Day: October 20, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13991-08-7,1,2-Bis(diphenylphosphino)benzene,as a common compound, the synthetic route is as follows.

A toluene solution (20mL) of 1 (22mg, 0.043mmol) and dppb (18mg, 0.043mmol) was refluxed under a nitrogen atmosphere for 27 h. The solvent was removed under reduced pressure and the residue was chromatographed by TLC on silica gel. Elution with cyclohexane/CH2Cl2 (4:1 v/v) developed two bands. The faster band was unreacted 1 (2mg) while the slower moving band afforded [Fe2(CO)5{mu,kappa2-C6H4PPh(C6H4)PPh2}(mu-PFu2)] (7) (20mg, 66%) as red crystals after recrystallization from hexane/CH2Cl2 at 4C. Spectral data for 7: Anal. Calcd for C39H29Fe2O7P3: C, 57.52; H, 3.60. Found: C, 57.62; H, 3.88%. IR (nu(CO), CH2Cl2): 2023 s, 1983 vs, 1945 w cm-1. 1H NMR (CDCl3): delta 5.72-5.63 (m, 1H, Fu), 6.08 (m, 1H, Fu), 6.20 (m, 1H, Fu), 6.29 (m, 2H, Fu), 6.31 (m, 1H, Fu), 6.53-6.41 (m, 2H, Ph), 6.83-6.80 (m, 3H, Ph), 7.18-7.10 (m, 5H, Ph), 7.48-7.30 (m, 9H, Ph), 7.96-7.62 (m, 4H, Ph). 31P{1H} NMR (CDCl3): delta 138.7 (dd, J=54, 30Hz), 90.5 (t, J=55Hz), 82.7 (dd, J=50, 30Hz)., 13991-08-7

As the paragraph descriping shows that 13991-08-7 is playing an increasingly important role.

Reference£º
Article; Rahaman, Ahibur; Alam, Fakir Rafiqul; Ghosh, Shishir; Tocher, Derek A.; Haukka, Matti; Kabir, Shariff E.; Nordlander, Ebbe; Hogarth, Graeme; Journal of Organometallic Chemistry; vol. 751; (2014); p. 326 – 335;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4020-99-9,Methoxydiphenylphosphine,as a common compound, the synthetic route is as follows.

General procedure: Using the same stoichiometric ratio than in the previous reactions, the hexane solution was stirred at room temperature for 5 days. Then 5 mL of ethanol were added and the solution stirred for another 5 days. The solvent was then evaporated under vacuum and the residue purifiedby TLC. Compound 8d was obtained in 63% yield.

4020-99-9, As the paragraph descriping shows that 4020-99-9 is playing an increasingly important role.

Reference£º
Article; Gonzalez-Lopez, Vianney; Torres-Sandoval, Indira; Carrasco-Gonzalez, Ana L.; Elias-Jimenez, Adonay; Leyva, Marco A.; Rosales-Hoz, Maria J.; Cruz-Borbolla, Julian; Zuno-Cruz, Francisco J.; Sanchez-Cabrera, Gloria; Jardinez, Christian; Inorganica Chimica Acta; vol. 492; (2019); p. 8 – 17;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

564483-19-8, Di-tert-butyl(2′,4′,6′-triisopropyl-[1,1′-biphenyl]-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

564483-19-8, Example 558 52 mg of tert-butyl 5-hydroxy-1H-indole-1-carboxylate, 79 mg of tripotassium phosphate, 4.7 mg of 2-(di-tert-butylphosphino)-2′,4′,6′-triisopropylbiphenyl and 6.8 mg of tris(dibenzylideneacetone)dipalladium(0) were added to 1.4 mL of toluene solution containing 70 mg of tert-butyl 2-(benzamido)-4-bromobenzoate at room temperature, and the resulting mixture was heated to reflux under nitrogen atmosphere for 2 hours and 30 minutes. After the reaction mixture was cooled to room temperature, ethyl acetate and 10% citric acid aqueous solution were added and insoluble were removed by filtration. The organic layer was separated and dried over anhydrous magnesium sulfate after washed with a saturated sodium chloride aqueous solution, and the solvent was evaporated under reduced pressure. The obtained residue was purified with silica gel column chromatography [PSQ100B (spherical) manufactured by Fuji Silysia Chemical Ltd., eluent; hexane: ethyl acetate = 10:1] to obtain tert-butyl 5-(3-(benzamido)-4-(tert-butoxycarbonyl)phenoxy)-1H-indole-1-carboxylate.

As the paragraph descriping shows that 564483-19-8 is playing an increasingly important role.

Reference£º
Patent; TOYAMA CHEMICAL CO., LTD.; EP1820795; (2007); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

17261-28-8, 2-(Diphenylphosphino)benzoic acid is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a round bottom flask were added 2-(diphenylphosphino)benzoic acid (17.94 mg, 0.058 mmol) and 3 mL of DMF. To the solution were added 1-O-(N,N’,N,N’tetramethyluronium)azabenzotriazoloxy hexafluorophosphate (26.73 mg, 0.070 mmol), 1-hydroxyazabenzotriazole (9.56 mg, 0.070 mmol), and diisopropylethylamine (45.4 mg, 0.0612 mL). After stirring the reaction mixture for 7 minutes, N-alpha-(6-(2-(2-sulfonatobenzaldehyde)hydrazono)nicotinyl)lysine methyl ester hydrochloride (35.2 mg, 0.070 mmol) dissolved in 4 ml of DMF was added to the above mixture. The reaction mixture was stirred for 2 hours. The solvent was removed in vacuo and the resulting crude oil was subjected to HPLC purification using the method described above. The collected fractions were combined, and were lyophilized to give the product as a pale yellow solid. The yield was 29 mg (66percent) after HPLC purification., 17261-28-8

As the paragraph descriping shows that 17261-28-8 is playing an increasingly important role.

Reference£º
Patent; Liu, Shuang; US2005/8575; (2005); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

791-28-6, Triphenylphosphine oxide is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1. Hydrogenation of Triphenylphosphine Oxide; A mixture of triphenylphosphine oxide (707 g, 2.54 mol) and a suspension of ruthenium(IV) oxide hydrate (supported on aluminum oxide) (140 g, comprises 3 g of ruthenium) in tetrahydrofuran (2 l) was hydrogenated at from 120 to 150 C. and a hydrogen pressure of 250 bar with stirring. After cooling to room temperature, the catalyst was filtered off and the filtrate was freed of the solvent under reduced pressure. Distillation of the residue at from 200 to 210 C. (1 mbar) afforded 722 g (96% of theory) of tricyclohexylphosphine oxide in the form of a white solid., 791-28-6

The synthetic route of 791-28-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Basf SE; US2010/137643; (2010); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

4020-99-9, Methoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 1 (0.153 mmol) was dissolved in 30 ml of hexane and 2 equivalents of the phosphine (61.8 mg, 0.30 mmol) was added. Thesolution was stirred for 60 min. The reaction mixture was taken to dryness under vacuum and the residue separated by thin layer chromatography using hexane:methylene chloride (4:1) as eluant. Compound 4e. Yellow solid. IR (CH2Cl2, nuCO, cm-1):2076(m), 2052(s), 2040(w), 2012(vs), 1997(s), 1984(w). NMR (CDCl3): delta 1H:-21.59 (d, 3JPH=2.7 Hz, M-H-M), 0.31 (s, SiMe3), 3.56 (s, P(OMe)Ph2),7.41-7.7 (m, P(OMe)Ph2); delta 31P{H}: 119.7; delta 29Si{1H}:1.69., 4020-99-9

The synthetic route of 4020-99-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Gonzalez-Lopez, Vianney; Torres-Sandoval, Indira; Carrasco-Gonzalez, Ana L.; Elias-Jimenez, Adonay; Leyva, Marco A.; Rosales-Hoz, Maria J.; Cruz-Borbolla, Julian; Zuno-Cruz, Francisco J.; Sanchez-Cabrera, Gloria; Jardinez, Christian; Inorganica Chimica Acta; vol. 492; (2019); p. 8 – 17;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17261-28-8,2-(Diphenylphosphino)benzoic acid,as a common compound, the synthetic route is as follows.

3-Amino-2-naphthol (0.159 g, 1.0 mmol), 2-(diphenylphosphino)benzoic acid (0.306 g,1.0 mmol) and p-toluene sulfonic acid (0.190 g, 1.0 mmol) were added to toluene (30 mL).The mixture was heated to 150C for 15 hr under nitrogen. The progress of reaction wasmonitored by TLC. After the reaction mixture cooled, the solution was extracted withwater, and the organic solution was evaporated. Then the crude intermediate in 10 mLdichloromethane were stirred in a round-bottom flask, and then H2O2 (1.2 mL, 10 mmol,30percent) was slowly added into the mixture while stirring at room temperature. The organic layer was separated and washed with water. The extract was evaporated to dryness affordinga pale yellow solid. The residue was dissolved in CHCl3 and added to methanol in orderto get solid precipitate. The crude product was purified by column chromatography withCHCl3: ethyl acetate (5:1) eluent to afford pale yellow solid (0.222 g, yield 50percent)., 17261-28-8

As the paragraph descriping shows that 17261-28-8 is playing an increasingly important role.

Reference£º
Article; Kim, Ik-Hwan; Kang, Eunguk; Kim, Dong-Eun; Shin, Hoon-Kyu; Lee, Burm-Jong; Molecular Crystals and Liquid Crystals; vol. 597; 1; (2014); p. 88 – 94;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.255835-82-6,Dicyclohexyl(2′-methoxy-[1,1′-biphenyl]-2-yl)phosphine,as a common compound, the synthetic route is as follows.

Example 24 Synthesis of N-(4-methylphenyl)indole An oven-dried test tube was purged with argon and then charged with 2-dicyclohexylphosphino-2′-methoxy-1,1′-biphenyl (14.5 mg, 0.038 mmol, 7.5 mol %) and Pd2(dba)3 (11.6 mg, 0.013 mmol, 5.0 mol % Pd). Toluene (1.0 mL), indole (71 mg, 0.61 mmol), 4-chlorotoluene (60 mL, 0.51 mmol), and NaOt-Bu (70 mg, 0.73 mmol) were then added. The tube was fitted with a septum, purged with argon and heated at 100 C. for 28 h. The reaction was then cooled to room temperature, diluted with ether (20 mL), filtered through Celite and concentrated in vacuo. The residue was purified by flash chromatography on silica gel to afford 99 mg (94%) of a colorless oil.

255835-82-6, The synthetic route of 255835-82-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Buchwald, Stephen L.; Huang, Xiaohua; Zim, Danilo; US2004/171833; (2004); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17261-28-8,2-(Diphenylphosphino)benzoic acid,as a common compound, the synthetic route is as follows.

17261-28-8, Thus, crotonaldehyde was treated with HCN in the presence of an (R)-oxynitrilase readily obtained from grinding and scouring of bitter almonds,18 which gave the (R)-cyanohydrin with high levels of enantioselectivity (>96percent ee).19 Subjecting to the conditions of a Pinner reaction furnished the ethyl ester 20 (Scheme 6).20 The reduction with lithium aluminum hydride led to diol 21 and subsequent silylation furnished the silylether 22 on a multigram scale.21 Applying the standard Steglich esterification protocol22 with ortho-diphenylphosphanylbenzoic acid (o-DPPBA)23 provided o-DPPB-ester (R)-(+)-6 quantitatively. Crystallization of this product improved the enantiopurity to greater than 99percent ee. In order to obtain the requested (S)-enantiomer of 6 one could apply a corresponding (S)-oxynitrilase. However, such enzymes are far more difficult to access.24 Hence, we looked at a Mitsunobu inversion protocol, which ideally would use o-DPPBA itself as the nucleophile.25 Since o-DPPBA is both a carboxylic acid and a phosphine we expected this to be a non trivial reaction because the reagent triphenylphosphine as well as o-DPPBA may react with the azodicarboxylate electrophile. Interestingly, we observed a clean Mitsunobu reaction of the allylic alcohol 22 with o-DPPBA to furnish the corresponding (S)-(-)-enantiomer of o-DPPB-ester 6 in good yield (81percent). After recrystallization (S)-(-)-6 was obtained in >99percent enantiopurity.

The synthetic route of 17261-28-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Albert-Ludwigs-Universitat Freiburg; US2011/282075; (2011); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13991-08-7, 1,2-Bis(diphenylphosphino)benzene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

10119] In a schlenk flask provided with a teflon closure, a solution of Os(tetradentate ligand)(DMSO)2 (200 mg, 0.2 64 mmol) in THF (10 mL) was treated with 1,2-bis(diphe- nylphosphino)benzene (118 mg, 0.264 mmol). The resulting mixture was stirred at 100 C. for 60 hours to produce a yellow solution. Afier cooling at room temperature (.-22 C.), the solvent was removed in vacuo. After extraction with dichioromethane, the solid was filtered off and the solution was evaporated to dryness. Addition of 5 mL of acetonitrile caused precipitation of a yellow solid that was washed with thrther portions of acetonitrile (2×5 mL) and subsequently with diethyl ether (3×5 mL). The yellow solid was dried in vacuo. Yield: 215mg (68%). IR (cm?): v(C=C) 1570 (w). ?H NMR (500 MHz, CD2C12, 298 K): oe 8.00 (dd, JHH=7.0,JHH=1.5, 1H, CH), 7.63 (t, JHH=8.0, 2H, CH), 7.58 (m, 1H,CH), 7.53-7.50 (m, 3H, CH), 7.38 (d, 1H, CH), 7.35(d, H-H=, 1H, CH), 7.29-7.25 (m, 8H, CH), 7.16-7.14 (m,3H, CH), 7.08-7.00 (m, 3H, CH), 6.95-6.88 (m, 6H, CH),6.79-6.76 (m, 3H, CH), 6.73 (t, H-H=, 1H, CH), 6.63 (dt,JHH=1.0, JHH=7.2, 1H, CH), 6.59 (dt, JHH=1.0, JHH=7.0,1H, CH), 6.39-6.35 (m, 3H, CH), 6.30 (t, 6.30 (t, JHH=8.5,2H, CH), 5.80-5.74 (m, 1H, -CH2—-), 4.32-4.28 (m, 2H,-CH2-), 3.86-3.80 (m, 1H, -CH2-). ?3C{?H} NMR(125.68 MHz, CD2C12, 298 K): oe 210.9 (t, J=4.3, NCN),187.4 (dd, J,=7.9, J,=79.7, NCN), 158.1 (t, J=6.4,Os-C Ph), 153.9 (dd, J=12.5, J=55.5, Os-C Ph),151.7 (d J=3.2, Cq), 149.4 (d, J=3.8, Cq), 148.6 (dd,J=47.2, J=34.2, Cq), 144.9 (dd, J=41.9, J=36.3,Cq), 143.7 (d, J=5.4, Cq), 143.5 (d, J=5.4, CH), 142.3(s, CH), 138.3 (d, J=3.6, Cq), 137.2 (d, J=28.8, Cq),137.0, 136.7 (both s, Cq), 136.2 (d, J=9.7, CH), 133.8 (d,J=11.9, CH), 133.5 (dJ=3.3, Cq), 132.8 (d, J=14.8,CH), 132.3 (d, J,=1 .9, Cq), 132.2 (d, J=10.3, CH), 131.9(dd, J=6.9, J=31.8, Cq), 131.7 (d, J=13.9, CH),130.0 (d, j=9.3, CH), 129.6 (d, j=3.9, CH), 129.2,129.0 (both s, CH), 128.9 (d, J=3.6, CH), 128.3 (s, CH),127.9 (d, J=9.0, CH), 127.5, 127.4 (both s, CH), 127.2 (d,J=8.7, CH), 126.4 (d, J=8.4, CH), 123.3, 122.7, 122.5,122.0, 121.7,121.1, 120.4,119.3, 112.3,111.2, 111.1, 110.6,109.7, 107.3 (all s, CH), 47.5 (s, -CH2-), 45.0 (d, J=3.5,-CH2—-). 3?P{?H} NMR (121.4 MHz, CD2C12, 298 K): oe32.1 (d, j=s?s), 18.7 (d, J=5.5).

13991-08-7, 13991-08-7 1,2-Bis(diphenylphosphino)benzene 498379, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Universal Display Corporation; TSAI, Jui-Yi; XIA, Chuanjun; ESTERUELAS, Miguel A.; ALABAU, Roberto G.; OLIVAN, Montserrat; ONATE, Enrique; (89 pag.)US2016/240799; (2016); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate