With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17261-28-8,2-(Diphenylphosphino)benzoic acid,as a common compound, the synthetic route is as follows.
3-Amino-2-naphthol (0.159 g, 1.0 mmol), 2-(diphenylphosphino)benzoic acid (0.306 g,1.0 mmol) and p-toluene sulfonic acid (0.190 g, 1.0 mmol) were added to toluene (30 mL).The mixture was heated to 150C for 15 hr under nitrogen. The progress of reaction wasmonitored by TLC. After the reaction mixture cooled, the solution was extracted withwater, and the organic solution was evaporated. Then the crude intermediate in 10 mLdichloromethane were stirred in a round-bottom flask, and then H2O2 (1.2 mL, 10 mmol,30percent) was slowly added into the mixture while stirring at room temperature. The organic layer was separated and washed with water. The extract was evaporated to dryness affordinga pale yellow solid. The residue was dissolved in CHCl3 and added to methanol in orderto get solid precipitate. The crude product was purified by column chromatography withCHCl3: ethyl acetate (5:1) eluent to afford pale yellow solid (0.222 g, yield 50percent)., 17261-28-8
As the paragraph descriping shows that 17261-28-8 is playing an increasingly important role.
Reference£º
Article; Kim, Ik-Hwan; Kang, Eunguk; Kim, Dong-Eun; Shin, Hoon-Kyu; Lee, Burm-Jong; Molecular Crystals and Liquid Crystals; vol. 597; 1; (2014); p. 88 – 94;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate