Day: October 16, 2020

50777-76-9, 2-(Diphenylphosphino)benzaldehyde is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

50777-76-9, General procedure: To a dichloromethane solution (15 mL) of 2-diphenylphosphinobenzaldehyde (ca. 3 mmol) was added an equimolar amount of the appropriate substituted amine. An excess of magnesium sulphate was also added to the reaction mixture to remove the water by-product. The reaction was left to stir at room temperature for 16 h, after which time the magnesium sulphate was filtered off and the solvent removed from the filtrate in vacuo to give a yellowe orange oil. The oily crude products of ligands 1a-1f were solidified by dissolving the oil in hot hexane, followed by quick hot filtration of the liquid product. The resultant solution was then cooled at -16 ¡ãC overnight to give an off-white powder, which was filtered and dried in vacuo.

The synthetic route of 50777-76-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Mogorosi, Mokgolela M.; Mahamo, Tebello; Moss, John R.; Mapolie, Selwyn F.; Slootweg, J. Chris; Lammertsma, Koop; Smith, Gregory S.; Journal of Organometallic Chemistry; vol. 696; 23; (2011); p. 3585 – 3592;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.855-38-9,Tris(4-methoxyphenyl)phosphine,as a common compound, the synthetic route is as follows.,855-38-9

Example 3 Synthesis of TMPO The following is an exemplary procedure for the synthesis of tris(4-methoxyphenyl)phosphine oxide (TMPO, VI) as depicted in . Into a 100 mL three-necked flask equipped with a magnetic stir bar and nitrogen inlet and outlet were placed tris(4-methoxyphenyl)phosphine (TMP, V) (3.0 g, 8.5 mmol) and acetone (30 mL). A mixture of water (2 mL) and H2O2 (35%, 1 mL, 9 mmol) was added slowly. After the mixture had been stirred at room temperature for 1 hour, the acetone was evaporated, and methylene chloride (50 mL) was added. The organic phase was washed with a saturated NaCl solution (35 mL) three times with the aid of a separatory funnel. The organic layer was then dried over anhydrous sodium sulfate. Finally, the solvent was removed via rotary evaporation to afford 3.0 g (95%) of a white solid, m.p. 144.7-145.4 C. MS (m/e): 368 (M+). Anal. Calcd. for C21H21O4P: C, 68.47%; H, 5.75%; P, 8.41%. Found: C, 68.42%; H, 5.72%; P, 8.11%. FT-IR (KBr, cm-1): 3068, 3026, 2959, 2837, 1597, 1569, 1503, 1468, 1289, 1254, 1179, 1121, 1019, 803, 671, 543. 1H-NMR (CDCl3, delta in ppm): 3.84 (s, 6H, CH3), 6.94-6.97 (dd, 6H, Ar-H), 7.54-7.60 (dd, 6H, Ar-H). 13C-NMR (DMSO-d6, delta in ppm): 55.29, 114.08, 114.21, 124.19, 125.28, 133.21, 133.32, 161.79, 161.82.

855-38-9 Tris(4-methoxyphenyl)phosphine 70071, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; The United States of America as represented by the Secretary of The Air Force; Tan, Loon-Seng; Wang, David Huabin; US8546614; (2013); B1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6372-42-5, Cyclohexyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,6372-42-5

Solid silver thiocyanate (0.0604 g, 0.36 mmol) was added to the solution of cyclohexyldiphenylphosphine(0.1922 g, 0.72 mmol) in ethanol (40 mL) and DMSO (30 mL). The reaction mixturewas placed under reux for 5.5 h followed by ltration. The ethanol was removed byevaporation. The ltrate was placed in the freezer which resulted in the solution freezing andupon melting small white crystals were isolated (0.0751 g, 30%), m.p. 190-193 C. Anal. Calcdfor C37H42Ag1N1S1P2: C, 63.25; H, 6.03; N, 1.99; S, 4.56%. Found: C, 62.91; H, 5.99; N, 1.74%. SolidFTIR (nu, in cm-1): 3050(w) nu(=C-H); 2929, 2845(m) nu(C-H); 2069(m) nu(SCN); 1480, 1432(m) nu(C=C);1328 (w); 1174 (w); 1095(w) nu(P-C); 1025, 998(s) deltaasym (C-H); 915, 886, 848, 733, 692(m) delta(C-H).1H NMR (400 MHz, CDCl3) (delta, in ppm): 1.19 (m, 10H, cyclohexyl); 1.62 (m, 12H, cyclohexyl); 2.40(d, 3J(H-H) = 9.2 Hz, cyclohexyl); 7.30 (t, 3 J(H-H) = 7.2 Hz, H-aromatic); 7.36 (t, 3J(H-H) = 7.2 Hz,H-aromatic); 7.49 (t, 3J(H-H) = 8.6 Hz, H-aromatic). 13C{H} NMR (100 MHz, CDCl3) (delta, in ppm):25.72 (para C); 26.69 (d, 2J(P-C) = 9.7 Hz, cyclohexyl, C2); 29.16 (d, 3J(P-C) = 6.0 Hz, cyclohexyl,C3); 35.60 (d, 1J(P-C) = 11.2 Hz, cyclohexyl, C1); 128.80 (d, 3J(P-C) = 9.0 Hz, meta C, phenyl);130.17 (s, para C, phenyl); 131.23 (d, 1J(P-C) = 23.0 Hz, ipso C, phenyl); 133.69 (d, 2J(P-C) = 15.0 Hz, ortho C, phenyl). 31P{H} NMR (161 MHz, CDCl3) (delta, in ppm): 16.25.

As the paragraph descriping shows that 6372-42-5 is playing an increasingly important role.

Reference£º
Article; Potgieter, Kariska; Engelbrecht, Zelinda; Naganagowda, Gadada; Cronje, Marianne J.; Meijboom, Reinout; Journal of Coordination Chemistry; vol. 70; 15; (2017); p. 2644 – 2658;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1608-26-0,N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine,as a common compound, the synthetic route is as follows.

Under nitrogen protection, Weigh 2g of compound 5 in a 50mL dry two-necked bottle, Add 15 mL of dry toluene, Slowly add 0.7 mL of tris(dimethylamino)phosphine, Reflux for 4 h. The solvent was removed under reduced pressure. The crude product is separated by a column, I got 1.96g of compound J, Yield 86%, 1608-26-0

The synthetic route of 1608-26-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Shanghai Jiao Tong University; Cui Yong; Chen Xu; Liu Yan; (21 pag.)CN108586529; (2018); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13991-08-7,1,2-Bis(diphenylphosphino)benzene,as a common compound, the synthetic route is as follows.

General procedure: A mixture of CuCl (19.6mg, 0.2mmol) and dppb (89.3mg, 0.2mmol) with an excess of batho (66.5mg, 0.2mmol) were dissolved in CH2Cl2 (5mL) and 17 CH3OH (5mL) solution, stirred at room temperature for 6h. The insoluble residues were removed by filtration, and the filtrate was evaporated slowly at room temperature to yield yellow crystalline products., 13991-08-7

13991-08-7 1,2-Bis(diphenylphosphino)benzene 498379, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Yu, Xiao; Fan, Weiwei; Wang, Guo; Lin, Sen; Li, Zhongfeng; Liu, Min; Yang, Yuping; Xin, Xiulan; Jin, Qionghua; Polyhedron; vol. 157; (2019); p. 301 – 309;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13991-08-7, 1,2-Bis(diphenylphosphino)benzene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Under argon atmosphere, 25 mL of dry acetonitrile was added to silver(I) chloride (150 mg, 1.04 mmol) and 1,2-bis(diphenylphosphino)benzene (467 mg, 1.04 mmol), and the mixture was stirred at room temperature for one hour, followed by reflux for five hours. The reaction solution was allowed to reach room temperature, concentrated, and filtrated after being suspended in 7 mL of chloroform. The filtrated matter was subjected to thermal recrystallization from acetonitrile-chloroform and dried to obtain 258 mg of the colorless crystal complex. Under argon atmosphere, 3 mL of dry dichloromethane was added to the above obtained complex (80.0 mg, 0.0678 mmol) and triphenylphosphine (35.6 mg, 0.136 mmol), and the mixture was stirred at 40C for 10 minutes. The reaction solution was concentrated, subjected to recrystallization by slow diffusion of chloroform-ether, and dried to provide 107 mg of the colorless crystal complex. The result of elemental analysis for the obtained complex is shown in Table 2-2, and the composition ratio of the complex was obtained. The present complex corresponds to the above composition formula (3). [Show Image] The NMR data of the obtained complex is provided below. 1H NMR (300 MHz, CDCl3) delta 7.48-7.17 (m, 31H), 7.06 (t, J = 7.0 Hz, 8H); 13C NMR (75 MHz, CDCl3) delta 134.9-134.8 (m), 134.5 (br), 134.4-134.1 (m), 130.1 (br), 129.7 (br), 129.8-129.7 (m), 129.0 (br), 128.9 (br), 128.8-128.7 (m); 31P NMR (122 MHz, CDCl3) delta 9.1 (br, W1/2 = 66 Hz), -14.8 (br, W1/2 = 390 Hz). The result of DART-MS measurement for the obtained complex is provided below. DART-MS (M/Z): found; 815.16. calcd; 815.13 (M-C1)+. Based on the DART-MS measurement of the obtained complex, it was confirmed that the obtained complex contained the following structure.

13991-08-7, 13991-08-7 1,2-Bis(diphenylphosphino)benzene 498379, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Sumitomo Chemical Company, Limited; EP2360162; (2011); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1608-26-0,N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine,as a common compound, the synthetic route is as follows.

General procedure: A mixture of the aminobenzamidine 1 (5.0 mmol) andtris (dimthylamino) phosphine (5.0 mmol) dissolved in anhydroustoluene (10 mL) were heated under reflux for 48 h.After evaporating the solvent in vacuum, the resulting solidproduct was recrystallized from CCl4 (2b, 2d) or alternativelythe obtained oil (2a, 2c) was purified by columnchromatography using silica gel (60-120 mesh) with ethylacetate: petroleum ether (4 : 6) as eluant.2a: N,N-dimethyl-4-(propylimino)-3,4-dihydro-1,3,2-benzodiaza-phosphorin-2(1H)-amineYield : 70%, brown viscous oil. IR (FTIR, nu (cm-1)): nu(C=N) = 1634; nu (NH) = 3319. 1H NMR (CDCl3+DMSO-d6,delta (ppm)): delta = 0.80 (t, 3H, 3JH-H = 6 Hz, CH3-CH2); 1.20 (m,2H, 3JH-H = 6.3 Hz, CH3-CH2); 2.45 (d, 3JHP = 6 Hz, N-CH3);2.47 (d, 3JHP = 6 Hz, N-CH3); 2.90 (t, 2H, 3JH-H = 6.3 Hz, NCH2);5.20(broad s, 2H, NH); 6.50-7.70(m, 4H, Harom). 13CNMR (CDCl3+DMSO-d6, delta (ppm)): 14.90 (CH3-CH2); 29.0(CH3-CH2); 34.10 (C=N-CH2); 34.25 (N-CH3); 36.26 (NCH3);114.90; 122.20; 128.90; 130.50; 132.90; (Carom);133.51 (Carom-N-P); 153.86 (P-N-C=N-CH2). 31P NMR(CDCl3+ DMSO-d6, delta (ppm)): 0.29. Calcd. C12H19N4P : %C= 57.60 % H = 7.60 % N = 22.40; Found: %C = 57.59 % H= 7.65 % N = 22.39., 1608-26-0

The synthetic route of 1608-26-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Hichri, Sarra; Abderrahim, Raoudha; Letters in Organic Chemistry; vol. 13; 4; (2016); p. 289 – 292;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13991-08-7,1,2-Bis(diphenylphosphino)benzene,as a common compound, the synthetic route is as follows.

Under argon atmosphere, silver(I) iodide (235 mg, 1.00 mmol) and 50 mL of the solution of 1,2-bis(diphenylphosphino)benzene (447 mg, 1.00 mmol) in acetonitrile were mixed and the mixture was heated to reflux with stirring for seven hours. The reaction solution was allowed to reach room temperature and the precipitated colorless crystal was filtrated. The obtained filtrated matter was washed with acetonitrile and dried to obtain 531 mg of the complex. The mixture of this complex (49.7 mg) and triphenylphosphine (19.2 mg, 0.0730 mmol) was dissolved in 3 mL of dichloromethane, and the resulting solution was stirred for 30 minutes at room temperature. The reaction solution was concentrated, subjected to recrystallization by slow diffusion of chloroform-diethylether, and dried to provide 30.9 mg of the colorless solid complex. The result of elemental analysis for the obtained complex is shown in Table 2-1, and the composition ratio of the complex was obtained. The present complex corresponds to the above composition formula (3). [Show Image] The NMR data of the obtained complex is provided below. 1H NMR (300 MHz, CDCl3) delta 7.44-7.14 (m, 31H), 7.03 (t, J= 7.2 Hz, 8H); 13C NMR (75 MHz, CDCl3) delta 141.2 (t, J= 22.7 Hz), 134.5 (t, J= 3.0 Hz), 134.2-134.0 (m), 133.3 (d, J= 22.2 Hz), 132.2 (t, J= 10.9 Hz), 129.6 (s), 129.3 (s), 128.5 (d, J= 9.0 Hz), 128.2 (t, J= 4.5 Hz); 31P NMR (122 MHz, CDCl3) delta 3.7 (br, W1/2=159 Hz), -14.8 (br, W1/2 = 450 Hz). The result of DART-MS measurement of the obtained complex is provided below. DART-MS (M/Z): found; 815.16. calcd; 815.13 (M-I)+. Based on the DART-MS measurement of the obtained complex, it was confirmed that the obtained complex contained the following structure.

13991-08-7, As the paragraph descriping shows that 13991-08-7 is playing an increasingly important role.

Reference£º
Patent; Sumitomo Chemical Company, Limited; EP2360162; (2011); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

12150-46-8, 1,1-Bis(diphenylphosphino)ferrocene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Complex 1 (0.112 g, 0.20 mmol) was dissolved in dryMeCN (20 ml) under argon, and Me3NO2H2O (0.022 g,0.20 mmol) was added. The color of the solution changed from red to brown immediately. After stirring at room temperature for 0.5 h, the resulting solution was mixedwith dppf (0.056 g, 0.10 mmol) and stirred for 3 h at the room temperature. The solvent was removed on a rotary evaporator, and the residue was subjected to preparativeTLC separation using CH2Cl2/petroleum ether (v/v = 1:1)as the eluent. From the main red band, complex 3 wasobtained as a red solid (0.072 g, 81 percent). IR (KBr disk cm-1): mC:O 2036 (vs), 1973 (vs), 1922 (m). 1H NMR(400 MHz, CDCl3, ppm): 1.67 (s, 6 H, 2 CH, 4 SCHaHe),2.22 (s, 4 H, 4 SCHaHe), 4.22 (s, 4 H, C5H4), 4.46 (s, 4 H,C5H4), 6.35 (s, 4 H, C6H5), 7.12 (s, 6 H, C6H5), 7.35 (m, 12H, C6H5), 7.59 (s, 8 H, C6H5). 31P NMR (161.9 MHz,CDCl3, 85 percent H3PO4, ppm): 55.1 (s). Anal. Calc. for C68-H62Fe5O10P2Se4: C, 48.2; H, 3.7. Found: C, 48.4; H, 3.4 percent.

12150-46-8, 12150-46-8 1,1-Bis(diphenylphosphino)ferrocene 51341936, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Li, Chang-Gong; Cui, Mao-Jin; Xue, Feng; Zhu, Yong; Li, Yong-Fang; Shang, Jing-Yan; Niu, Hong-Ying; Transition Metal Chemistry; vol. 40; 5; (2015); p. 493 – 500;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

7650-91-1,7650-91-1, Benzyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Weigh benzyl diphenylphosphine (138.2 g, 0.5 mol), dimethyl carbonate (135.1 g, 1.5 mol),Benzene (68.3 g, 25%) and 80%-Cs2O/SiO2 catalyst (1.37 g, 0.5%) were added to a stainless steel autoclave,The air in the reaction vessel was replaced by N2, and the temperature was raised to 160 C for 8 hours.After completion of the reaction, the cooling water was cooled to 65 C, and the catalyst was recovered by filtration, and the unreacted raw materials and solvent were distilled off under reduced pressure.The product was washed with n-hexane and then dried under vacuum at 60 C for 5 hours to give benzyldiphenylmethylmethyl carbonate (164.9 g) in a yield of about 90%.The methyl carbonate quaternary phosphonium salt benzyl diphenyl methyl carbonate hydrazine (55.0 g, 0.15 mol) was weighed and dissolved in dichloromethane (137.5 g).Trifluoromethanesulfonic acid (22.5 g, 0.15 mol) was added, and the mixture was refluxed under magnetic stirring at 50 C for 3 hours.After completion of the reaction, the solvent was removed by distillation under reduced pressure to give 62.8 g of benzyldiphenylmethyltrifluoromethanesulfonate ionic liquid, yield of about 95%.

7650-91-1 Benzyldiphenylphosphine 603920, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; China Daily Expenses Chemical Institute Co., Ltd.; Geng Tao; Duan Shengfu; Jiang Yajie; Ju Hongbin; Wang Yakui; (8 pag.)CN108440595; (2018); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate