Day: October 19, 2020

13689-19-5, Tricyclohexylphosphine oxide is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The same general procedure was adopted for the synthesis of all the complexes. The lanthanide bromide and tricyclohexylphosphineoxide were dissolved in hot ethanol. Heating was continued for 1 h during which time, in some cases, small quantities of crystalline material formed. Either cooling to room temperature followed by standing for 16 h or on prolonged standing and slow evaporation of the solution afforded crystalline materials. The crystals were filtered, washed with ethanol and dried at the pump. Representative syntheses and characterisations are described below.

13689-19-5, 13689-19-5 Tricyclohexylphosphine oxide 26187, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Bowden, Allen; Lees, Anthony M.J.; Platt, Andrew W.G.; Polyhedron; vol. 91; (2015); p. 110 – 119;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

247940-06-3, 2-(Dicyclohexylphosphino)biphenyl is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 76 3-[2-(2,4-Dichloro-Phenyl)-Ethoxy]-4-Methoxy-N-(1-Phenyl-piperidin-4-Ylmethyl)-Benzamide A mixture of 100 mg (0.2 mmol) 3-[2-(2,4-Dichloro-phenyl)-ethoxy]-4-methoxy-N-piperidin-4-ylmethyl-benzamide, 50 mg (0.32 mmol) Bromobenzene, 70 mg sodium-t-butoxide in 5 ml dioxane were purged with argon for 10 min. Then 37 mg of 2-(Dicyclohexylphosphino)biphenyl and 20 mg Pd2(dba)3 were added under argon and the mixture refluxed overnight. The residue was taken up in 3 ml saturated NaHCO3 solution and filtered through a chem elut cartridge by elution with ethyl acetate. Subsequent removal of the solvent under reduced pressure and purification by preparative HPLC (C18 reverse phase column, elution with a H2O/MeCN gradient with 0.5% TFA) the fractions containing the product were evaporated and lyophilised.

247940-06-3, The synthetic route of 247940-06-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Nazare, Marc; Will, David William; Peyman, Anuschirwan; Matter, Hans; Zoller, Gerhard; Gerlach, Uwe; US2002/198195; (2002); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

1608-26-0, N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Tris(dimethylamino)phosphine (1.64 g, 10 mmol) was added drop-wise to a stirred solution of methanol (0.32 g, 10 mmol) andCCl4 (1.77 g, 11.5 mmol) in dry CH2Cl2 (20 mL) cooled at 30 C.Then, 10 mL of distilled water was added and the reaction mixturewas allowed to proceed at room temperature for 2 h. Organic phasewas decanted and extracted with water (2 30 mL). Aqueousphases were collected, washed with Et2O and decanted to give anaqueous solution of methoxytris(dimethylamino)phosphonium chloride CH3OP(NMe2)3Cl., 1608-26-0

1608-26-0 N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine 15355, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Mechria, Ali; Dridi, Sana; Msaddek, Moncef; Inorganica Chimica Acta; vol. 427; (2015); p. 173 – 177;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

1608-26-0, N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a mixture of (S)-3,3′-Dibenzyl-5,5′,6,6′-tetramethyl-1,1′-biphenyl-2,2′-diol24 (0.42 g, 1.00 mmol) in toluene (5 mL) was added hexamethylphosphorous triamide (248 mg, 1.50 mmol) under nitrogen. The resulting mixture was stirred at 80 C for 17 h. The solvent was evaporated under reduced pressure to afford a gel-like product, which was further purified by column chromatography on silica gel (pretreated with 1% NEt3 in hexanes) using hexanes/EtOAc (19/1) as the eluent to give (R)-MPN-Lf (0.32 g, 65%) as a white solid: mp 110.0-112.0 C; [alpha]D22 -176.2 (c 0.5, CH2Cl2); 1H NMR (400 MHz, CDCl3) delta 1.94 (s, 3H), 2.01 (s, 3H), 2.22 (s, 3H), 2.23 (s, 3H), 2.52 (s, 3H), 2.55 (s, 3H), 3.70 (d, J=15.2 Hz, 1H), 4.17 (m, 1H), 6.86 (s, 1H), 6.91 (s, 1H), 7.28 (m, 10H); 31P NMR (121.5 MHz, CDCl3) delta 140.8; HRMS (EI) calcd for C24H26NO2P [M]+ 391.1701, found 391.1703 (Delta=+0.5 ppm)., 1608-26-0

As the paragraph descriping shows that 1608-26-0 is playing an increasingly important role.

Reference£º
Article; Chien, Chih-Wei; Shi, Ce; Lin, Chi-Feng; Ojima, Iwao; Tetrahedron; vol. 67; 35; (2011); p. 6513 – 6523;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13885-09-1,2-(Diphenylphosphino)biphenyl,as a common compound, the synthetic route is as follows.

General procedure: To a solution of [Fe2(CO)6(m-SCH2CH2S)] (0.037 g, 0.1 mmol) and tris(4-methylphenyl)-phosphine (0.032 g, 0.1 mmol) in CH2Cl2 (5 mL) was added a solution of Me3NO2H2O(0.011 g, 0.1 mmol) in MeCN (5 mL). The mixture was stirred at room temperature for1 h and then the solvent was reduced on a rotary evaporator. The residue was subjectedto TLC using CH2Cl2/petroleum ether1:5 (v/v) as eluent. From the main redband, 0.054 g (83%) of 2 was obtained as a red solid., 13885-09-1

As the paragraph descriping shows that 13885-09-1 is playing an increasingly important role.

Reference£º
Article; Yan, Lin; He, Jiao; Liu, Xu-Feng; Li, Yu-Long; Jiang, Zhong-Qing; Wu, Hong-Ke; Journal of Coordination Chemistry; vol. 72; 15; (2019); p. 2531 – 2543;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6163-58-2, Tri-o-tolylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(4R,9aR)-6-(2-Ethoxycarbonyl-vinyl)-4-methyl-3,4,9,9a-tetrahydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl ester To a solution of 1.0 g (2.71 mmol) (4R,9aR)-6-bromo-4-methyl-3,4,9,9a-tetrahydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl ester (Example 5, intermediate b) and 0.36 ml (3.25 mmol) ethyl acrylate in 30 ml toluene were added 0.67 g (8.15 mmol) sodium acetate, 82.6 mg (0.27 mmol) tri(o-tolyl)phosphine and 0.04 mg (0.1 mmol) allylpalladium chloride dimer. The reaction mixture was heated under reflux for 20 h, then poured into saturated aqueous sodium bicarbonate solution and extracted with ethyl acetate. The organic phase was washed with 10% aqueous citric acid solution and brine, dried over magnesium sulfate, filtered and evaporated. The crude product was purified by column chromatography on silica gel (0.032-0.063 mm) with n-hexane:ethyl acetate (9: 1) as eluant to afford the desired compound as a yellow solid (91.2%). ISP-MS: m/e=388.3 ([M+H+])

6163-58-2, The synthetic route of 6163-58-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Adams, David Reginald; Bentley, Jonathan Mark; Blench, Toby Jonathan; Hebeisen, Paul; Monck, Nathaniel Julius Thomas; Richter, Hans; Roever, Stephan; Roffey, Jonathan Richard Anthony; Taylor, Sven; US2003/207888; (2003); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

50777-76-9, 2-(Diphenylphosphino)benzaldehyde is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

50777-76-9, General procedure: To a dichloromethane solution (15 mL) of 2-diphenylphosphinobenzaldehyde (ca. 3 mmol) was added an equimolar amount of the appropriate substituted amine. An excess of magnesium sulphate was also added to the reaction mixture to remove the water by-product. The reaction was left to stir at room temperature for 16 h, after which time the magnesium sulphate was filtered off and the solvent removed from the filtrate in vacuo to give a yellowe orange oil. The oily crude products of ligands 1a-1f were solidified by dissolving the oil in hot hexane, followed by quick hot filtration of the liquid product. The resultant solution was then cooled at -16 ¡ãC overnight to give an off-white powder, which was filtered and dried in vacuo.

As the paragraph descriping shows that 50777-76-9 is playing an increasingly important role.

Reference£º
Article; Mogorosi, Mokgolela M.; Mahamo, Tebello; Moss, John R.; Mapolie, Selwyn F.; Slootweg, J. Chris; Lammertsma, Koop; Smith, Gregory S.; Journal of Organometallic Chemistry; vol. 696; 23; (2011); p. 3585 – 3592;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

607-01-2, Ethyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Compound 1a (30mg, 0.026mmol) and PPh3 (13mg, 0.052mmol) were added together in acetone (15cm3). The mixture was stirred for 24, and after concentration the resulting precipitate was filtered off and recrystallised from dichloromethane/hexane. Yield: 54.35%. Found C: 61.3, H: 4.8; N: 1.9; C42H41NClFeO2PPd (820.47g/mol) requires C: 61.5, H: 5.0, N: 1.7. IR numax/cm-1: 1598m (C=N), 308b (Pd-Cl). NMR 1H (CDCl3): deltaH=8.39 (d, 1H, HC=N, 4J(PH) 8.8) 6.88 (b, 2H, C6H2), 5,41 (s, 1H, CHO2), 4.28 [d, 1H, H3, 3J 2.4Hz], 4.14, 3.86, 2.08, 1.34 (m, 6H, CH2), 3.98 (s, 5H, C5H5), 3.35 [d, 1H, H4, 3J 2.4Hz], 2.46 (s, 3H, Me), 2.28 (s, 3H, Me), 2.26 (s, 3H, Me). NMR 31P (CDCl3): deltaP=36.4 s.

607-01-2, The synthetic route of 607-01-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Martinez, Javier; Marino, Marta; Caamano, Marcelo; Teresa Pereira, Ma; Ortigueira, Juan M.; Gayoso, Eduardo; Lopez-Torres, Margarita; Vila, Jose M.; Journal of Organometallic Chemistry; vol. 740; (2013); p. 92 – 97;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6163-58-2, Tri-o-tolylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6163-58-2, (2R)-(4E)-5-(5-Isopropoxy-3-pyridyl)-4-penten-2-ol A mixture of 5-bromo-3-isopropoxypyridine (10.26 g, 47.50 mmol), (2R)-4-penten-2-ol (4.91 g, 57.00 mmol), palladium(II) acetate (106 mg, 0.47 mmol), tri-o-tolylphosphine (578 mg, 1.90 mmol), triethylamine (28.46 mL, 204.25 mmol), and acetonitrile (30 mL) were heated in a sealed glass tube at 140 C. for 14 h. The reaction mixture was cooled to ambient temperature, diluted with water, and extracted with chloroform (3*200 mL). The combined chloroform extracts were dried over sodium sulfate, filtered, and concentrated by rotary evaporation to give a pale-yellow oil (8.92 g, 85.0%).

The synthetic route of 6163-58-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Targacept, Inc.; US6218383; (2001); B1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.166330-10-5,(Oxybis(2,1-phenylene))bis(diphenylphosphine),as a common compound, the synthetic route is as follows.

General procedure: A solution of [Cu(CH3CN)4](ClO4) (35.3mg, 0.108mmol) and 1,2-bis(diphenylphosphino)ethane (dppe) (43.2mg, 0.108mmol) in CH2Cl2 (10mL) was stirred for 30min at room temperature. A solution of Hbmp (22.6mg, 0.108mmol) in CH2Cl2 (5mL) was added, and this mixture was stirred for another 2h to give a light-yellow solution. The solvent was evaporated to dryness at reduced pressure. The residue was dissolved in a mixture of acetone/dichloromethane (1:5 v/v), and slow diffusion of petroleum ether into the above solution gave light-yellow crystals of 2 (69.4mg, 0.090mmol, 83percent)., 166330-10-5

The synthetic route of 166330-10-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Di, Bao-Sheng; Chen, Jing-Lin; Luo, Yan-Sheng; Zeng, Xue-Hua; Qiu, Lu; He, Li-Hua; Liu, Sui-Jun; Wen, He-Rui; Polyhedron; vol. 119; (2016); p. 525 – 531;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate