato)bis-{2-[(N,N-dimethylamino)methyl]phenyl-C,N}dipalladium(II) 1a (0.0222 g, 0.0370 mmol) were mixed first in a small round-bottomed flask. A stir bar was inserted and the flask, septum, and stirring spatula were all transferred to a glove box with an atmosphere of N2. Benzyldiphenylphosphine 7 (0.020 g, 0.072 mmol) was then added to the flask and thoroughly mixed with the spatula. The reaction was allowed to stir at room temperature in the glove box. The flask was capped with the septum before being removed from the glove box and put in a preheated oil bath (100 C) for 2 h. No CaCl2-filled syringe was used in this reaction. The reaction mixture was filtered into a flask with LiCl as described in the general procedure and purified using preparative TLC in CH2Cl2.

The synthetic route of 7650-91-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Lamb, Jessica R.; Stepanova, Valeria A.; Smoliakova, Irina P.; Polyhedron; vol. 53; (2013); p. 202 – 207;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.146960-90-9,1,1′-Bis(dicyclohexylphosphino)ferrocene,as a common compound, the synthetic route is as follows.

Example 21 Preparation of[DCyPFc RuCI2AMPY] Into a 200 mL stirred glass reactor are introduced 3.2 g of RuCI2(PPh3)3and 2.32 g of DCyPFc as solids followed by 100 mL of nitrogen saturated MEK. Stirring is started immediately and the slurry is stirred for 28 hours.3P{ H} NMR analysis of a NMR sample obtained by diluting a sample from the reaction mixture with C6D6shows that all DCyPFc has reacted and that the only free phosphine is PPh3released from RuCI2(PPh3)3.To the intermediate slurried in MEK is added 0.42 g of AMPY after dilution in 10 ml of MEK over the period of 10 minutes. The reaction mixture is stirred for 60 hours. The obtained thick slurry of a tan brown product is suction filtered using a Buechner funnel and filter paper until a wet cake of product is obtained. Washing with MEK is continued until the MEK filtrate is uncoloured. The yellow product is dried at 10 mbar, 30C for 48 hours. A sample was slurried in IPA and again filtered.The identity of the solid is confirmed by a combination of H and3P{ H} NMR analysis. By3P{ H} NMR analysis 2 isomers with delta = 51 ppm (major broad resonance) and delta = 48 ppm (minor broad resonance) are visible. The AMPY resonances for the major complex are delta = 9.94 (d), 7.73 (t), 7.40 (t), 7.35 (t) (all integration as 0.75 H) 5.07 (s, 1 .5 H), the AMPY resonances for the minor complex are delta = 9.80 (d), 8.06 (t), 7.93 (t), 7.64 (t) (all integration as 0.25 H), 5.01 (s, 0.5 H). The 2 x 4 CH resonances of ferrocene are at delta = 4.23 (m), 4.08 (m). The remaining resonances of the cyclohexyl – resonances (44) are a broad series of multiplets at delta = 2.2 – 0.94 ppm., 146960-90-9

The synthetic route of 146960-90-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; JOHNSON MATTHEY PUBLIC LIMITED COMPANY; FACCHETTI, Sarah; NEDDEN, Hans; WO2015/79207; (2015); A2;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

17261-28-8, 2-(Diphenylphosphino)benzoic acid is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of acetato complex 3 (26.7 mg, 0.04 mmol) in CH2Cl2 (5 mL), a solution of 2-(diphenylphosphino)benzoic acid (24.6 mg, 0.08 mmol) in CH2Cl2 (5 mL) was added. The reaction mixture was stirred at ambient temperature for 5 h. The resulting solution was concentrated to half of the initial volume, and n-hexane(20 mL) was added. The precipitate was collected and dried in vacuo affording the product as a white powder (14.7 mg, 0.03 mmol, 75percent). 1H NMR (600 MHz, CDCl3):d 9.14 (s, 1 H, Hh), 8.30?8.28 (m, 1 H, Dpb?H), 7.71 (t, 1H, Hf, 3JH,H = 6 Hz), 7.48?7.26 (m, 12 H, He, Hg, Dpb?H), 6.95 (d, 1 H, Hd, 3JH,H = 6 Hz), 6.85?6.80 (m, 2 H, Ha,Dpb?H), 6.72 (t, 1 H, Hc, 3JH,H = 6 Hz), 6.36 (t, 1 H, Hb,3JH,H = 6 Hz), 4.28 (br s, 2 H, CH2). 13C NMR (150 MHz,CDCl3): d 170.5 (d, CO, 3JC,P = 4.2 Hz), 158.7 (Ck), 151.3(Ch), 148.2 (d, Cj, 2JC,P = 1.5 Hz), 143.7 (d, Dpb?C,JC,P = 13 Hz), 140.9 (d, Ca, 3JC,P = 12 Hz), 139.4 (Cf),138.8 (Ci), 135.3 (d, Dpb?C, JC,P = 13 Hz), 133.8 (d,Dpb?C, JC,P = 9 Hz), 132.1 (d, Dpb?C, JC,P = 4.5 Hz),131.4 (d, Dpb?C, JC,P = 1.5 Hz), 130.1 (d, Dpb?C,JC,P = 9 Hz), 129.2, 128.5, 128.2 (Dpb?C), 127.1 (Cd),126.0 (d, Cb, 4JC,P = 4.5 Hz), 124.3 (Cc), 124.1 (d, Ce,4JC,P = 3 Hz), 123.0 (d, Cg, 4JC,P = 3 Hz), 49.9 (CH2).31P NMR (100 MHz, CDCl3): d 33.2 (s, PDbp). ESI?MS(positive) m/z: 580 [M ? H]?. mmax/cm-1 (KBr): 1609(CO). Anal. Calcd. for C31H25NO2PPd: C, 64.20; H, 4.17;N, 2.42percent; Found: C, 64.11; H, 4.546; N, 2.14percent., 17261-28-8

17261-28-8 2-(Diphenylphosphino)benzoic acid 87021, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Zhang, Xin; Wang, Haiying; Yuan, Jiali; Guo, Shuai; Transition Metal Chemistry; vol. 42; 8; (2017); p. 727 – 738;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

24171-89-9, Tri(thiophen-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of [Fe2(CO)6(mu-SCH2CH2S)] (0.037 g, 0.1 mmol) and tricyclohexylphosphine (0.028 g, 0.1 mmol) in CH2Cl2 (5 mL) was added a solution of Me3NO¡¤2H2O (0.011 g, 0.1 mmol) in MeCN (5 mL). The mixture was stirred at room temperature for 1 h, and then, the solvent was reduced on a rotary evaporator. The residue was subjected to TLC using CH2Cl2/petroleum ether = 1:3 (v/v) as eluent. From the main red band, 0.042 g (68%) of complex 2 was obtained as a red solid., 24171-89-9

The synthetic route of 24171-89-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Yan, Lin; Li, Ao; Xiao, Qi-Min; Liu, Xu-Feng; Li, Yu-Long; Jiang, Zhong-Qing; Wu, Hong-Ke; Transition Metal Chemistry; vol. 44; 5; (2019); p. 483 – 489;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.224311-51-7,2-(Di-tert-Butylphosphino)biphenyl,as a common compound, the synthetic route is as follows.

50 ml entgastes, wasserfreies Methanol wurde auf Rueckflusstemperatur erhitzt, 2,36 g (7,9 mmol) 2-(Di-tert.-butylphosphino)biphenyl wurde langsam dem Methanol zugegeben, bis die Phosphin-Verbindung vollstaendig geloest war. Anschliessend wurde 0,59 g (2,6 mmol) Kupfer(II)-bromid portionsweise der Loesung zugegeben. Nach Zugabe des Kupferbromids wurde die Loesung noch weitere 15 min lang auf Rueckflusstemperatur erhitzt und danach die Loesung abgekuehlt. Nach Abkuehlen der Loesung fiel ein Feststoff aus, der abfiltriert wurde und mit wenig Ethanol und Diethylether gewaschen und anschliessend getrocknet wurde. Man erhielt 0,93 g (1,1 mmol) der oben genannten Verbindung. Die Ausbeute betrug 80 percent d. Th.

224311-51-7, 224311-51-7 2-(Di-tert-Butylphosphino)biphenyl 2734215, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Bayer Aktiengesellschaft; EP1437340; (2004); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

166330-10-5, (Oxybis(2,1-phenylene))bis(diphenylphosphine) is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Under argon protection, bis(2-diphenylphosphinophenyl)ether (Compound 2) 538 g, toluene solvent was added to the reaction vessel.700 mL, 8.8 mL of trifluoromethanesulfonic acid, 150 mL of acetone, the reaction system was heated to 200 C, and after 16 h of reaction, it was reduced toAt room temperature, after extraction, drying and recrystallization, the desired product 4,5-bisdiphenylphosphino-9,9-dimethyloxaxan (Compound 1) is obtained.549 g (yield 95%)., 166330-10-5

166330-10-5 (Oxybis(2,1-phenylene))bis(diphenylphosphine) 4285986, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Henan Academy Of Sciences Chemical Institute Co., Ltd.; Liu Tingting; Chen Hui; Zhou Duo; Zhao Shunwei; Li Yunfei; Yang Zhenqiang; Cui Fumin; Duan Zheng; Yang Ruina; (4 pag.)CN109942631; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17261-28-8,2-(Diphenylphosphino)benzoic acid,as a common compound, the synthetic route is as follows.

17261-28-8, Compound 1 (386 mg, 1 mmol), 2-(diphenylphosphino)benzoic acid (306 mg, 1 mmol), DIEA (129 mg, 1 mmol), and 2-(7-aza-1H-benzotriazole-1-yl)-1,1,3,3- tetramethyluronium hexafluorophosphate (HATU) (380 mg, 1 mmol) were dissolved in anhydrous CH2Cl2. The reaction mixture was stirred at room temperature for 12 h under argon atmosphere, tracked with TLC. And then the mixture was poured into water and extracted with CH2Cl2. The organic layer was separated, washed with saturated salt water, and dried over Na2SO4. The solvent was evaporated and the crude product of 2 was purified by column chromatography over silica gel, and eluted with CH2Cl2/petroleum ether (15:1) gave 2 as white solid (235 mg, 35percent). MP: 210 – 212 oC. 1H NMR (400 MHz, CDCl3) delta (ppm) 8.02 (d, J = 7.5 Hz, 1H), 7.70 – 7.59 (m, 4H), 7.40 – 7.17 (m, 15 H), 6.96 – 6.93 (m, 1H), 6.54 (d, J = 8.9 Hz, 1H), 6.44 (d, J = 2.4 Hz, 1H), 6.35 (dd, J = 8.8 Hz, 2.4 Hz, 1H), 6.26 (d, J = 2.1 Hz, 1H), 3.36 (q, J = 7.0 Hz, 4H), 1.17 (t, J = 7.0 Hz, 6H). 13C NMR (100 MHz, CDCl3): 169.69, 167.09, 153.27, 152.84, 149.74, 148.67, 141.36, 141.11, 135.04, 134.40, 134.21 134.17, 134.11, 134.01, 133.97, 133.90, 132.98, 130.58, 129.67, 129.49, 129.18, 128.99, 128.92, 128.84, 128.77, 128.69, 128.56, 128.51, 126.97, 124.97, 124.25 123.59, 119.44, 118.90, 117.61, 108.51, 104.77, 97.68, 83.99, 44.60, 12.63. 31P NMR (161.9 MHz, CDCl3) delta (ppm): -10.268. HRMS: calcd. m/z 675.2413 [M + H]+; m/z 1349.4747 [2M + H]+, found m/z 675.2419 [M + H]+; m/z 1349.4761 [2M + H]+.

The synthetic route of 17261-28-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Huang, Kun; He, Song; Zeng, Xianshun; Tetrahedron Letters; vol. 58; 20; (2017); p. 2004 – 2008;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1608-26-0,N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine,as a common compound, the synthetic route is as follows.

The ligand precursor HP(OCH2CHi-PrNH)2 (2S,8S)-2,8-isopropyl-4,6-dioxa-1,9-diaza-5lambda5-phosphaspiro[4.4]nonane 1 was obtained using the general procedure described in the literature [9] A mixture of P(NMe2)3 (1.14?cm3, 6.27?mmol) and (S)-(+)-2-amino-3-methyl-butanol (CH3)2CHCH(NH2)CH2OH (0.31?g, 12.6?mmol) and 6?cm3 of toluene was placed in a round-bottomed flask equipped with a magnetic stirrer and a reflux condenser, and then heated gradually to 100?C over 2?h with gentle argon purging. The progress of the reaction was monitored by GC-MS analyses. The crude product (white solid) was purified by recrystallization from hexane in a freezer providing crystals suitable for X-ray analysis. Yield: 1.14?g (78%). Anal. Calc. for C10H23N2O2P: C, 51.27; H, 9.90; N, 11.96 Found: C, 50.82; H, 9.78; N, 11.6%; 1H NMR (CD2Cl2) major epimer 1a: delta 0.80, 0.89 (12H, d, 3J(H, H)?=?7?Hz, CH3), 1.45 (2H, m, CH), 2.87 (4H, m, CH, NH), 3.33 (2H, ddd, 2J(H, H)?=?8.9?Hz, 3J(H, H)?=?5.7?Hz, 3J(P, H)?=?10.00?Hz, CH2), 3.77 (2H, ddd, 2J(H, H)?=?8.9?Hz, 3J(H, H)?=?6.3?Hz, 3J(P, H)?=?11.36?Hz, CH2), 6.74 (1H, d 1J(P, H)?=?741.1?Hz, PH); minor epimer 1b: delta 0.84, 0.90 (12H, d, 3J(H, H)?=?7?Hz, CH3), 1.52 (2H, m, CH), 2.87 (4H, m, CH, NH), 3.48 (2H, ddd, 2J(H, H)?=?8.9?Hz, 3J(H, H)?=?4.9?Hz, 3J(P, H)?=?11.45?Hz, CH2), 3.69 (2H, ddd, 2J(H, H)?=?8.9?Hz, 3J(H, H)?=?6.5?Hz, 3J(P, H)?=?9.71?Hz, CH2), 6.76 (1H, d 1J(P, H)?=?727.3?Hz, PH) 31P {1H} NMR (CD2Cl2) delta – 53.73 (minor signal), -54.16 (major signal) ppm; IR numax(nujol)/cm-1 658vs, 953vs, 988vs, 1050vs, 1156?m nu(C-O-P), 2347?s 2360?s nu(P-H), 3324?s, nu(N-H); ESI-MS: m/z calcd for [M?+?H]+ 236.14 found 236.14; Deltaepsilon223?=?-0.43, 1608-26-0

1608-26-0 N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine 15355, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Skar?y?ska, Anna; Gniewek, Andrzej; Inorganica Chimica Acta; vol. 483; (2018); p. 248 – 251;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.18437-78-0,Tris(4-fluorophenyl)phosphine,as a common compound, the synthetic route is as follows.

To a solution of complex 1 (0.086 g, 0.2 mmol) and P(4-C6H4F)3 (0.063 g, 0.2 mmol) in CH2Cl2 was added asolution of Me3NO*2H2O (0.026 g, 0.23 mmol) in MeCN.The mixture was stirred at room temperature for 1 h, and then the solvent was reduced on a rotary evaporator. The residue was subjected to TLC using petroleum ether aseluent. The main red band afforded 0.101 g (70 percent) ofcomplex 5 as a red solid. IR (KBr disk, cm-1): mC:O 2049(vs), 1983 (vs), 1937 (vs). 1H NMR (500 MHz, CDCl3):7.49?7.45 (m, 6H, PPhH), 7.05 (t, J = 8 Hz, 6H, PPhH),6.53 (d, J = 7.5 Hz, 1H, 6-PhH), 6.22 (s, 1H, 2-PhH), 6.06(d, J = 7.5 Hz, 1H, 6-PhH), 1.86 (s, 3H, CH3) ppm. 31P{1H} NMR (200 MHz, CDCl3, 85percent H3PO4): 60.54(s) ppm. 13C{1H} NMR (125 MHz, CDCl3): 213.50 (d, 2JP-C= 7.2 Hz, PFeCO), 213.22 (d, 2JP-C = 6.7 Hz, PFeCO),208.96 (CO), 163.73 (dd, 4JP-C = 1.4 Hz, 1JF-C =250.9 Hz, p-PPhC), 147.92 (d, JP-C = 2.4 Hz, C6H3C), 143.92(d, JP-C = 2.5 Hz, C6H3C), 135.78, 128.92, 127.00, 125.72(4 s, C6H3C), 135.15 (dd, 2JP-C = 12.9 Hz, 3JF-C = 8.2 Hz, o-PPhC), 131.46 (dd, 1JP-C = 41.5 Hz, 4JF-C = 3.3 Hz, i-PPhC),115.81 (dd, 3JP-C = 10.7 Hz, 2JF-C = 21.2 Hz, m-PPhC),20.28 (CH3) ppm.

18437-78-0, As the paragraph descriping shows that 18437-78-0 is playing an increasingly important role.

Reference£º
Article; Liu, Xu-Feng; Transition Metal Chemistry; vol. 41; 5; (2016); p. 547 – 554;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.12150-46-8,1,1-Bis(diphenylphosphino)ferrocene,as a common compound, the synthetic route is as follows.

The solutions of (0.0256 g, 0.1 mmol) of H2dzin 10 cm3 of methanol, (0.1 mmol, 0.0233 g) ofMnCl2.6H2O in 10 cm3 of methanol) and (0.0554 g,0.1mmol of 1,1′-bis(diphenyl phosphine) ferrocene(dppf) were mixed and refluxed at 55 oC for 2 h to give brown colored precipitate and the solutionswas filtered and finally it was dried in an open air.Yield=81percent, d.p= 238¡ãC. Anal. Calc. percent for C47 H41 ClN4 P2Mn S Fe:C, 62.58; H, 4.58; N, 6.21, S, 3.55, Mn,6.09, Cl, 3,93 .Found percent: C, 62.87, H, 4.82; N, 6.53, S;3.88, Mn; 6.27, Cl.4.11.

12150-46-8, The synthetic route of 12150-46-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Mohamad, Hikmat Ali; Oriental Journal of Chemistry; vol. 34; 4; (2018); p. 1919 – 1925;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate